Polymorphisms in the CTLA-4 Gene and Rheumatoid Arthritis Susceptibility: A Meta-analysis

Li, Xiaobo; Zhang, Cong; Zhang, Jie; Zhang, Yonggang; Wu, Zhangjun; Yang, Liang; Xiang, Zhangpeng; Zhan-zhong, QI; Zhang, Xin; Xiao, Xingqiong

doi:10.1007/s10875-012-9650-y

Cited by 29 publications

(20 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the subgroup analysis by ethnicity, results suggested that strong evidences support the association between RA risk and CTLA-4 A49G polymorphism in both Asian and Caucasian populations. Previous meta-analyses works have reported that the CTLA-4 A49G polymorphism is associated with RA risk in Asians, but not in Caucasians using limited data [37,38]. In our work, we performed an up-dated meta-analyses, and found that A49G polymorphism is associated with RA risk in both Asians and Caucasians.…”

Section: Discussionmentioning

confidence: 52%

The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis

Shi

Liu

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

BackgroundRecently, a number of studies have been performed to explore the association between CTLA-4 A49G polymorphism and rheumatoid arthritis (RA). However, the results of previous works are still controversial and ambiguous.MethodsIn this work, we attempted to perform an updated meta-analysis of available case–control study in order to assess the association between CTLA-4 A49G polymorphism and RA risk. We searched the various citation databases without limits on languages. Article searching was performed by screening the references of retrieved studies manually. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of the association.ResultsWe totally compiled 27 studies in 24 articles (9805 RA patients and 10691 control subjects) into our meta-analysis work. We found significant association between CTL-A4 A49G polymorphism and RA risk (GG vs. AA: OR = 1.13, 95% CI = 1.03–1.23; GA vs. AA: OR = 1.19, 95% CI = 1.07–1.33; GA + GG vs. AA: OR = 1.18, 95% CI = 1.07–1.29). In the subgroup analysis by ethnicity, evidences of significantly increased risk was also found in both Asian (GG vs. AA: OR = 1.34, 95% CI = 1.15–1.55; GA + GG vs. AA: OR = 1.24, 95% CI = 1.08–1.41) and Caucasian population (GA vs. AA: OR = 1.19, 95% CI = 1.03–1.37; GA + GG vs. AA: OR = 1.14, 95% CI = 1.01–1.29). No evidence of publication bias was found in this work.ConclusionsOur meta-analysis suggests that CTLA-4 A49G polymorphism was associated with RA risk.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_157

show abstract

Section: Discussionmentioning

confidence: 52%

The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis

Shi

Liu

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

show abstract

“…Besides, a genetic study has also indicated that there is an association of CTLA-4 gene polymorphism with susceptibility to RA [24]. All these work suggest that co-stimulatory molecule CTLA-4 plays a central role in RA.…”

Section: Discussionmentioning

confidence: 90%

Increased production of circulating soluble co-stimulatory molecules CTLA-4, CD28 and CD80 in patients with rheumatoid arthritis

Cao

Zou

luo

et al. 2012

International Immunopharmacology

View full text Add to dashboard Cite

“…The function of gene can be influenced by number of genetic variations, including single nucleotide polymorphisms (SNPs), and resulting in disease phenotypes. Indeed, as evidenced in our previous study and in numerous others, several CTLA-4 polymorphisms that may influence gene expression, lead to amino acid substitution, and alter mRNA splicing have been linked with susceptibility to autoimmune diseases, including autoimmune thyroid diseases, systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes [9–15]. Thus, it is hypothesized that in cancer disease antitumor responses such as proliferation and activation of tumor-specific CTLs may also be altered by genetic polymorphisms in CTLA-4 gene.…”

Section: Introductionmentioning

confidence: 86%

CTLA-4 Expression and Polymorphisms in Lung Tissue of Patients with Diagnosed Non-Small-Cell Lung Cancer

Antczak

Pastuszak-Lewandoska

Górski

et al. 2013

BioMed Research International

View full text Add to dashboard Cite

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a potent immunoregulatory molecule that downregulates T-cell activation and thus influences the antitumor immune response. CTLA-4 polymorphisms are associated with various cancers, and CTLA-4 mRNA/protein increased expression is found in several tumor types. However, most of the studies are based on peripheral blood mononuclear cells, and much less is known about the relationship between CTLA-4 expression, especially gene expression, and its polymorphic variants in cancer tissue. In our study we assessed the distribution of CTLA-4 two polymorphisms (+49A/G and −318C/T), using TaqMan probes (rs231775 and rs5742909, resp.), and CTLA-4 gene expression in real-time PCR assay in non-small-cell lung cancer (NSCLC) tissue samples. The increased CTLA-4 expression was observed in the majority of NSCLC patients, and it was significantly correlated with TT genotype (−318C/T) and with tumor size (T2 versus T3 + T4). The presence of G allele and GG genotype in cancer tissue (+49A/G) was significantly associated with the increased NSCLC risk. Additionally, we compared genotype distributions in the corresponding tumor and blood samples and found statistically significant differences. The shift from one genotype in the blood to another in the tumor may confirm the complexity of gene functionality in cancer tissue.

show abstract

Polymorphisms in the CTLA-4 Gene and Rheumatoid Arthritis Susceptibility: A Meta-analysis

Abstract: This meta-analysis suggested that the +49A/G and CT60 polymorphisms in the CTLA-4 gene may be risk factors for RA.

Cited by 29 publications

References 30 publications

The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis

The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk: a meta-analysis

Increased production of circulating soluble co-stimulatory molecules CTLA-4, CD28 and CD80 in patients with rheumatoid arthritis

CTLA-4 Expression and Polymorphisms in Lung Tissue of Patients with Diagnosed Non-Small-Cell Lung Cancer

Contact Info

Product

Resources

About