The Fbxw7/hCdc4 tumor suppressor in human cancer

Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid

“…The E3 ubiquitin ligase Fbxw7 is involved in the ubiquitination and degradation of the NICD (Tan et al, 2008; of the sEH in the cells used (Barbosa-Sicard et al, 2009) and its conversion to 19,20-DHDP.…”

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun

“…3). In contrast, the cellularity in compartments harbouring immature cells was either unaffected, as in the cortical ventricular zone (VZ), or increased, as seen in 5 the tectal VZ ( Fig. 1a-d).…”

“…SCF(Fbw7) targets several important oncoproteins, including c-Myc, c-Jun, CyclinE1 and Notch, for ubiquitin-dependent proteolysis and Fbw7 mutations have been detected in a variety of human cancers, indicating that Fbw7 is a tumour suppressor [4][5][6] .…”

Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen

“…The loss and mutation of this gene is frequently detected in various types of cancers (Mao et al, 2004;Perez-Losada et al, 2005;Tan et al, 2008;Crusio et al, 2010). To address whether downregulation of Fbxw7 mimicked the effects from increase of miR-27a expression, we introduced specific siRNAs duplex targeting Fbxw7 into HBER cells.…”