2010
DOI: 10.1194/jlr.m000588
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The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues

Abstract: This article is available online at http://www.jlr.org derived from the biosynthetic pathways resulting in the conversion of essential precursors to their respective elongated polyenoic products.The availability of PUFA in mammalian cells greatly depends on the activity of enzymes involved in FA metabolism. In animals and humans, the ⌬ 5-and ⌬ 6-desaturases are the pivotal enzymes introducing de novo unsaturations in the carbon chain of precursors leading to the synthesis of long-chain PUFA (LC-PUFA). These en… Show more

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Cited by 40 publications
(47 citation statements)
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“…2), which encode for D5-and D6-fatty acid desaturase activities (involved in polyunsaturated fatty acid biosynthesis), respectively, and FADS3, whose function has not been established yet (Pedrono et al 2010). Although the mRNA levels for FADS1 and FADS2 were not detected under our experimental conditions, we observed a relative decrease in Fig.…”
Section: Diet and Fatty Acid Desaturation In Adipose Tissuementioning
confidence: 52%
“…2), which encode for D5-and D6-fatty acid desaturase activities (involved in polyunsaturated fatty acid biosynthesis), respectively, and FADS3, whose function has not been established yet (Pedrono et al 2010). Although the mRNA levels for FADS1 and FADS2 were not detected under our experimental conditions, we observed a relative decrease in Fig.…”
Section: Diet and Fatty Acid Desaturation In Adipose Tissuementioning
confidence: 52%
“…FADS3 mRNA was shown to be ubiquitously expressed in a large variety of tissues in humans ( 7 ), baboons ( 12 ), and rats ( 11 ), with a specifi c distribution compared with FADS1 and FADS2 mRNAs. In neonate baboon tissues, seven alternative transcripts of FADS3 were described ( 12 ), but when they were cloned and expressed into yeast and mammalian cells, no activity toward a variety of PUFA substrates was detected ( 16 ).…”
Section: Fatty Acid Analysismentioning
confidence: 99%
“…The plasmids constructed for expressing rat FADS2 (pCMV/ FADS2) and FADS3 (pCMV/FADS3) in mammalian cells have been described ( 11,24 ). A plasmid coding for rat FADS1 was also constructed.…”
Section: Plasmid Constructs For Expressing Rat Fads1 Fads2 and Fadsmentioning
confidence: 99%
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