The fate of the tumour in infantile hypertrophic pyloric stenosis

Armitage, George; Rhind, J. A.

doi:10.1002/bjs.18003915308

Cited by 17 publications

(3 citation statements)

References 9 publications

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“…On the other hand, bypassing the obstruction may result in persistence of the hypertrophied muscle for many years (36). Thus, it is difficult to postulate that the undeniable abnormalities of the muscular layer are congenital, given their rapid resolution after relief of obstruction and the absence of functional or anatomic abnormalities at birth.…”

Section: Etiologic Considerationsmentioning

confidence: 98%

Infantile Hypertrophic Pyloric Stenosis

2003

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Infantile hypertrophic pyloric stenosis is a common condition affecting young infants; despite its frequency, it has been recognized only for a little over a century, and its etiology remains unknown. Nevertheless, understanding of the condition and of effective treatment have undergone a remarkable evolution in the 20th century, reducing the mortality rate from over 50% to nearly 0%. The lesion is characterized by gastric outlet obstruction and multiple anatomic abnormalities of the pyloric antrum. The antropyloric muscle is abnormally thickened and innervated, and the intervening lumen is obstructed by crowded and redundant mucosa. Recognition of the obstructive role of the mucosa led to discovery of effective surgical treatment. Accurate clinical diagnosis in patients in whom a thickened antropyloric muscle is not readily palpable can be difficult, resulting in delayed diagnosis and can lead to emaciation and electrolyte imbalance, making the patient a suboptimal surgical candidate. Current imaging techniques, particularly sonography, are noninvasive and accurate for identification of infantile hypertrophic pyloric stenosis. Successful imaging requires understanding of anatomic changes that occur in patients with this condition and plays an integral role in patient care. Accurate, rapid, noninvasive imaging techniques facilitate rapid referral of vomiting infants and prompt surgical treatment of more suitable surgical candidates.

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Section: Etiologic Considerationsmentioning

confidence: 98%

Infantile Hypertrophic Pyloric Stenosis

2003

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“…It has been clearly shown that congenital pyloric hypertrophy can persist into adult life, unless treated by pyloromyotomy (Rammstedt, 1912;Holt, 1917;Armitage and Rhind, 1951;Lumsden and Truelove, 1958). Runstrom (1939) studied 107 children with congenital pyloric stenosis treated medically and showed that the radiological abnormalities became less frequent with advancing years, but were still present long after there were no symptoms.…”

Section: Aetiologymentioning

confidence: 99%

Simple and complicated hypertrophic pyloric stenosis in the adult

Wm¹

1965

Gut

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“…If the infant is treated by gastro-jejunostomy the tumour frequently remains unaltered (Holt, 1917), even well into adult life (Donovan, 1946;Walters, 1946;Armitage and Rhind, 1951 ;and others). Indeed, the cases recorded suggest that the tumour nearly always does persist after gastrojejunostomy, though this may be an erroneous impression, as the absence of a tumour at a subsequent operation may be overlooked or not regarded as worthy of record.…”

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confidence: 99%