The Fate and Effects of Transfused Serum or Plasma in Normal Dogs

Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation. Xxxiv. Comparative Studies on the Nutritive Value of Orally and Intravenously Administered Human Serum Albumin in Man 123

“…Parenterally injected albumin and plasma proteins disappear rapidly from the blood stream (1,21), but repeated injections are followed by an appreciable and readily detectable increase in the total circulating plasma proteins, as reported here and by others (5,10,12). It is clear that roughly 24 to 46 per cent of the protein retained in our subjects could be accounted for by the albumin increase in the blood plasma (Table II, hydrolysate).…”

The Effects of an Increase in Plasma Volume on the Metabolism and Excretion of Water and Electrolytes by Normal Subjects 12

“…Knowlton (1) and Podhradszky (14) reported a diminished rate of flow of urine with infusions of solutions of colloid in contrast to saline in rabbits and dogs. However, Metcalf (15) and Orloff and Blake (16) reported an increase in the rate of excretion of water in dogs in response to infusions of plasma and concentrated human serum albumin.…”

Chemical, Clinical, and Immunological Studies on the Products of Human Plasma Fractionation Xxx. The Use of Salt-Poor Concentrated Human Serum Albumin Solution in the Treatment of Chronic Bright's Disease 123

“…Following a suggestion by Peters(35), evidence was presented for a correlation between diuresis and increase in plasma volume rather than an increase in colloid osmotic pressure (36,2). Although the possibility of this mechanism found corroboration in studies of urine output following plasma infusion into normal dogs (37), increases in blood volume were observed in nephrotics, following plasma therapy where no diuresis occurred (3). Again, whereas an increased chloride output has been described (34), the chloride loss during diuresis following acacia infusion was roughly equal to the amount of chloride in the injected acacia solution plus that of the excreted edema fluid (38).…”