The familial occurrence of intracranial aneurysms

Background and Purpose-We sought to examine the relation between a family history of subarachnoid hemorrhage (SAH) and the risk of SAH by using a case-control study. Methods-Case subjects consisted of a consecutive series of 195 patients with spontaneous SAH, aged 30 to79 years, with aneurysms confirmed by angiography and/or CT scan. Hospital and community control subjects were identified and matched to each case by sex and age (Ϯ2 years). Multiple conditional logistic regression was used to calculate the odds ratio (OR) and 95% interval (CI) adjusted for potential confounders. Results-Having a family member with SAH was significantly associated with an increased risk of SAH (OR, 4.0, 95% CI, 2.0 to 8.0), after adjusting for potential confounders. The risk for a positive family history of SAH was similar for men and women and was inversely related to the SAH patient's age. A maternal positive SAH history (OR, 5.4; 95% CI, 1.8 to 16.0) posed a much greater risk than a paternal positive history (OR, 3.2, 95% CI, 1.1 to 13.4). Conclusions-A positive family history of SAH was significantly and strongly associated with the risk of SAH. To prevent the onset of SAH at a younger age, much more attention should be given to individuals with any family member (first-degree relatives) suffering SAH episodes.

Section: Discussionsupporting

confidence: 53%

Family History and Risk of Subarachnoid Hemorrhage

Okamoto

Horisawa

Kawamura

et al. 2003

“…[3][4][5][6][7][8] One study investigated the association of single nucleotide polymorphisms on 9p21 with IA location and found that posterior communicating artery and posterior circulation IAs had stronger associations than the anterior circulation group. 11 Recent genomewide association studies have identified loci associated with IA, 12-14 but these studies did not stratify by IA location, and this is an unexplored avenue of investigation.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Previous reports noted family members with IAs in similar locations and twins with IAs in identical locations. [3][4][5][6][7][8] These data suggest that there may be heritable susceptibility to IA location. We tested the hypothesis that anatomic susceptibility to IA location exists using a large multicenter family-based IA study.…”

mentioning

confidence: 82%

Familial Intracranial Aneurysms

Mackey

Brown

Moomaw

et al. 2013

The Familial Intracranial Aneurysm (FIA) Study is a multicenter international study with 41 recruitment sites in North America, Australia, and New Zealand. The detailed methodology of the FIA Study has been published previously. 9 The overall goal of the study is to identify genetic and other risk factors for the formation and rupture of IAs. The FIA study was approved by the Institutional Review Boards/Ethics Committees of all recruitment and analytic sites.Background and Purpose-Previous studies have suggested that family members with intracranial aneurysms (IAs) often harbor IAs in similar anatomic locations. IA location is important because of its association with rupture. We tested the hypothesis that anatomic susceptibility to IA location exists using a family-based IA study. Methods-We identified all affected probands and first-degree relatives (FDRs) with a definite or probable phenotype in each family. We stratified each IA of the probands by major arterial territory and calculated each family's proband-FDR territory concordance and overall contribution to the concordance analysis. We then matched each family unit to an unrelated family unit selected randomly with replacement and performed 1001 simulations. The median concordance proportions, odds ratios (ORs), and P values from the 1001 logistic regression analyses were used to represent the final results of the analysis.

“…44 This figure is in accordance with the widely accepted statistic for the prevalence of intracranial aneurysms in the general population of 2%, which is derived from a review of 8 autopsy series. 45 In our NF1 autopsy series, the prevalence of intracranial aneurysms was 0 of 25 patients. The prevalence of 0 of 25 patients is not statistically different from the 1.3% prevalence of intracranial aneurysms in the autopsy population at this institution (Pϭ0.72) or from the 2.0% prevalence of intracranial aneurysms in the general population (Pϭ0.60).…”

Section: Discussionmentioning

confidence: 72%

“…45 Statistical comparisons were made by using the binomial probability test (Stata Statistical Software, version 6.0, Stata Corp).…”

Section: Discussionmentioning

confidence: 99%

Lack of Evidence for an Association Between Neurofibromatosis Type I and Intracranial Aneurysms: Autopsy Study and Review of the Literature

Conway¹,

Hutchins²,

Tamargo³

2001

Background and Purpose-Neurofibromatosis type I (NF1) is an autosomal dominant, hereditary, neurocutaneous syndrome purported to be associated with intracranial aneurysms. To study the relationship between NF1 and intracranial aneurysms, we have analyzed all intracranial autopsies of NF1 patients performed at our institution from 1889 to 1999 and analyzed all intracranial aneurysm cases at our institution from 1990 to 1999 in an attempt to identify patients with NF1. In addition, we have reviewed published clinical series of NF1 patients. Methods-The autopsy database at our institution, which contains 50 000 cases from 1889 to 1999, was searched to identify NF1 patients, and the results of these autopsies were reviewed. The prevalence of intracranial aneurysms in these NF1 patients was compared with the prevalence of intracranial aneurysms in our hospital's autopsy population and with the published prevalence of intracranial aneurysms in the general population. To identify patients with intracranial aneurysms and NF1, our institution's intracranial aneurysm database was searched for patients with clinical manifestations of NF1. Published clinical series of NF1 patients were identified through searches of the literature. Results-None of the 25 autopsy patients with NF1 had an intracranial aneurysm. None of the 925 patients treated for intracranial aneurysms were affected by NF1. A review of the literature identified 8 comprehensive clinical studies, all of which failed to document any relationship between NF1 and intracranial aneurysms. Conclusions-The autopsy prevalence of no NF1 patients with intracranial aneurysms out of 25 is not different from the prevalence of intracranial aneurysms in the general autopsy population. In addition, no patients treated for intracranial aneurysms at this institution had NF1. These findings are supported by the observation that an association between NF1 and intracranial aneurysms has never been identified in 8 large clinical studies of NF1 patients. We conclude that there is a lack of evidence for any association between NF1 and intracranial aneurysms.