Family History and Risk of Subarachnoid Hemorrhage

Okamoto, Kazushi; Horisawa, Rokuro; Kawamura, Takashi; Asai, Akihiko; Ogino, Masataka; Takagi, Takuji; Ohno, Yoshiyuki

doi:10.1161/01.str.0000053851.17964.c6

Cited by 53 publications

(29 citation statements)

References 47 publications

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“…Our methods were described previously in detail (Okamoto et al, 2001(Okamoto et al, , 2003Okamoto and Horisawa, 2006). Briefly, we recruited all consecutive and incident SAH patients admitted at two large medical hospitals located in Nagoya from April 1992 to March 1997.…”

Section: Methodsmentioning

confidence: 99%

Dietary antioxidant intake and risk of an aneurysmal rupture subarachnoid hemorrhage in Japan

Okamoto

Horisawa

2007

Eur J Clin Nutr

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The purpose of this study was to investigate the relationship between dietary antioxidant intake and the risk of subarachnoid hemorrhage (SAH) in a case-control study. An antioxidant intake score was calculated for individual values for each food group (soy products, green yellow-vegetables, fruits, boiled rice and tea) collected by a self-administered food frequency questionnaire. Incident SAH cases (n ¼ 201) were identified and individually matched for age (72 years) and gender to community (n ¼ 201) controls from April 1992 to March 1997. The antioxidant intake score was inversely associated with the risk of SAH, even after adjusting for confounding factors (lowest vs highest score adjusted odds ratio, 0.54; 95% confidence interval, 0.30-0.99). These findings suggest that the development of SAH may be reduced by the frequent intake of various antioxidants in the diet. Prospective studies are needed to confirm the relationship of dietary antioxidants to SAH risk in Japanese men and women.

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Section: Methodsmentioning

confidence: 99%

Dietary antioxidant intake and risk of an aneurysmal rupture subarachnoid hemorrhage in Japan

Okamoto

Horisawa

2007

Eur J Clin Nutr

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“…[3][4][5] Furthermore, several studies suggested an increased occurrence of IA and SAH in first-and second-degree relatives of SAH, with the incidence rate of 6-10%. [6][7][8][9] Several Mendelian disorders, such as autosomal-dominant polycystic kidney disease and Ehlers-Danlos syndrome type IV are associated with an increased risk of IA formation. 10,11 All these evidence fortified the roles of genetic factors in the pathogenesis of IA.…”

Section: Introductionmentioning

confidence: 99%

Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population

et al. 2011

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Genetic factors are known to have an important role in intracranial aneurysm (IA) pathogenesis. The purpose of this study is to identify single-nucleotide polymorphisms (SNPs) that are associated with IA in Japanese population. A total of 2050 IA patients and 1835 controls recruited in Biobank Japan, The University of Tokyo were used in this study. In all, 45 SNPs in 24 genes encoding proteins, which have been considered to be possible risk factors to IA pathogenesis, were genotyped using multiplex PCR-invader assay. Association analysis was evaluated by logistic regression analysis before and after adjustment of age, smoking and hypertension status. This case-control association study revealed a SNP, rs6460071 located on LIMK1 gene (P¼0.00069) to be significantly associated with increased risk of IA. In addition, two SNPs, rs243847 (P¼0.00086) and rs243865 (P¼0.00090), on matrix metallopeptidase 2 (MMP2) gene and one SNP rs1799724 (P¼0.0026) on tumor necrosis factor-a (TNF-a) gene, are marginally associated with IA in male-and female-specific manner, respectively. In conclusion, a large-scale case-control association study was conducted to verify genetic variations associated with IA in Japanese population. This study gave insights on the importance of stratified analysis between genders, and suggested that the underlying mechanism of IA pathogenesis might differ between females and males.

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“…All other variables, including hypertension, are still subject to debates. [1][2][3] The study of hypertension in SAH is problematic as patients, because of Cushing reflex, frequently show elevated blood pressure, irrespective of being or not hypertensive. 4 The aim of this study was to determine whether confirmed hypertension, prospectively diagnosed with target organ damage criteria, is an independent risk factor for SAH.…”

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confidence: 99%

Risk of Aneurysmal Subarachnoid Hemorrhage

Jiménez-Yepes

Londoño-Fernández

2008

Stroke

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Background and Purpose-From the studied variables in subarachnoid hemorrhage (SAH) risk, hypertension is probably the most controvertible one. The aim of this study was to determine whether confirmed hypertension, prospectively diagnosed with strict criteria, is an independent risk factor for aneurysmal SAH. Methods-A case-control study was conducted in 2 colombian cities between July 2004 and June 2005. There were 163 new cases of SAH (mean age 51 years; 107 were women) with 2 controls per case: 1 hospital and 1 community control. Hypertension was defined according to cardiovascular criteria, based on target organ damage. In addition to hypertension, other variables were studied: present smoking, recent alcohol consumption, alcohol dependency, coffee consumption, cocaine use, and body mass index. A multivariate logistic regression model was used to determine whether hypertension was an independent risk factor. Results-Among the studied variables, including confirmed hypertension, only present smoking became an independent risk factor for SAH. Conclusions-Confirmed hypertension is not an independent risk factor for aneurysmal SAH. Key Words: subarachnoid hemorrhage Ⅲ risk factors Ⅲ aneurysm Ⅲ hypertension Ⅲ cigarette smoking I nitial bleeding impact accounts for most deaths in aneurysmal subarachnoid hemorrhage (SAH); mortality could decrease if incidence rate is reduced, and then it is necessary to identify risk factors, of which only cigarette smoking is indisputable. All other variables, including hypertension, are still subject to debates. [1][2][3] The study of hypertension in SAH is problematic as patients, because of Cushing reflex, frequently show elevated blood pressure, irrespective of being or not hypertensive. 4 The aim of this study was to determine whether confirmed hypertension, prospectively diagnosed with target organ damage criteria, is an independent risk factor for SAH. Subjects and MethodsA case-control study with incident SAH cases was performed, with patients hospitalized in San Vicente de Paul Hospital, Hospital General, and Clinica Leon XIII from Medellin, or in Hospital Evaristo Moreno from Cali (Colombia). Two controls per case were selected: 1 hospital and 1 community control. Hospitalized controls were patients with nontraumatic acute abdomen (appendicitis, cholecystitis, among others) and community controls were cases' friends. Sampling size was calculated to detect an Odds Ratio of 2.0, with an expected proportion of 15.7% of hypertension among controls, and a case-control ratio of 1:2; thus, 159 cases and 318 controls were included. The studied variables were: SAH (independent), cigarette smoking (in addition with the 6-item Fagerstrom test for nicotine dependence, with a 0 to 10 score), 5 recent alcohol consumption, alcohol dependency according to CAGE questionnaire, 2 confirmed hypertension (fulfilling 1 of these criteria: antihypertensive medication intake previously to SAH prescribed by a physician, hypertension preceding SAH confirmed by a physician; if criteria 1 and 2 were ...

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Family History and Risk of Subarachnoid Hemorrhage

Cited by 53 publications

References 47 publications

Dietary antioxidant intake and risk of an aneurysmal rupture subarachnoid hemorrhage in Japan

Dietary antioxidant intake and risk of an aneurysmal rupture subarachnoid hemorrhage in Japan

Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population

Risk of Aneurysmal Subarachnoid Hemorrhage

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