1970
DOI: 10.1177/003693307001500605
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The Familial Hyperlipoproteinaemias

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“…Nevertheless, most authorities are in agreement that peripheral vascular, cerebrovascular and coronary heart disease are more common [I, 10,12]. This relationship has usually been attributed to the coexisting type II hyperlipoproteinaemia [8], However, an increase in the apparent internal viscosity of red cells produces a most noticeable effect at the level of microcirculation. When the calibre of a vessel reaches a critical size, a small reduction in ery throcyte deformability causes an abrupt increase in flow resistance.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, most authorities are in agreement that peripheral vascular, cerebrovascular and coronary heart disease are more common [I, 10,12]. This relationship has usually been attributed to the coexisting type II hyperlipoproteinaemia [8], However, an increase in the apparent internal viscosity of red cells produces a most noticeable effect at the level of microcirculation. When the calibre of a vessel reaches a critical size, a small reduction in ery throcyte deformability causes an abrupt increase in flow resistance.…”
Section: Discussionmentioning
confidence: 99%