Blood Viscosity in Hyperthyroid and Hypothyroid Patients

Dintenfass, L.; Forbes, C. D.; McDougall, I. Ross

doi:10.1159/000214073

Cited by 5 publications

(6 citation statements)

References 7 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This paper represents a continuation of the studies reported earlier by D intenfass et al [6], and intends to describe certain significant correlations between blood viscosity factors (such as aggregation of red cells, blood viscosity, rigidity of red cells), as also fibrinogen levels, and radioiodine uptake. Perhaps the most interesting feature of this study was a finding that rigidity of red cell and radioiodine uptake are linearly related both for hypo thyroid and hyperthyroid patients.…”

Section: Introductionmentioning

confidence: 54%

“…The potential importance of this field of exploration might justify elabo ration of the formerly reported study [6] on blood viscosity in hypothyroid and hyperthyroid patients.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical details and methodology have been reported [6]. At the time of study the radioiodine uptake and protein bound (PB) 121I test were carried out on all patients, while T3 and serum T4 tests were carried out only on a few of them.…”

Section: Methodsmentioning

confidence: 99%

“…Blood viscosity, erythrocyte sedimentation rates, aggregation of red cells, and deter mination of apparent viscosity of artificial thrombi in vitro were defined as described previously [2,3,5,6].…”

Section: Methodsmentioning

confidence: 99%

“…Rigidity of red cells was estimated by calculation of term 'Tk' from the blood viscosity equation % = (1-kTH) exp -2.5, after D intenfass [1,2,4] and D intenfass et al [6]. ; r = correlation coefficient; p = signi ficance limit of the correlation coefficient; TkH = term Tk is calculated using haematocrit as measure of volume of red cells; Tkp = term Tk is calculated using sedimentation volume after 24 h as a measure of volume of red cells; pF = P, ratio of the apparent inter nal viscosity of the red cell to the viscosity of plasma, is calculated from Tkp.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

Correlations between Radioiodine Uptake and Blood Viscosity Factors in Hypothyroid and Hyperthyroid States

Dintenfass¹

1976

Pathophysiol Haemos Thromb

Self Cite

View full text Add to dashboard Cite

A study of blood viscosity factors was undertaken in six hypothyroid and eleven thyrotoxic patients (females) whose thyroid function was defined by means of radioiodine uptake and protein bound (PB) ¹³¹I tests. Results indicate that: (i) significant differences exist between hypothyroid and hyperthyroid groups in correlations between radioiodine tests and blood viscosity factors (and fibrinogen levels); (ii) blood viscosity in thyrotoxic patients decreases as the degree of thyrotoxicity increases, while an opposite phenomenon is observed in hypothyroid patients, and (iii) degree of rigidity of the red cells is associated with the radioiodine uptake and PB ¹³¹I tests, the correlations being significant and negative.

show abstract

Section: Introductionmentioning

confidence: 54%

“…The potential importance of this field of exploration might justify elabo ration of the formerly reported study [6] on blood viscosity in hypothyroid and hyperthyroid patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Correlations between Radioiodine Uptake and Blood Viscosity Factors in Hypothyroid and Hyperthyroid States

Dintenfass¹

1976

Pathophysiol Haemos Thromb

Self Cite

View full text Add to dashboard Cite

show abstract

Hypothyroidism and the influence on human blood rheology

Költringer

Eber²,

Wakonig³

et al. 1988

J Endocrinol Invest

View full text Add to dashboard Cite

Viscoelastic properties of human whole blood were measured in 338 subjects: 110 persons (75 F, 35 M) following total thyroidectomy but without substitution therapy over three weeks as well as 228 healthy control subjects (124 F, 104 M) were investigated in this study. Subjects with other variable factors were excluded. The viscous and the elastic portion of apparent whole blood viscosity -the latter subdivided into red cell aggregation and red cell rigidity were determined by using a newly developed oscillating capillary rheometer and densitymeter at the real hematocrit value and at a computed hematocrit of 40%. Serum viscosity, hematocrit (Hct), hemoglobin (Hb), mean corpuscular volume of red blood cells (MCV), free triiodothyronine (fT3), free thyroxine (fT4) and serum-thyrotropin (bTSH) were evaluated as well. In a further subgroup of 80 subjects (40 patients with hypothyroidism, 40 healthy control persons) additional plasma viscosity and sedimentation rate were determined. Red cell aggregation and blood viscosity especially at shear-rates below 10/sec increased significantly in hypothyroid patients. There was no significant difference of red cell rigidity, serum viscosity, plasma viscosity and sedimentation rate as against euthyroids. So new aspects of thyroid dysfunction could be described probably with consequences for therapy and for considerations about the development of atherosclerosis and ischemic disorders.

show abstract

The Hyperviscosity Syndromes

Ciufetti¹,

Lombardini²

2003

Semin Thromb Hemost

View full text Add to dashboard Cite

A major determinant of normal blood flow is its fluidity. The physical laws governing fluidity are complex, involving the rheologic properties of both the plasma and the cellular components. Viscosity is an important rheological characteristic of blood and gives the inherent resistance to blood flow. In addition, the vessel size and rate of flow, as well as the characteristics of the cellular components, of blood are among various factors governing blood flow. Any changes in these parameters would lead to an impaired flow and result in failure of delivering adequate oxygen and nutrients to tissues. In the early stages, this affects the microcirculation and is less apparent than when major thromboembolic events take place. Clinically, serious impediment of blood flow can occur, complicating many diseases; this is designated as the hyperviscosity syndrome. The better-known ones are in polycythemia vera, when the hematocrit becomes abnormally high, or in plasma cell dyscrasias, when the plasma proteins levels are elevated. Yet there are many other disorders with hyperviscosity that are receiving less attention. The resulting impaired blood flow is often the pathogenic basis of many diseases. A number of factors can lead to increased blood viscosity, including changes in the plasma proteins or changes in the cellular content. Abnormalities in the former may lead to changes in the latter. For example, abnormal plasma proteins can cause increased red cell aggregation. Although the ultimate complication of thrombosis in the larger vessels is widely recognized, the occlusion of the microcirculation receives much less attention. Furthermore, the in vitro methods commonly used to detect abnormal viscosity are not sophisticated enough to yield useful information on the in vivo status, nor are there uniform methods for the detection of increased red cell aggregation.It is the objective of this issue of Seminars in Thrombosis and Hemostasis to provide the clinician and the basic scientist with updated information on the hyperviscosity syndromes. The first article by Baskurt and Meiselman will familiarize the readers with the principles of rheology of blood and plasma. It paves the way for a comprehensive understanding of the fundamentals, such as the role of shear rate, red cell deformability, and plasma proteins. They also describe how red cell aggregation affects the microcirculation and the importance of rheological factors in tissue perfusion. This is followed by a series of articles describing the clinical disorders often complicated by hyperviscosity. The first article, by Kwaan and Wang, is on the red cell abnormalities as seen in polycythemia vera and a number of conditions associated with increased red cell aggregation. Abnormalities in the leukocytes and factors leading to leukostasis in leukemia, as well as excessive rouleaux formation in rheumatoid arthritis, are then discussed by Rampling. The following article by Mehta and Singhal describes the effect of abnormal gammaglobulins as seen in multiple myeloma and Wa...

show abstract

Blood Viscosity in Hyperthyroid and Hypothyroid Patients

Cited by 5 publications

References 7 publications

Correlations between Radioiodine Uptake and Blood Viscosity Factors in Hypothyroid and Hyperthyroid States

Correlations between Radioiodine Uptake and Blood Viscosity Factors in Hypothyroid and Hyperthyroid States

Hypothyroidism and the influence on human blood rheology

The Hyperviscosity Syndromes

Contact Info

Product

Resources

About