The False Negative Rate in Cervical Cytology

Sprenger, E; Schwarzmann, Peter; Kirkpatrick, Marilyn; Fox, William M.; Heinzerling, Rollin H.; Geyer, James W.; Knesel, Ernest A.

doi:10.1159/000333588

Cited by 46 publications

(7 citation statements)

References 24 publications

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“…Results obtained from uterine cervix examination, for example, have shown that the liquid-based preparations reduce the problems related to sampling error, poor transfer and fixation of the cellular sample [ 20 - 24 ]. In cervical uterine cancer screening, the liquid-based preparations have also demonstrated a significant reduction in false-negative rates as compared with those of conventional smears [ 20 - 23 , 25 ]. In a recent study from Brazil [ 26 ] the liquid-based preparations resulted in higher specimen resolution as well as presenting a better cytological morphology for pemphigus vulgaris, squamous cell carcinomas, HSV lesions and fungus infections.…”

Section: Cytological Techniquesmentioning

confidence: 99%

Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions

et al. 2006

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Early detection of a premalignant or cancerous oral lesion promises to improve the survival and the morbidity of patients suffering from these conditions. Cytological study of oral cells is a nonaggressive technique that is well accepted by the patient, and is therefore an attractive option for the early diagnosis of oral cancer, including epithelial atypia and squamous cell carcinoma. However its usage has been limited so far due to poor sensitivity and specificity in diagnosing oral malignancies. Lately it has re-emerged due to improved methods and it's application in oral precancer and cancer as a diagnostic and predictive method as well as for monitoring patients. Newer diagnostic techniques such as "brush biopsy" and molecular studies have been developed. Recent advances in cytological techniques and novel aspects of applications of scraped or exfoliative cytology for detecting these lesions and predicting their progression or recurrence are reviewed here.

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Section: Cytological Techniquesmentioning

confidence: 99%

Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions

et al. 2006

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“…In the conventional preparation, multiple exfoliated cells are spread out on multiple glass slides immediately after the collection of the cells. The advantages of LBC were that there were fewer airdried artefacts and less contamination with imprecise elements such as blood or debris [21,34,35]. Furthermore, using theliquid-based preparation, it is possible to perform additional analyses such as DNA image cytometry with the same sample of cells [27,36].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma

Deuerling

Gaida

Neumann

et al. 2019

Cancers

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This study evaluates the accuracy of the results of liquid-based oral brush cytology and compares it to the histology and/or the clinical follow-ups of the respective patients. A total of 1352 exfoliated specimens were collected with an Orcellex brush from an identical number of oral lesions, then cytological diagnoses were made using liquid-based cytology. The final diagnoses in the study were 105 histologically proven squamous cell carcinomas (SCCs), 744 potentially malignant lesions and 503 cases of traumatic, inflammatory or benign hyperplastic oral lesions. The sensitivity and specificity of the liquid-based brush biopsy were 95.6% (95% CI 94.5–96.7%) and 84.9% (95% CI 83.0–86.8%), respectively. This led to the conclusion that brush biopsy is potentially a highly sensitive and reliable method to make cytological diagnoses of oral neoplasia. The main advantage of a brush biopsy over a scalpel biopsy is that it is less invasive and is more tolerated by the patients. Therefore, more lesions can be screened and more cancers can be detected at an early stage.

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“…Inadequate sampling is responsible for about two-thirds of examinations with false-negative results [12,13]. Therefore, we can find false-negative results in about 1.5–50% of examinations, depending on the work studied [14,15]. In the present study, 37.2% (42/113) of the cytology results considered normal showed CIN in histology.…”

Section: Discussionmentioning

confidence: 44%

Discordance between Cytology and Biopsy Histology of the Cervix: What to Consider and What to Do

Anschau

Gonçalves²

2011

Acta Cytologica

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Objective: Since cytology is the examination utilized for the screening of cervical cancer, it is important to determine its correlation with histologic examination, the gold standard in the diagnosis of cervical disease. Study Design: A retrospective evaluation was made of 431 patients who presented with colposcopic indication for cervical biopsy between 2003 and 2007. Results: In 90.8% (289/318) of the patients, cytology showing cervical intraepithelial neoplasia (CIN) was confirmed as CIN in the histology of the cervix, while 62.8% (71/113) of patients with normal cytology had a confirmation of a normal histology (ĸ = 0.558). Conclusion: Cytology demonstrated a sensitivity and specificity of 87.3 and 71.0%, respectively. The agreement between cervical cytology and histology, considering the presence of CIN, was moderate. Correlations between accuracy and errors of cytology are discussed with therapeutic emphasis.

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The False Negative Rate in Cervical Cytology

Cited by 46 publications

References 24 publications

Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions

Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions

Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma

Discordance between Cytology and Biopsy Histology of the Cervix: What to Consider and What to Do

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