The False-Negative Fraction: A Statistical Method to Measure the Efficacy of Cervical Smear Screening Laboratories

Dolinar, J; Ollayos, Curtis W.; Tellado, Miguel; Ali, Izzat S.; Stevens, A; Paquette, Cherie; Brodbelt, S

doi:10.1093/milmed/164.6.410

Cited by 3 publications

(3 citation statements)

References 1 publication

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“…The equation for calculating the false-negative fraction was false-negative cases/(false-negative cases + true-positive cases). 24,25 The satisfaction of clinicians was measured indirectly by auditing the number of weekly phone calls received from physicians' offices requesting cytologic reports. Before FPGS and lean principles implementation, the mean total cycle time was 158.48 hours; the value and nonvalue-added times were 12.48 hours and 146.0 hours, respectively.…”

Section: Outcome Metrics and Statistical Analysismentioning

confidence: 99%

The Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology

Wong

Levi²,

Harigopal³

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

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N Context.-Our cytology laboratory, like many others, is under pressure to improve quality and provide test results faster while decreasing costs. We sought to address these issues by introducing new technology and lean principles.Objective.-To determine the combined impact of the FocalPoint Guided Screener (GS) Imaging System (BD Diagnostics-TriPath, Burlington, North Carolina) and lean manufacturing principles on the turnaround time (TAT) and productivity of the gynecologic cytology operation.Design.-We established a baseline measure of the TAT for Papanicolaou tests. We then compared that to the performance after implementing the FocalPoint GS Imaging System and lean principles. The latter included value-stream mapping, workflow modification, and a first in-first out policy.Results.-The mean (SD) TAT for Papanicolaou tests before and after the implementation of FocalPoint GS Imaging System and lean principles was 4.38 (1.28) days and 3.20 (1.32) days, respectively. This represented a 27% improvement in the average TAT, which was statistically significant (P , .001). In addition, the productivity of staff improved 17%, as evidenced by the increase in slides screened from 8.85/h to 10.38/h. The false-negative fraction decreased from 1.4% to 0.9%, representing a 36% improvement.Conclusions.-In our laboratory, the implementation of FocalPoint GS Imaging System in conjunction with lean principles resulted in a significant decrease in the average TAT for Papanicolaou tests and a substantial increase in the productivity of cytotechnologists while maintaining the diagnostic quality of gynecologic cytology.

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Section: Outcome Metrics and Statistical Analysismentioning

confidence: 99%

The Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology

Wong

Levi²,

Harigopal³

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

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show abstract

“…Currently, there is no simpler and more economic method for cervical cancer screening than Papanicolaou (Pap) smears. Since its introduction in 1943, a lot has been written about the specificity and sensitivity of this method, which has false-negative rates ranging from 0 to 94% [1][2][3][4][5][6][7][8][9]. In Venezuela, false-positive reports have been reported between 1 and 30% [10,11].…”

Section: Introductionmentioning

confidence: 99%

Cyto-colpo-histological Study in Sexual Workers

Núñez¹,

Delgado²,

Pino³

et al. 2001

JOURNAL OF LOWER GENITAL TRACT DISEASE

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Objective. To determine the false-negative, false-positive, sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) rates of Pap smears and colposcopy in sexual workers.Materials and Methods. Four hundred thirty-eight prostitutes were given a gynecological examination, Pap smear, and colposcopic examination of the cervix. A cervical biopsy was taken under colposcopic guidance when there was abnormal epithelium.Results. There were 81 premalignant and malignant lesions. Twenty-two Pap smear reports were abnormal: 17 CIN1, four CIN2, and one CIN3. Pap smears had a 14.4% false-negative rate, 0.9% false-positive rate, sensitivity 22.2%, specificity 98.8%, NPV 84.4%, and PPV 81.8%. Eighty-four biopsies were taken from abnormal colposcopic findings, and 96.4% were reported as premalignant and malignant lesions. Colposcopy had a 0.8% false-positive rate, sensitivity 100%, specificity 99.2%, NPV 100%, and PPV 96.4%.Conclusions. Pap smear had a low-sensitivity and colposcopy had a high sensitivity and specificity.

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“…Currently, there is no simpler and more economic method for cervical cancer screening than Papanicolaou (Pap) smears. Since its introduction in 1943, a lot has been written about the specificity and sensitivity of this method, which has false‐negative rates ranging from 0 to 94%[1–9]. In Venezuela, false‐positive reports have been reported between 1 and 30%[10, 11].…”

Section: Introductionmentioning

confidence: 99%

Cyto-colpo-histological Study in Sexual Workers

Núñez

Delgado

Pino

et al. 2001

J Low Genital Tract Dis

View full text Add to dashboard Cite

Objective. To determine the false‐negative, false‐positive, sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) rates of Pap smears and colposcopy in sexual workers. Materials and Methods. Four hundred thirty‐eight prostitutes were given a gynecological examination, Pap smear, and colposcopic examination of the cervix. A cervical biopsy was taken under colposcopic guidance when there was abnormal epithelium. Results. There were 81 premalignant and malignant lesions. Twenty‐two Pap smear reports were abnormal: 17 CIN1, four CIN2, and one CIN3. Pap smears had a 14.4% false‐negative rate, 0.9% false‐positive rate, sensitivity 22.2%, specificity 98.8%, NPV 84.4%, and PPV 81.8%. Eighty‐four biopsies were taken from abnormal colposcopic findings, and 96.4% were reported as premalignant and malignant lesions. Colposcopy had a 0.8% false‐positive rate, sensitivity 100%, specificity 99.2%, NPV 100%, and PPV 96.4%. Conclusions. Pap smear had a low‐sensitivity and colposcopy had a high sensitivity and specificity.

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The False-Negative Fraction: A Statistical Method to Measure the Efficacy of Cervical Smear Screening Laboratories

Cited by 3 publications

References 1 publication

The Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology

The Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology

Cyto-colpo-histological Study in Sexual Workers

Cyto-colpo-histological Study in Sexual Workers

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