The facile and efficient organocatalytic platform for accessing 1,2,4-selenadiazoles and thiadiazoles under aerobic conditions

Organocatalytic Decarboxylation and Dual C(sp3)−H Bond Functionalization Toward Facile Access to Divergent 2,6‐Diarylpyridines

“…With an objective of devising a coherent organocatalytic strategy for the decarboxylation of amino acids and C(sp 3 )−H bond functionalization of aromatic ketones toward the synthesis of pyridines, we began our explorations by choosing acetophenone ( 1 a ) and glycine ( 2 a ) as our model substrates. With the experience of working on the similar cores and organocatalysts, we initiated our experimental studies by screening established organocatalysts [2g,m–o] towards the effective conversion of acetophenone ( 1 a ) and glycine ( 2 a ) in to 2,6‐diphenylpyridine ( 3 aa ) (Table 1). To our surprise, all tested organocatalysts responded fairly under the reaction conditions by giving 2,6‐diarylpyridine ( 3 aa ) in yields ranging from 46–72% (Table 1, entries 1–5).…”

Recent Advances in Pyridine‐Based Organocatalysis and its Application towards Valuable Chemical Transformations

“…The developed reaction conditions make use of vitamin B 3 (nicotinic acid) ( 4 p ) as organocatalyst under aerobic conditions. The method holds good for wide range of thiocarboxamides 48 and selenocarboxamides 49 by delivering the desired products in high yields and selectivity (Scheme ) …”

Development and Therapeutic Potential of Selenazo Compounds

“…The syntheses of 1,2,4-selenadiazoles are scarce, and only a few reports have appeared in the literature recently. , Nevertheless, there is a report concerning biological activity of diferrocenyl-1,2,4-selenadiazoles, demonstrating their antibacterial activity against S. aureus , E. coli , and P. aeruginosa .…”