The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts

Peiris, L.D.C.; Pacheco, Ivan; Spencer, Craig; Macleod, John

doi:10.1152/ajpgi.00225.2006

Cited by 43 publications

(51 citation statements)

References 45 publications

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“…calcium-sensing receptor activation (29,55). We showed a marked increase of BMP2 expression in TNBS colitis and its reduction following BMP7 treatment.…”

Section: Discussionmentioning

confidence: 71%

“…It was shown that upregulated CTGF inhibits BMP4 and BMP7 activity leading to deficiency of BMP signaling (1,53,64). Also, noggin has a reciprocal relationship with BMP2 in colonic myofibroblasts and coexpression with BMP4 in atherosclerotic lesions of human coronary arteries (13,55). Overexpression of noggin caused the absence of Smad 1/5/8 signaling and a disease similar to JP, whereas its downregulation showed opposite effect on different types of arthritis (27,43).…”

Section: Discussionmentioning

confidence: 99%

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BMP signaling in rats with TNBS-induced colitis following BMP7 therapy

Marić¹,

Kučić

Wensveen

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

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yond stimulating bone formation, bone morphogenetic proteins (BMPs) are important in development, inflammation, and malignancy of the gut. We have previously shown that BMP7 has a regenerative, anti-inflammatory, and antiproliferative effect on experimental inflammatory bowel disease (IBD) in rats. To further investigate the BMP signaling pathway we monitored the effect of BMP7 therapy on the BMP signaling components in the rat colon during different stages of experimentally induced colitis by 2,4,6-trinitrobenzene sulfonic acid (TNBS). The results showed a significantly decreased BMP7 expression in the acute phase, followed by a significantly increased BMP2 and decreased BMP6 expression during the chronic phase of colitis. BMP7 therapy influenced the expression of several BMPs with the most prominent effect on downregulation of BMP2 and upregulation of BMP4 in the chronic phase of colitis. Importantly, connective tissue growth factor and noggin expression were elevated in the acute stage and significantly decreased upon BMP7 therapy. BMP receptor I expression was unchanged, whereas BMP receptor II was decreased at day 2 and increased at days 14 and 30 of TNBS inflammation. However, an opposite pattern of expression following BMP7 therapy has been observed. BMP7 increased the expression of BR-Smad including Smad3 and Smad4. Inhibitory Smads were increased in colitis and significantly decreased following BMP7 therapy at later stages of the disease. We suggest that BMP signaling was altered during TNBS-induced colitis and was recovered with BMP7 administration, suggesting that IBD is a reversible process.

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“…calcium-sensing receptor activation (29,55). We showed a marked increase of BMP2 expression in TNBS colitis and its reduction following BMP7 treatment.…”

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

BMP signaling in rats with TNBS-induced colitis following BMP7 therapy

Marić¹,

Kučić

Wensveen

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

show abstract

“…Quantitation of the phosphorylation of p44/42 was done using an ImageQuant and a Personal Densitomenter (Molecular Dynamics). HT-29 cells were treated as previously described (33,38).…”

Section: Methodsmentioning

confidence: 99%

“…Several candidate regions of the CaSR nucleotide sequence were used to generate small interfering (si)RNA duplex constructs as previously described (33,38). We first found 13 potential siRNA target sites in the extracellular domain of the CaSR.…”

Section: Methodsmentioning

confidence: 99%

The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A)

Justinich

Mak²,

Pacheco³

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…4). It was also shown that activation of extracellular calcium-sensing receptor (CaSR), expressed on the epithelia of the GI tract and myofibroblasts, downregulated BMP4 and noggin expression and raises the effective concentration of BMP2 leading to increased intestine repair and barrier development (Peiris et al, 2007). …”

Section: Bmps and Their Signaling Pathway In The Normal Gastrointestimentioning

confidence: 99%

Bone Morphogenetic Proteins and Signaling Pathway in Inflammatory Bowel Disease

Marić¹,

Wensveen²,

Smoljan³

et al. 2012

Inflammatory Bowel Disease - Advances in Pathogenesis and Management

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The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts

Abstract: Peiris D, Pacheco I, Spencer C, MacLeod RJ. The extracellular calcium-sensing receptor reciprocally regulates the secretion of BMP-2 and the BMP antagonist Noggin in colonic myofibroblasts.

Cited by 43 publications

References 45 publications

BMP signaling in rats with TNBS-induced colitis following BMP7 therapy

BMP signaling in rats with TNBS-induced colitis following BMP7 therapy

The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A)

Bone Morphogenetic Proteins and Signaling Pathway in Inflammatory Bowel Disease

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