The Extent of Immunological Privilege of Orthotopic Corneal Grafts in the Inbred Rat

Katami, M; Madden, Peter; White, David J.; Watson, Peter; Kamada, Naoshi

doi:10.1097/00007890-198909000-00003

Cited by 25 publications

(7 citation statements)

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“…There is increasing evidence from recent studies that minor antigens could play a role in corneal allograft rejection. It has been shown that minor H-only disparate orthotopic corneal grafts experience very high rates of irreversible rejection (Katami et al, 1989 ;Ross et al, 1989 ;Vetto and Burger, 1972).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Tissue Culture on Corneal Immunogenicity

Gabrić¹,

Dekaris²,

Šuman

et al. 1999

Experimental Eye Research

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Section: Discussionmentioning

confidence: 99%

The Influence of Tissue Culture on Corneal Immunogenicity

Gabrić¹,

Dekaris²,

Šuman

et al. 1999

Experimental Eye Research

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“…More recently, matching for the H-Y minor histocompatibility antigen has also been shown to improve human corneal graft survival (82). The evidence from animal models certainly supports a role for minor transplantation antigens being important in the immune response to a corneal graft (83).…”

Section: Role Of Histocompatibility Antigen Matching In Corneal Transmentioning

confidence: 96%

The Immunobiology of Corneal Transplantation

Williams

Coster

2007

Transplantation

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Corneal allotransplantation is highly successful in the short term, but much less successful in the longer term. Many corneal grafts in recipients with corneal neovascularization or the sequelae of ocular inflammation undergo irreversible rejection, despite topical immunosuppression with glucocorticosteroids. Sensitization to cornea-derived alloantigen proceeds by both direct and indirect routes, but the anatomic location of sensitization remains unclear. Multiple and redundant mechanisms operate in the effector phase of corneal graft rejection, which is largely cell-mediated rather than antibody-mediated. Human leukocyte antigen matching may improve outcomes in high-risk patients but systemic immunosuppression is frequently ineffective and is seldom used.

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“…30 It is the bone-marrow-derived cells, the interstitial dendritic cells, that process alloantigens and present them to the host immunocyte. This occurs in the ocular environs and local lymph nodes.…”

Section: Mechanisms Of Corneal Allograft Rejectionmentioning

confidence: 99%

Management of high-risk corneal grafts

Coster¹,

Williams²

2003

Eye

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Corneal transplantation is not invariably successful despite the anterior chamber of the eye being an immunologically privileged site. Inflammation erodes privilege. Other than by reducing inflammation through meticulous surgery, careful postoperative surveillance, and effective topical corticosteroids in the postoperative phase, there is little that a surgeon can do to improve the outlook for the majority of patients receiving corneal transplants. For patients at appreciable risk, HLA Class I matching may help where it is available. So too will systemic immunosuppression where it can be justified. Despite these measures, the results of corneal transplantation have not shown the improvement seen in solid organ transplantation over the last 30 years. New approaches applicable to corneal transplantation are required.

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The Extent of Immunological Privilege of Orthotopic Corneal Grafts in the Inbred Rat

Cited by 25 publications

References 0 publications

The Influence of Tissue Culture on Corneal Immunogenicity

The Influence of Tissue Culture on Corneal Immunogenicity

The Immunobiology of Corneal Transplantation

Management of high-risk corneal grafts

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