1999
DOI: 10.1006/exer.1998.0616
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The Influence of Tissue Culture on Corneal Immunogenicity

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“…A similar observation was made by Ardjomand et al, who found a significantly better success rate in those patients who received grafts stored for more than 5 days than in patients who received grafts stored for less than 6 days [1]. One possible explanation for this phenomenon is the observation that storage of corneas leads to loss of corneal Langerhans cells [2,22], even though -in an experimental mouse model -storage of corneas in a tissue culture did not cause a loss of the ability to sensitize multiple minor H-disparate hosts [11].…”
Section: Discussionmentioning
confidence: 93%
“…A similar observation was made by Ardjomand et al, who found a significantly better success rate in those patients who received grafts stored for more than 5 days than in patients who received grafts stored for less than 6 days [1]. One possible explanation for this phenomenon is the observation that storage of corneas leads to loss of corneal Langerhans cells [2,22], even though -in an experimental mouse model -storage of corneas in a tissue culture did not cause a loss of the ability to sensitize multiple minor H-disparate hosts [11].…”
Section: Discussionmentioning
confidence: 93%