The expression of trophoblastic cell markers by lung carcinomas

Boucher, Leslie D.; Yoneda, K

doi:10.1016/0046-8177(95)90194-9

Cited by 46 publications

(23 citation statements)

References 25 publications

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“…They also found that 28% of resected NSCLC specimens showed positive immunohistochemical staining for β-hCG, although the positive results in previous reports differ widely, from 9% (6) to 84% (7). Positive staining was more common in adenocarcinoma (10/27, 37%) than in SCC (5/26, 19%) (5), which was consistent with another report (adenocarcinoma 60%, SCC 21%) (8).…”

Section: Discussionsupporting

confidence: 90%

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Secretion of hCG/beta-hCG by Squamous Cell Carcinoma of the Lung in a 31-year-old Female Smoker

Nagai¹,

Nishimura²,

Takahashi³

et al. 2000

Japanese Journal of Clinical Oncology

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Abbreviations: hCG, human chorionic gonadotropin; β-hCG, β-subunit of human chorionic gonadotropin; SCC, squamous cell carcinoma; HB, hepatitis type B; NSCLC, non-small cell lung cancer We describe a rare case of pulmonary squamous cell carcinoma secreting human chorionic gonadotropin (hCG) and its β-subunit (β-hCG) in a young female smoker. A 31-year-old mother of one child had been suffering from dysfunctional uterine bleeding for about 1 year. Pelvic examinations and abdominal ultrasonography yielded no abnormal findings and no signs of pregnancy. She developed a pain in the right chest and a huge (12 × 10 cm) squamous cell carcinoma was diagnosed in the right lower lobe. The serum hCG and β-hCG levels were high: hCG 5611 mIU/ml (normal upper limit 0.7 mIU/ml), β-hCG 12 238 mIU/ml (normal upper limit 0.5 mIU/ml). The patient underwent right lower lobectomy and systematic lymph node dissection. Microscopic study showed a poorly differentiated squamous cell carcinoma. The pathological stage was T2N0M0, stage IB. Immunohistochemical staining of the tumor was strongly positive for hCG. The serum hCG level returned to normal 1 month after the operation, while an additional 2 months were necessary for the β-hCG level to normalize. Dysfunctional uterine bleeding disappeared and the patient is doing well, with no signs of recurrence, 9 months after the resection.

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Section: Discussionsupporting

confidence: 90%

“…Although pulmonary carcinoma secreting human chorionic gonadotropin (hCG) is not uncommon (5)(6)(7)(8), the number of case reports on hCGproducing lung cancer, especially in women, is limited (9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Secretion of hCG/beta-hCG by Squamous Cell Carcinoma of the Lung in a 31-year-old Female Smoker

Nagai¹,

Nishimura²,

Takahashi³

et al. 2000

Japanese Journal of Clinical Oncology

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“…15 Past experiments have also shown that detecting hCG in serous fluids or urine using laboratory methods indicates the presence of malignancy in these specimens. 7,8,16 Prior reports indicate that 31-42% of malignant effusions will have elevated hCG levels as compared to benign effusions using laboratory methods. The specificity of hCG as a laboratory test for malignant effusions is reported to be over 90%.…”

Section: Discussionmentioning

confidence: 99%

“…Several carcinomas, in addition to trophoblastic tumors, may express hCG, and detection of serum hCG in patients with such carcinomas generally portends a poor prognosis. [5][6][7] Additionally, detection of hCG in serous fluids using various laboratory assays has been associated with the presence of metastases in these specimens. 8,9 However, to date, no study has been published examining hCG as an immunostain in this cytologic setting.…”

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confidence: 99%

The β subunit of human chorionic gonadotropin lacks specificity for malignant cells in serous effusions

Zimmerman

Fogt

2004

Modern Pathology

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The cytologic diagnosis of malignancy is frequently straightforward. For difficult cases, multiple immunostains and immunostain panels have been investigated without consensus. b-human chorionic gonadotropin (hCG) has been reportedly expressed in malignancies, but not in normal tissue. HCG also has been reported as a specific marker of metastases in serous fluids when detected with laboratory assays. We investigated the clinical utility of hCG in this cytologic setting. A total of 97 cases of benign and malignant effusions were studied. Each case was immunostained with monoclonal hCG using the avidin-biotin technique and diaminobenzidine as a chromogen. Additionally, a mucicarmine stain was performed on most cases. Cases were evaluated for hCG expression and mucin in a blinded fashion. After the cases were reviewed, the diagnoses were unblinded and staining patterns were evaluated. Of the 47 benign cases studied, 23 (49%) exhibited immunoreactivity to hCG in at least 5% of mesothelial cells present. In contrast, 28 of 44 (64%) adenocarcionomas exhibited a similar degree of immunostaining. In all, 21 (48%) of the adenocarcinomas were also positive for mucin; five of these mucin-positive cases were negative for hCG. The combination of mucin and hCG detected 33 of 44 (75%) adenocarcinomas. We conclude that hCG lacks the specificity for malignant cells to be of clinical use in effusion cytology.

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“…In addition, many tumors including breast (Wurz et al, 1979), colorectal (Haynes et al, 1985) and lung (Grudzinskas et al, 1980;Boucher and Yoneda, 1995) cancers have been reported to produce SP1. However, many reports on the correlation of serum SP1 level with various clinical conditions show considerable discrepancies from reports to reports in each cancer.…”

Section: Introductionmentioning

confidence: 99%

An enzyme immunoassay for pregnancy-specific β-1 glycoprotein (SP1), employing monoclonal antibodies

Lee

Kim²,

Chung³

1996

Exp Mol Med

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Two-site binding enzyme immunoassay for pregnancy-specific -1 glycoprotein (SP1) has been developed using two monoclonal antibodies which can recognize all the three forms of SP1 from human sera. This assay system detects a minimal concentration of 1.25 ng/ml, and shows a linear dose-response curve at a range between 1.4 and 45.0 ng/ml. The recovery rates ranged from 90.0% to 113.3%, and intra-assay coefficients of variation were 15.8% and 8.7% for two different samples. When compared with a commercial EIA kit, this assay system had high correlation coefficient (r = 0.92) but with somewhat lower values. K e y w o r d s ; enzyme immunoassay, monoclonal antibody, pregnancy-specific β-1 glycoprotein (SP1)

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The expression of trophoblastic cell markers by lung carcinomas

Cited by 46 publications

References 25 publications

Secretion of hCG/beta-hCG by Squamous Cell Carcinoma of the Lung in a 31-year-old Female Smoker

Secretion of hCG/beta-hCG by Squamous Cell Carcinoma of the Lung in a 31-year-old Female Smoker

The β subunit of human chorionic gonadotropin lacks specificity for malignant cells in serous effusions

An enzyme immunoassay for pregnancy-specific β-1 glycoprotein (SP1), employing monoclonal antibodies

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