The expression of RCAS1 and tumor infiltrating lymphocytes in patients with T3 gastric carcinoma

Fukuda, Kenji; Tsujitani, Shunichi; Maeta, Yoshihiko; Yamaguchi, Kensei; Ikeguchi, Masahide; Kaibara, Nobuaki

doi:10.1007/s101200200038

Cited by 39 publications

(38 citation statements)

References 34 publications

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“…The diffuse pattern of gastric cancers was implicated in large size, depth of invasion and regional lymph node metastasis, compared with polarity pattern. Moreover, RCAS1 expression in T3 gastric carcinoma was significantly correlated with the histological type and lymph node metastasis (60).…”

Section: Introductionmentioning

confidence: 92%

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer

Okayama

Kumamoto²,

Saitou³

et al. 2009

Oncol Rep

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Abstract. The aim of this study was to examine the expression of CD44v6, CD54, Cdx2, CXCL5, Cyclin B1, MMP-7, nm23, RCAS1 and Survivin in primary gastric cancer and to investigate whether these molecules were useful in predicting the lymph node status. They were selected as candidates for indicators of lymph node metastasis from various kinds of cancer-associated genes reported previously. In 135 cases of radically resected primary gastric adenocarcinoma, we investigated the association between the expression of these molecules and clinocopathologic factors by immunohistochemistry. The results revealed that the expression of CD44v6 and MMP-7 were significantly associated with lymph node status. By contrast, nuclear Cdx2 expression was found to be inversely correlated with lymph node metastasis. Moreover, multivariate analysis demonstrated that CD44v6, MMP-7 and nuclear Cdx2 were independent predictors for lymph node status. In conclusion, our results suggest that positive expression of both CD44v6 and MMP-7, and negative expression of nuclear Cdx2 may serve as powerful predictors of lymph node metastasis in gastric cancer. Combined evaluation of these markers could be further useful to predict lymph node status clinically.

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Section: Introductionmentioning

confidence: 92%

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer

Okayama

Kumamoto²,

Saitou³

et al. 2009

Oncol Rep

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show abstract

“…Recombinant and soluble RCAS1 inhibit cell proliferation and induce DNA fragmentation of PBLs. Moreover, fragmentation of the DNA in TILs has been observed in RCAS1-expressing human tumors (biliary adenocarcinoma, lung cancer, and gastric cancer) [5,6,13]. The majority of TILs in human tumors are T cells, suggesting an activation of the host defense mechanism [37].…”

Section: Discussionmentioning

confidence: 99%

“…RCAS1 has also been detected in nongynecological cancers such as human breast carcinomas [26,32,36], esophageal squamous cell carcinomas [19], gastric adenocarcinomas [6,16], hepatocellular carcinomas [2,21], lung cancers [13,14,22], and pancreatic adenocarcinomas [1,19]. Expression of RCAS1 is associated with a poor prognosis in these cancer patients.…”

mentioning

confidence: 99%

Expression of a Tumor-Associated Antigen, RCAS1, in Canine Mammary Tumors

Okamura

Haraguchi

Morimoto

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. Receptor-binding cancer antigen expressed on SiSo cells (RCAS1), one of novel cancer cell-surface antigens, is strongly expressed in invasive cancers. RCAS1 inhibits the in vitro growth of lymphocytes such as T cells and natural killer (NK) cells, and induces apoptotic cell death. We investigated the expression of RCAS1 in canine mammary tumor cell lines and tumor cells by immunohistochemistry, and also in situ deoxyribonucleic acid (DNA) fragmentation in tumor-infiltrating lymphocytes (TILs) by the terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labeling (TUNEL) method. All canine mammary tumor cell lines expressed RCAS1 at both the messenger ribonucleic acid (mRNA) and protein level. Immunohistochemically, RCAS1 was negative in 100% of normal mammary glands, but was expressed in 100% of malignant tumors examined. In most malignant mammary tumors, RCAS1 was localized in the cytoplasm with no polarity of expression. In benign mammary tumors, it was detected on the luminal surface of the tumor cell. RCAS1 expression or localization was significantly correlated with malignancy. In situ DNA fragmentation of CD3-positive TILs was observed in RCAS1-expressing tumors. RCAS1-expressing tumors, indicating a possible induction of apoptotic cell death in TILs through RCAS1 expression. These observations suggest that RCAS1 probably plays an important role in tumor progression and escape from immune surveillance in canine mammary tumors. KEY WORDS: canine mammary tumor, DNA fragmentation, immunohistochemistry, receptor-binding cancer antigen expressed on SiSo cells (RCAS1), tumor infiltrating lymphocyte (TILs).

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“…4-1 (Fig. 4-2 (18,19), gastric cancer (20,21), colon cancer (22,23), breast cancer (24), hepatocellular carcinoma (25), and bladder cancer (26). Ropponen et al showed that the level of infiltration in TILs is correlated with the prognosis, and when the level of infiltration is high, the prognosis is good (27).…”

Section: Correlation Between the Lymphocyte Rate In Malignant Pleuralmentioning

confidence: 99%

Influence of Lymphocytes in Malignant Pleural Effusion on the Therapeutic Efficacy of Intrapleural OK-432 in Lung Cancer Patients

et al. 2006

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The expression of RCAS1 and tumor infiltrating lymphocytes in patients with T3 gastric carcinoma

Cited by 39 publications

References 34 publications

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer

CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer

Expression of a Tumor-Associated Antigen, RCAS1, in Canine Mammary Tumors

Influence of Lymphocytes in Malignant Pleural Effusion on the Therapeutic Efficacy of Intrapleural OK-432 in Lung Cancer Patients

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