Influence of Lymphocytes in Malignant Pleural Effusion on the Therapeutic Efficacy of Intrapleural OK-432 in Lung Cancer Patients

Shimizu, Tetsuo; Takahashi, N.; Terakado, Masaaki; Akusawa, Hiroshi; Tsujino, Ichiro; Horie, Takashi

doi:10.2169/internalmedicine.45.1538

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Since the efficacy of chemotherapy is not very high, this disease remains a challenging type of cancer. Various complications appear in advanced lung cancer, among which malignant pleural effusion occurs frequently, at about 10% (15). In malignant pleural effusion, pleural fluid generally increases progressively, which induces dyspnea and markedly reduces the QOL of patients.…”

Section: Introductionmentioning

confidence: 99%

Activation of Vα24NKT cells in malignant pleural effusion in patients with lung cancer

Shimizu

Takahashi²,

Terakado³

et al. 2009

Oncol Rep

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Abstract. V · 24NKT cells are lymphocytes expressing both T-cell antigen receptors and NK-cell antigen receptors on their cell surface and are involved in tumor immunity. They exert their antitumor effects after being activated by a specific ligand, ·-galactosyl ceramide (·-GalCer). Malignant pleural effusion, a frequently occurring complication in patients with lung cancer, contains numerous lymphocytes. In the present study, we examined the presence and functions of V · 24NKT cells in the lymphocytes in pleural effusion in vitro. The subjects were 13 untreated patients with primary lung cancer, who suffered malignant pleural effusion as a complication and who were treated between April 2004 and October 2007 at our hospital. Mononuclear cells were separated from the malignant pleural effusion and incubated with ·-GalCer and IL-12. The production of IFN-Á and IL-4 after incubation and the proportion of the V · 24NKT cells before and after incubation were determined and compared. In the group cultured with ·-GalCer alone, no significant increase in IFN-Á production was observed in comparison with the control group. In the group cultured with ·-GalCer + IL-12, IFN-Á production increased significantly in comparison with the control group, and the proportion of V · 24NKT cells increased after incubation. IL-4 production was very much lower than IFN-Á production. V · 24NKT cells were present in malignant pleural effusion in patients with lung cancer, but IFN-Á production did not increase after addition of ·-GalCer alone. The V · 24NKT cells were activated by ·-GalCer in the presence of IL-12. The V · 24NKT cells in malignant pleural effusion were not activated by ·-GalCer alone, suggesting that V · 24NKT cell function is attenuated in malignant pleural effusion.

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Section: Introductionmentioning

confidence: 99%

Activation of Vα24NKT cells in malignant pleural effusion in patients with lung cancer

Shimizu

Takahashi²,

Terakado³

et al. 2009

Oncol Rep

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“…OK‐432 is a biological response modifier (BRM), which is a penicillin G‐inactivated and lyophilized preparation of the low‐virulence strain Su of Streptococcus pyogenes. 1 OK‐432 is an approved adjuvant therapeutic agent for malignancies in Japan 2 . OK‐432 exerts its effect by activating the immune system to secrete antitumour agents; 3 however, little is known about its in vivo immunological mechanism.…”

mentioning

confidence: 99%

Intratumoral injection of OK-432 suppresses metastatic squamous cell carcinoma lesion inducing interferon-γ and tumour necrosis factor-α

Akeda¹,

Yamanaka²,

Kitagawa³

et al. 2011

Clinical and Experimental Dermatology

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Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture

Yoon

Shin

et al. 2008

Appl Microbiol Biotechnol

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After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 mug/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.

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Influence of Lymphocytes in Malignant Pleural Effusion on the Therapeutic Efficacy of Intrapleural OK-432 in Lung Cancer Patients

Cited by 7 publications

References 25 publications

Activation of Vα24NKT cells in malignant pleural effusion in patients with lung cancer

Activation of Vα24NKT cells in malignant pleural effusion in patients with lung cancer

Intratumoral injection of OK-432 suppresses metastatic squamous cell carcinoma lesion inducing interferon-γ and tumour necrosis factor-α

Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture

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