The Expression of IL–4, IL–6 and TNF–α in the Liver of Food–Sensitized Mice after Oral Challenge

Sakamoto, Yasutoshi; Ueno, Kozo; Yofu, Sachiko; Fujita, Kazunobu; Iíkura, Yoji

doi:10.1159/000024079

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Consistent with this implication, it has been demonstrated that oral tolerance could not be developed in this mouse model, while this was not the case in Balb/c mice (Sakai et al , 2006). Moreover, this mouse model is used as a model for food allergy, which is associated with an elevated level of serum IgE (Sakamoto et al , 1999). Interestingly, abnormality of the intestinal immune system in patients with AD was also reported by Majamaa et al (1996).…”

Section: Discussionmentioning

confidence: 99%

Primary administration ofLactobacillus johnsoniiNCC533 in weaning period suppresses the elevation of proinflammatory cytokines and CD86 gene expressions in skin lesions in NC/Nga mice

Inoüe

Otsuka

Nishio

et al. 2007

FEMS Immunology &Amp; Medical Microbiology

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The administration of probiotic lactic acid bacteria (LAB) has been studied for its potential to prevent atopic dermatitis (AD). The objective of this study was to assess the inhibitory mechanism of a skin lesion by LAB using an experimental model that we previously demonstrated in NC/Nga mice. Lactobacillus johnsonii NCC533 (La1) was administered orally to the La1 group from 20 to 22 days after birth, while phosphate-buffered saline was given to the control group. After the induction of skin lesions in 6-week-old mice, the expression of genes supposedly involved in AD was evaluated. Gene expression of the proinflammatory cytokines [interleukin-8 (IL-8), IL-12 and IL-23] was significantly enhanced in the lesional skin of the control group by the induction of the lesion, whereas gene expression of those in the La1 group was not elevated. Interestingly, expression of the costimulatory molecule CD86 showed a pattern similar to the expression of the cytokines in the lesional skin. Moreover, the La1 group showed a significantly lower gene expression of CD86 in Peyer's patches and mesenteric lymph nodes than the control group. The suppression of proinflammatory cytokines and CD86 by primary administration of La1 may significantly contribute to the inhibitory effect on the skin lesion.

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Section: Discussionmentioning

confidence: 99%