The expression levels of long noncoding RNAs lnc0640 and lnc5150 and its gene single‐nucleotide polymorphisms in rheumatoid arthritis patients

Zhang, Tian‐Ping; Zhang, Qin; Wu, Jun; Zhao, Yulan; Wang, Jie‐Bing; Leng, Rui‐Xue; Fan, Yin‐Guang; Li, Xiaomei; Pan, Hai‐Feng; Ye, Dong‐Qing

doi:10.1002/jcb.27346

Cited by 11 publications

(8 citation statements)

References 37 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LncRNAs are reported to be involved in a variety of autoimmunity- and inflammation- related processes, and regulate gene expression in multiple mechanisms including alternative splicing, epigenetics, small RNA sponging (10, 11). Increasing studies have been performed to explore the potential role of lncRNAs on the pathogenesis of autoimmune diseases, such as RA and systemic lupus erythematosus (SLE) (12–14). Our recent study demonstrated that the lnc0640, lnc5150 expression levels were alternated among RA patients, and lnc0640 rs13039216 TT genotype was statistically associated with RA susceptibility (14).…”

Section: Introductionmentioning

confidence: 99%

“…Increasing studies have been performed to explore the potential role of lncRNAs on the pathogenesis of autoimmune diseases, such as RA and systemic lupus erythematosus (SLE) (12–14). Our recent study demonstrated that the lnc0640, lnc5150 expression levels were alternated among RA patients, and lnc0640 rs13039216 TT genotype was statistically associated with RA susceptibility (14). Another previous study suggested that aberrant lncRNA expression level in peripheral blood mononuclear cells (PBMCs) could be a potential biomarker for RA diagnosing (13).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long Non-coding RNAs Genes Polymorphisms and Their Expression Levels in Patients With Rheumatoid Arthritis

et al. 2019

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are increasingly recognized to play important roles in multiple autoimmune diseases. This study aimed to evaluate the association of four lncRNAs (ANRIL, lnc-DC, MALAT1, ZFAS1) genes single nucleotide polymorphisms (SNPs) with susceptibility to rheumatoid arthritis (RA) patients, as well as their expression levels. Seventeen SNPs of the four lncRNAs were genotyped in a cohort of 660 RA patients and 710 controls using improved multiple ligase detection reaction (iMLDR). The lncRNAs expressions in peripheral blood mononuclear cells (PBMCs) from 120 RA patients and 120 controls were detected by qRT-PCR. No significant differences were found for the allele and genotype frequencies distribution of ANRIL SNPs (rs1412830, rs944796, rs61271866, rs2518723, rs3217992), lnc-DC SNPs (rs7217280, rs10515177), MALAT1 SNPs (rs619586, rs4102217, rs591291, rs11227209, rs35138901), ZFAS1 SNPs (rs237742, rs73116127, rs6125607, rs6125608) between RA patients and normal controls (all P > 0.05). The genotype effects of dominant and recessive models were also evaluated, but no significant association was found. In addition, our results demonstrated that the rs944796 G allele, rs2518723 T allele, rs3217992 T allele frequencies were significantly associated with anti-CCP in RA patients (all P < 0.05). The haplotype CGTA frequency for ZFAS1 was significantly higher in RA patients (P = 0.036). Compared with normal controls, the expression levels of ANRIL, lnc-DC, MALAT1, ZFAS1 in PBMCs were significantly reduced in RA patients (all P < 0.001). Moreover, ZFAS1 expression was negatively associated with CRP in RA patients (P = 0.002). In summary, ANRIL, lnc-DC, MALAT1, and ZFAS1 genes SNPs were not associated with RA susceptibility, while altered ANRIL, lnc-DC, MALAT1, ZFAS1 levels in RA patients suggested that these lncRNAs might play a role in RA.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNAs Genes Polymorphisms and Their Expression Levels in Patients With Rheumatoid Arthritis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Single nucleotide polymorphism (SNP) plays key role in disordered lncRNA (Castellanos-Rubio and Ghosh, 2019). For example, Zhang et al (2018) found that the level of lnc0640 in the PBMCs of RA patients was significantly increased compared with control, while the level of lnc5150 was significantly reduced. The disordered lnc0640 and lnc5150 were correlated with CRP, and the lnc5150 was correlated with the ESR.…”

Section: Lncrnas In Pbmcsmentioning

confidence: 99%

Dysregulation of lncRNAs in Rheumatoid Arthritis: Biomarkers, Pathogenesis and Potential Therapeutic Targets

et al. 2021

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology, mainly manifested by persistent abnormal proliferation of fibroblast-like synoviocytes (FLSs), inflammation, synovial hyperplasia and cartilage erosion, accompanied by joint swelling and joint destruction. Abnormal expression or function of long noncoding RNAs (lncRNAs) are closely related to human diseases, including cancers, mental diseases, autoimmune diseases and others. The abnormal sequence and spatial structure of lncRNAs, the disorder expression and the abnormal interaction with the binding protein will lead to the change of gene expression in the way of epigenetic modification. Increasing evidence demonstrated that lncRNAs were involved in the activation of FLSs, which played a key role in the pathogenesis of RA. In this review, the research progress of lncRNAs in the pathogenesis of RA was systematically summarized, including the role of lncRNAs in the diagnosis of RA, the regulatory mechanism of lncRNAs in the pathogenesis of RA, and the intervention role of lncRNAs in the treatment of RA. Furthermore, the activated signal pathways, the role of DNA methylation and other mechanism have also been overview in this review.

show abstract

“…previously identified two novel lncRNAs, lnc0640 and lnc5150, which played a role in the development of SLE and the effect of lnc0640 and lnc5150 in RA was hereby explored. [24] The expression of lnc0640 in PBMCs of RA patients was significantly increased, whereas the expression of lnc5150 was significantly decreased. And the two lncRNAs were found to be significantly associated with the level of serum CRP.…”

Section: Dysregulated Expression Of Lncrnas In Ramentioning

confidence: 99%

LncRNA: An all-rounder in rheumatoid arthritis

Liang

Chen

Lin

2019

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. In addition to working as biomarkers for RA, lncRNAs participate in many specific pathological processes including inflammation, aberrant proliferation, migration, invasion and apoptosis. Further screenings and researches are required to validate the clinical potentials of lncRNAs as diagnostic and therapeutic targets in RA.

show abstract

The expression levels of long noncoding RNAs lnc0640 and lnc5150 and its gene single‐nucleotide polymorphisms in rheumatoid arthritis patients

Abstract: The expressions of lnc0640 and lnc5150 were alternated in the RA patients, suggesting that these lncRNAs may involve in the development of RA.

Cited by 11 publications

References 37 publications

Long Non-coding RNAs Genes Polymorphisms and Their Expression Levels in Patients With Rheumatoid Arthritis

Long Non-coding RNAs Genes Polymorphisms and Their Expression Levels in Patients With Rheumatoid Arthritis

Dysregulation of lncRNAs in Rheumatoid Arthritis: Biomarkers, Pathogenesis and Potential Therapeutic Targets

LncRNA: An all-rounder in rheumatoid arthritis

Contact Info

Product

Resources

About