The expression and roles of Id1 and Id2 in the aggressive phenotype of human oral squamous cell carcinoma cells

Murase, Ryuichi; Sumida, Tomoki; Liu, Shao hua; Yoshimura, Toshiyuki; Ishikawa, Akiko; Wei, Fengcai; Tano, Tomoyuki; Hamakawa, Hiroyuki

doi:10.1016/j.ajoms.2012.06.003

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…The different members of the ID family show varying expression patterns and functions and localize to different chromosomes (5,6). Previously, we investigated the role of the ID1 protein in oral squamous cell carcinoma (OSCC), which is the most common type of oral cancer, and found that ID1 plays an important role during cancer cell progression (7). ID1 is expressed during proliferation and can suppress differentiation in all cell types examined so far; however, the data on ID2 are much less consistent.…”

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confidence: 97%

Introduction of ID2 Enhances Invasiveness in ID2-null Oral Squamous Cell Carcinoma Cells via the SNAIL Axis

Kamata

Sumida

Kobayashi

et al. 2016

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confidence: 97%

Introduction of ID2 Enhances Invasiveness in ID2-null Oral Squamous Cell Carcinoma Cells via the SNAIL Axis

Kamata

Sumida

Kobayashi

et al. 2016

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“…; Murase et al . ). Over‐expression of ID1 in these cells was able to enhance their malignant phenotype, that is , proliferation, migration and invasion.…”

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confidence: 97%

“…The expression of the helix-loop-helix ID1 has been reported to be up-regulated in head and neck cancer cells Murase et al 2013). Overexpression of ID1 in these cells was able to enhance their malignant phenotype, that is, proliferation, migration and invasion.…”

Section: Discussionmentioning

confidence: 97%

TargetingID2expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells

et al. 2016

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Inhibitors of DNA-binding (ID) proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. We previously determined that ID1 was highly expressed in aggressive salivary gland cancer (SGC) cells in culture. Here, we show that ID2 is also expressed in aggressive SGC cells. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of Ncadherin, vimentin and Snail, induces E-cadherin expression and leads to a more differentiated phenotype exemplified by changes in cell shape. Moreover, ID2 knockdown almost completely suppresses invasion and the expression of matrix metalloproteinase 9. In conclusion, ID2 expression maintains an aggressive phenotype in SGC cells, and ID2 repression triggers a reduction in cell aggressiveness. ID2 therefore represents a potential therapeutic target during SGC progression. ID proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression and leads to a more differentiated phenotype exemplified by changes in cell shape. ID2 therefore represents a potential therapeutic target during SGC progression.

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The expression and roles of Id1 and Id2 in the aggressive phenotype of human oral squamous cell carcinoma cells

Cited by 2 publications

References 30 publications

Introduction of ID2 Enhances Invasiveness in ID2-null Oral Squamous Cell Carcinoma Cells via the SNAIL Axis

Introduction of ID2 Enhances Invasiveness in ID2-null Oral Squamous Cell Carcinoma Cells via the SNAIL Axis

TargetingID2expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells

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