Targeting<i>ID2</i>expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells

Sumida, Tomoki; Ishikawa, Akiko; Nakano, Hirofumi; Yamada, Tomohiro; Mori, Yoshihide; Desprez, Pierre Yves

doi:10.1111/gtc.12389

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…Id proteins are negative regulators of basic helix‐loop‐helix transcription factors and generally stimulate cell proliferation and inhibit differentiation . A couple of mechanisms underlying growth‐regulatory function of Id proteins have been explored.…”

Section: Discussionmentioning

confidence: 99%

“…Activated Smads bind to Smad-binding elements (SBE) on Id promoter resulting in transcription of Id proteins 29. Id proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation 30,31. A couple of mechanisms underlying growth-regulatory function of Id proteins have been explored.…”

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confidence: 99%

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BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling

Zeng

Zhang

et al. 2017

Molecular Carcinogenesis

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Bone morphogenetic protein-4 (BMP4) plays a crucial role in carcinogenesis, but the effects and signaling mechanisms of BMP4 in hepatocellular carcinoma (HCC) are not clearly clarified. The present study aimed to identify the roles of BMP4 in the proliferation of human HCC. In this study, BMP4 expression and its correlation with clinicopathological characteristics and the survival of HCC patients were analyzed in two independent cohorts consisting of 310 subjects. Functional analysis of BMP4 on HCC proliferation was performed in vitro and in vivo in human HCC specimens, HCC cells of Bel-7402 and HCCLM3, and subcutaneous tumor model. The downstream signaling targets of BMP4 in HCC were investigated by PCR Array and Western blot. The results indicated that BMP4 expression was significantly increased in HCC tissues and closely related with unfavorable prognosis of HCC. BMP4 treatment increased cell proliferation and promoted G1/S cell cycle progression. In vivo subcutaneous tumor of nude mice model supported that BMP4 overexpression promoted the growth of HCC cells and BMP4 knockdown hold the opposite trend. Id2 was directly upregulated by BMP4, resulting in the mediated expression of cell cycle regulatory protein of CDKN1B. Blocking of Id2 attenuated BMP4-induced proliferation, confirming the important roles of Id2 in BMP4-mediated proliferation in HCC. So BMP4 is overexpressed in HCC tissues and acts as a poor prognostic factor of HCC patients. BMP4-induced ID2/CDKN1B signaling facilitates proliferation of HCC.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling

Zeng

Zhang

et al. 2017

Molecular Carcinogenesis

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“…ID2 was significantly overexpressed in all CDDP-resistant TGCT cell lines. In other cancers, the ID2 protein promotes early-stage progression [83] and survival during metabolic stress [84], and its defect leads to a more differentiated less aggressive phenotype [85]. We found no significant changes in ISG20 expression, although ISG20 is a protein whose forced expression leads to significant promotion of metastasis and angiogenesis in hepatocellular carcinoma [86].…”

Section: Discussionmentioning

confidence: 53%

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines

et al. 2020

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“…When inflammation and cell proliferation and differentiation appeared, it was induced by cytokines, growth factors and tumor promoters, and its expression could be rapidly increased by 8-10 times. COX-2 is a rate-limiting enzyme of prostaglandin production, which is widely considered as one of the important inducible enzymes in inflammatory process [17] . Recent studies have found that the biological function of COX-2 can enhance the angiogenesis of subunit fibroblast growth factor and VEGF by stimulating the mitosis of human endothelial cells [18] .…”

Section: Resultsmentioning

confidence: 99%

Expression of ID2 and Cyclooxygenase 2 Genes in Endometrial Tissues and Their Clinical Significance in the Pathogenesis of Endometrial Polyps

Wu¹,

Guo²,

Wang³

et al. 2021

ijps

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Wu et al.: Expression of ID2 and COX-2 Genes in endometrial tissues of endometriosis patientsTo investigate the expression of Deoxyribonucleic acid binding inhibitor 2 and Cyclooxygenase 2 genes in endometrial polyps patient's endometrial tissues and analyze their clinical significance is the main objective. 38 patients with endometrial polyps who were treated at the minimally invasive gynecologic and reproductive surgery department of our hospital from October 2020 to December 2020 were selected as the test group, and their polyps and the endometrial tissue around the polyps were taken. 36 cases of women who had undergone intrauterine device placement surgery at the same time were scraped from the endometrium before intrauterine device placement. The messenger ribonucleic acid expression and protein levels of deoxyribonucleic acid binding inhibitor 2 and cyclooxygenase 2 in endometrial tissues were detected by quantitative reverse transcription polymerase chain reaction and western blot. In addition, enzymelinked immunosorbent assay was used to detect the levels of vascular endothelial growth factor, tumor necrosis factor-alpha, interleukin 1 beta and cancer antigen 125 and to analyze their relationship with the expression of Deoxyribonucleic acid binding inhibitor 2 and cyclooxygenase 2 in endometrial tissues of endometrial polyp's patients. The results showed that the expression of Deoxyribonucleic acid binding inhibitor 2 and cyclooxygenase 2 messenger ribonucleic acid and protein levels in endometrial tissues were significantly higher in the experimental group compared with the control group, and the difference was statistically significant. Deoxyribonucleic acid binding inhibitor 2 was positively correlated with vascular endothelial growth factor, tumor necrosis factor alpha, interleukin 1 beta and cancer antigen 125 (p<0.05), while cyclooxygenase 2 was positively correlated with interleukin 1 beta and cancer antigen 125 in the endometrial tissues of patients in the test group. The sensitivity of Deoxyribonucleic acid binding inhibitor 2 was 87.32 %, specificity was 64.88 % and cut-off value was 1.68; the sensitivity of cyclooxygenase 2 was 93.15 %, specificity was 84.33 % and cut-off value was 2.03. Deoxyribonucleic acid binding inhibitor 2 and cyclooxygenase 2 in endometrial tissues has a high predictive value for the clinical diagnosis of endometrial polyps. Expression is closely related to the development of endometrial polyps, and both may be candidate specific target genes for endometrial polyps, and both may be used as markers for the clinical diagnosis of endometrial polyps.

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TargetingID2expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells

Cited by 8 publications

References 26 publications

BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling

BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines

Expression of ID2 and Cyclooxygenase 2 Genes in Endometrial Tissues and Their Clinical Significance in the Pathogenesis of Endometrial Polyps

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