The expression and role of Lysyl oxidase (<scp>LOX</scp>) in dentinogenesis

Tjäderhane, Leo; Vered, Marilena; Pääkkönen, Virve; Peteri, A.; Mäki, Joni M.; Myllyharju, Johanna; Dayan, Dan; Salo, Tuula

doi:10.1111/iej.12031

Cited by 3 publications

(2 citation statements)

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“…During embryogenesis and organ development, LOXs promote infrastructural integration, in addition to facilitating the proper cell stiffness and rigidity required for organogenesis and subsequent morphological maintenance (17,(20)(21)(22)(23). That is, the cells can be secured and maintained properly in the organic mesh and are able to maintain their functional polarity (12).…”

Section: Roles Of Members Of the Lox Family In Organ Developmentmentioning

confidence: 99%

“…The development of teeth has been found to involve ECM condensation and odontogenic stabilization (36), of which both processes can be observed through densely packed collagen fibers and orderly polarized picrosirius red staining. Through investigating odontogenesis, Tjaderhane et al (22) identified no significant differences among the teeth of LOX -/-, LOX +/and wild-type mice under the light microscope; however, following histochemical examination, the teeth of the LOX -/and LOX +/mice were observed to be thinner and unpolarized, which indicated that these effects may be due to the dysregulation of LOX. Kim et al (37) demonstrated that both LOX and LOXLs were essential for organizing periodontal ECM fibrogenesis and promoting the differentiation of dental pulp cells from odontoblasts.…”

Section: Roles Of Members Of the Lox Family In Organ Developmentmentioning

confidence: 99%

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Role of the lysyl oxidase family in organ development (Review)

Wei

Gao

et al. 2020

Exp Ther Med

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Lysyl oxidase proteins (LOXs) are amine oxidases, which are mainly located in smooth muscle cells and fibroblasts and serve an important role in the formation of the extracellular matrix (ECM) in a copper-dependent manner. Owing to the ability of LOX proteins to modulate crosslinking between collagens and to promote the deposition of other fibers, they serve crucially in organogenesis and the subsequent organ development, as well as disease initiation and progression. In addition, ECM formation significantly influences organ morphological formation in both cancer-and non-tumor-related diseases, in addition to cellular epigenetic transformation and migration, under the influence of LOXs. A number of different signaling pathways regulate the LOXs expression and their enzymatic activation. The tissue remodeling and transformation process shares some resemblance between oncogenesis and embryogenesis. Additionally the roles that LOXs serve appeared to be stressed during oncogenesis and tumor metastasis. It has also been indicated LOXs have a noteworthy role in non-tumor diseases. Nonetheless, the role of LOXs in systemic or local organ development and disease control remains unknown. In the present study, the essential roles that LOXs play in embryogenesis were unveiled partially, whereas the role of LOXs in organ or systematic development requires further investigations. The present review aimed to discuss the roles of members of the LOX family in the context of the remodeling of organogenesis and organ development. In addition, the consequences of the malfunction of these proteins related to the development of abnormalities and resulting diseases is discussed. Contents 1. Introduction 2. Roles of members of the LOX family in organ development 3. Signaling pathways involved in the modulation of LOX during tissue development 4. Conclusion Andrology Laboratory and

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