Mechano growth factor-C24E, a potential promoting biochemical factor for ligament tissue engineering

Song, Yang; Yu, Cui; Wang, Chunli; Ma, Xingshuang; Xu, Kang; Zhong, Juila Li; Lv, Yonggang; Sung, K.L. Paul; Yang, Li

doi:10.1016/j.bej.2015.09.023

Cited by 6 publications

(3 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mechano GF-C24E (MGF-C24E) is one of the products of IGF-1 splicing and has been shown to exhibit significant response to mechanical stress. Some of the effects that have been reported through use of MGF-C24E have been increased satellite cell production, increased muscle progenitor cells, and enhanced migratory patterns to assist tendon recovery and oxidative stress reduction (Mooren & Volker, 2005;Song et al, 2016). The reduction in oxidative stress in stretching to the new tendon-joint tunnel can result in less overall stress placed on the joint and increased compliance.…”

Section: Mechano Gf-c24ementioning

confidence: 99%

Biochemical and Structural Alterations in Skeletal Muscle Following ACL Injury: A Narrative Review

Reyes

Willoughby

2020

IJKSS

View full text Add to dashboard Cite

Background: Anterior cruciate ligament (ACL) injuries are some of the most common knee injuries that occur in the US, accounting for around 200,000 documented cases per year. Varying levels of severity can determine whether surgery is required or if physical therapy will suffice. One of the most common complications for patients is that there is significant atrophy of the impacted limb. Yet, there has not been definitive proof explaining this mechanism. Objective: The primary goal for this review was to examine some of the biochemical differences that tend to occur within and surrounding an ACL injury and the mechanisms involved in skeletal muscle atrophy and regenerative capabilities. Outcome: Multiple studies have found a connection between time spent inactive from the injury and the percentage of retained muscle after exercising again. Among decreases in muscle mass and muscle volume changes, analyses have also revealed alterations in alpha-2 macroglobulin, myostatin, heat shock protein-72, mechano GF-C24E, synovial fluid, and histochemical alterations in collagen and cartilaginous states which all seem to be primary factors in regulating effectiveness and speed of recovery from ACL injury. Conclusion: the influx of various cytokines as a response to the initial injury in relation to inflammation change the chemical and physical environment of the knee, making recovery significantly more difficult and time-consuming. Timing of injury, surgery, and re-initiation of movement after surgery are very important factors that can minimize overall damage and reduce recovery time.

show abstract

Section: Mechano Gf-c24ementioning

confidence: 99%

Biochemical and Structural Alterations in Skeletal Muscle Following ACL Injury: A Narrative Review

Reyes

Willoughby

2020

IJKSS

View full text Add to dashboard Cite

show abstract

“…Zhang et al reported that MGF can be used for tendon injury repair by promoting tenocyte migration. In our previous studies, we demonstrated that MGF acts as a catalyst enhancing TGF‐β3‐induced cartilage regeneration (Q. Luo, Wu, Zhang, & Song, ), promotes extracellular matrix (ECM) synthesis for the repair of ligament tears (Song et al, ), and possesses anti‐inflammatory potential in OA fibroblast‐like synoviocytes (H. Li et al, ). However, to the best of the authors' knowledge, studies on the role of MGF in OA treatment are not available, and the potential capability and mechanism of MGF in the repair of cartilage or the prevention of cartilage degeneration are still unknown.…”

Section: Introductionmentioning

confidence: 99%

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis

Song

et al. 2017

J Tissue Eng Regen Med

Self Cite

View full text Add to dashboard Cite

Previous studies have attached more importance to growth factors in treating cartilage degeneration and osteoarthritis (OA). Here, the capability of mechano growth factor-C24E (MGF) to prevent osteoarthritic cartilage degeneration was evaluated in vitro and in vivo. Using in vitro cultured human OA chondrocytes treated with 10-60-ng/ml MGF for 12 hr, we detected the cell proliferation, migration, and anabolism of OA chondrocytes. The unfolded protein response and the protein characteristic of OA pathology, such as transforming growth factor β, SMAD family member 3, and hypoxia-inducible factor 2α of OA chondrocytes, were also detected by western blotting. Furthermore, protein kinase RNA-like endoplasmic reticulum kinase was knocked down via small interfering RNA to illuminate the potential mechanism of MGF's treatment of OA. In a rabbit knee joint OA model, cartilage degeneration was inhibited after 2 weeks of treatment with 0.1-10-μg/ml MGF. This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration, and matrix synthesis of the chondrocytes. The results also demonstrate that the degeneration of OA cartilage can be delayed by MGF treatment partially via unfolded protein response regulated by protein kinase RNA-like endoplasmic reticulum kinase and suggest a potential therapeutic application of MGF for OA treatment.

show abstract

“…OPLL can cause spinal canal stenosis and spinal cord compression, leading to sensory and motor dysfunction. The pathogenesis of OPLL is still not clear, the occurrence and development of OPLL are pathologic processes of multiple factors acting together including genetic factors, [1][2][3] endocrine factors, [4][5][6] mechanical stress change stimulation and biomechanical factors. 6,7 Currently, there are no effective treatments to prevent or inhibit the occurrence and development of ossification at present, and surgical treatment for spinal cord decompression is recommended for patients' clinical symptoms caused by compression of the neural structures of the cervical spine due to OPLL.…”

mentioning

confidence: 99%

Comparative Effectiveness and Functional Outcome of C2 Dome-like Expansive Versus C2 Expansive Open-door Laminoplasty for Upper Cervical Ossification of the Posterior Longitudinal Ligament

Zhang

et al. 2021

Spine

View full text Add to dashboard Cite

show abstract

Mechano growth factor-C24E, a potential promoting biochemical factor for ligament tissue engineering

Cited by 6 publications

References 71 publications

Biochemical and Structural Alterations in Skeletal Muscle Following ACL Injury: A Narrative Review

Biochemical and Structural Alterations in Skeletal Muscle Following ACL Injury: A Narrative Review

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis

Comparative Effectiveness and Functional Outcome of C2 Dome-like Expansive Versus C2 Expansive Open-door Laminoplasty for Upper Cervical Ossification of the Posterior Longitudinal Ligament

Contact Info

Product

Resources

About