The expression and role of TRPV2 in esophageal squamous cell carcinoma

PURPOSE: We determined if the immunohistochemical expression pattern of transient receptor potential vanilloid (TRPV) family members and TRP ankyrin 1 (TRPA1) differs among a healthy conjunctival epithelium and diseased epithelia. MATERIALS AND METHODS: Subjects include a normal conjunctival epithelium, pterygium epithelium, epithelial dysplasia or carcinoma in situ . RESULTS: TRPV1, TRPV4 or TRPA1 was detected in both the cytoplasm and nuclei, or in either the nuclei or cytoplasm, of these different epithelial layers, respectively. There was no difference in the expression pattern of these three TRP isoforms. On the other hand, the expression patterns of TRPV2 and TRPV3 differed dramatically among these different subjects. TRPV2 was observed in the basal layer epithelium of a normal conjunctiva and pterygium. Its pattern was scattered in this region, although TRPV2 was absent throughout most of the dysplastic epithelium. TRPV2 was detected only in some of the suprabasal epithelial cells of a carcinoma in situ . TRPV3 was faintly detected in the cytoplasm of all the cell layers and also in the nuclei of some of the basal cells in a normal conjunctiva and in the pterygia epithelium, while in situ it was uniformly expressed in all of the dysplasia and carcinoma nuclei in all epithelial cell layers. CONCLUSION: These results suggest that TRPV2 and TRPV3 expression pattern analysis might be potential diagnostic markers of ocular surface epithelial disorders.

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“…[ 10 19 ] It was suggested that the upregulation of both TRPV2 and TRPV3 might be related to the degree of epithelial tumor malignancy. [ 20 21 ]…”

Section: Discussionmentioning

confidence: 99%

Alteration of expression pattern of transient receptor potential vanilloid 2 and transient receptor potential vanilloid 3 in ocular surface neoplasm

Izutani-Kitano

Okada

Ichikawa

et al. 2020

Taiwan J Ophthalmol

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“…The knockdown of TRPV2 in ESCC cells decreased proliferation, cell cycle progression, and the ability to invade and migrate. Moreover, the authors found downregulated WNT/β-catenin or basal cell carcinoma signaling-related genes [74]. TRPV1 and TRPV4 were both found to be expressed on mRNA and protein level in non-tumorous esophageal squamous cells and overexpressed in ESCC cells.…”

Section: Trpv2mentioning

confidence: 93%

“…Protein (IHC) 62 ESCC tissue samples Analysis of TRPV2 expression (low/high); worse overall survival and 5 year survival of patients with high TRPV2 protein expression [74] TRPC6 mRNA and protein expression levels are increased in human ESCC tissues compared to normal esophageal tissues. Furthermore, the inhibition of TRPC6 in ESCC cells led to decreased Ca 2+ signaling and cell cycle arrest via Cdk1.…”

Section: Trpv2mentioning

confidence: 99%

TRP Channels in Digestive Tract Cancers

Stokłosa

Borgström

Kappel

et al. 2020

IJMS

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Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently, many biomedical studies focus on the role of ion channels, in particular transient receptor potential (TRP) channels, in cancer pathophysiology. TRP channels show mostly non-selective permeability to monovalent and divalent cations. TRP channels are often dysregulated in digestive tract cancers, which can result in alterations of cancer hallmark functions, such as enhanced proliferation, migration, invasion and the inability to induce apoptosis. Therefore, TRP channels could serve as potential diagnostic biomarkers. Moreover, TRP channels are mostly expressed on the cell surface and ion channel targeting drugs do not need to enter the cell, making them attractive candidate drug targets. In this review, we summarize the current knowledge about TRP channels in connection to digestive tract cancers (oral cancer, esophageal cancer, liver cancer, pancreatic cancer, gastric cancer and colorectal cancer) and give an outlook on the potential of TRP channels as cancer biomarkers or therapeutic targets.

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“…Increased TRPV2 expression predicted higher disease-free survival is a subset of patients with triple-negative breast cancer [ 114 ]. TRPV2 overexpression is also present in patients with advanced esophageal squamous cell carcinoma associated with metastatic disease [ 104 ]. In prostatic adenocarcinoma, TRPV2 overexpression predicts the castration-resistant phenotype.…”

Section: Trp Channels As Potential Diagnostic and Prognostic Toolsmentioning

confidence: 99%

Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials

Kiss

Pohóczky

Szállaśi

et al. 2020

IJMS

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Head-and-neck squamous cell carcinomas (HNSCC) remain a leading cause of cancer morbidity and mortality worldwide. This is a largely preventable disease with smoking, alcohol abuse, and human papilloma virus (HPV) being the main risk factors. Yet, many patients are diagnosed with advanced disease, and no survival improvement has been seen for oral SCC in the past decade. Clearly, new diagnostic and prognostic markers are needed for early diagnosis and to guide therapy. Gene expression studies implied the involvement of transient receptor potential (TRP) channels in the pathogenesis of HNSCC. TRPs are expressed in normal epithelium where they play a key role in proliferation and differentiation. There is increasing evidence that the expression of TRP channels may change in HNSCC with important implications for diagnosis, prognosis, and therapy. In this review, we propose that TRP channel expression may afford a novel opportunity for early diagnosis of HNSCC and targeted molecular treatment.

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The expression and role of TRPV2 in esophageal squamous cell carcinoma

Cited by 38 publications

References 34 publications

Alteration of expression pattern of transient receptor potential vanilloid 2 and transient receptor potential vanilloid 3 in ocular surface neoplasm

Alteration of expression pattern of transient receptor potential vanilloid 2 and transient receptor potential vanilloid 3 in ocular surface neoplasm

TRP Channels in Digestive Tract Cancers

Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials

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