The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm

Li, C.; Zhu, Xianchun; Wang, C.; Liu, Zhuo; Li, W.; Lu, Ciyong; Zhou, Xu

doi:10.1016/j.theriogenology.2011.09.003

Cited by 22 publications

(24 citation statements)

References 21 publications

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“…Both the mRNAs encoding BDNF, NT4 and TRKB and the corresponding proteins have been detected in ejaculated bull sperm. The BDNF protein was found in the head, neck and tail of the sperm cells, whereas NT4 was localized in the equatorial segment and the mid-section of the spermatozoa and TRKB was strongly localized in the acrosome (Li et al 2012, Wang et al 2013.…”

Section: The Roles Of Neurotrophins In Testicular Developmentmentioning

confidence: 99%

“…Interestingly, BDNF can increase the secretion of insulin and leptin in ejaculated sperm, and treatment with exogenous BDNF for 2 h affects sperm apoptosis and viability. Moreover, both BDNF and NT4 have been shown to regulate mitochondrial activity in sperm (Li et al 2012, Wang et al 2013. A clinical study has shown that the levels of BDNF mRNA in the sperm and BDNF protein in the seminal plasma of a group of oligoasthenozoospermic men were lower than those in a fertile group, indicating that the decreases in the abundance of BDNF and its mRNA transcript may be associated with pathogenesis in some types of male infertility (Zheng et al 2011).…”

Section: The Roles Of Neurotrophins In Testicular Developmentmentioning

confidence: 99%

“…A clinical study has shown that the levels of BDNF mRNA in the sperm and BDNF protein in the seminal plasma of a group of oligoasthenozoospermic men were lower than those in a fertile group, indicating that the decreases in the abundance of BDNF and its mRNA transcript may be associated with pathogenesis in some types of male infertility (Zheng et al 2011). It is postulated that the BDNF/NT4-TRKB system may promote the survival of testicular cells (Moon et al 2005, Li et al 2012, Wang et al 2013). …”

Section: The Roles Of Neurotrophins In Testicular Developmentmentioning

confidence: 99%

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The potential roles of neurotrophins in male reproduction

Li¹,

Zhou²

2013

Reproduction

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Neurotrophins are a family of polypeptide growth factors that are required for the proliferation, differentiation, survival, and death of neuronal cells. A growing body of evidence suggests that they may have broader physiological roles in various non-neuronal tissues. The testicles are complex non-neuronal organs in which diverse cell types interact to achieve correct spermatogenesis. Both neurotrophins and their receptors have been detected in various cell types from mammalian testes, suggesting that neurotrophins may regulate or mediate intercellular communication within this organ. This review summarizes the existing data on the cellular distribution and possible biological roles of neurotrophins in the testes. The data reported in the literature indicate that neurotrophins affect somatic cell growth and spermatogenesis and imply that they play a role in regulating testicular development and male reproduction.Reproduction (2013) 145 R89-R95

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Section: The Roles Of Neurotrophins In Testicular Developmentmentioning

confidence: 99%

Section: The Roles Of Neurotrophins In Testicular Developmentmentioning

confidence: 99%

Section: The Roles Of Neurotrophins In Testicular Developmentmentioning

confidence: 99%

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The potential roles of neurotrophins in male reproduction

Li¹,

Zhou²

2013

Reproduction

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“…For determination of serum leptin, 4 heifers from each group were randomly selected for sampling at 6 predefi ned time points: at the beginning of the dietary treatments, 7 d before the fi rst leptin injection, during the leptin treatment (7, 14, and 28 d after commencing leptin injection), and 11 d after the last leptin injection. Serum leptin was determined by ELISA, specifi c for bovine leptin (Cusabio Biotech Co., Ltd., Hubei, PR China), according to the manufacturer's protocol (Li et al, 2012). The concentration of leptin in samples was determined using a 4 parameter logistic curve fi tting algorithm option in the Master Plex QT3.0 quantifi cation software (MiraiBio Inc., Alameda, CA).…”

Section: Hormonal Treatment and Reproductive Evaluationmentioning

confidence: 99%

Effect of chronic infusion of leptin and nutrition on sexual maturation of zebu heifers1

Carvalho

Diniz-Magalhães

Pereira

et al. 2013

Journal of Animal Science

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ABSTRACT:The amount of fat in the carcass has been proposed as a regulator of initiation of puberty in cattle. To test if changes in energy intake and in circulating leptin concentration are each capable of altering age, BW, and body composition at puberty, 36 prepubertal Nellore heifers, 18 to 20 mo old, 275.8 ± 17.2kg BW, and BCS of 5 ± 0.5 (1 to 9 scale), were randomly assigned to each of 3 treatments (n = 12): High (high energy diet), Low (low energy diet), and LL [low energy diet + ovine leptin (oLeptin)]. Diets were formulated to promote BW gain of 0.4 kg/d (groups Low and LL) or 1.2 kg/d (High group). After 14 d of adjustment to diet, heifers in LL group received subcutaneous injections of oLeptin at 4.8 μg/kg BW twice a day for 56 d. Groups High and Low received similar injections of 2 mL saline solution. Age at puberty was considered to be the age on fi rst detection of a corpus luteum, confi rmed by plasma concentrations of progesterone of >1 ng/mL. Heifers were slaughtered on the second day after fi rst corpus luteum detection. Expression of leptin gene was quantifi ed by real-time PCR using ribosomal protein-L19 (RP-L19) as a control gene. Leptin administration increased

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“…BDNF has been detected in adult Legdig and Stertoli cells using immunocytochemistry, while its high affinity receptor, TrkB has been found in spermatogonia [9], indicating that BDNF could have a potential role in testis devel opment. In our recent studies, BDNF and TrkB tran scripts and proteins were detected in human and bovine mature sperm [10,11]. In bovine, BDNF could regulate the secretion of insulin and leptin, and affect 1 The article is published in the original.…”

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confidence: 99%

No association between the G196A and C270T polymorphism of the brain-derived neurotrophic factor gene and male infertility

Zheng

Sun

et al. 2012

Russ J Genet

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Brain derived neurotrophic factor (BDNF) plays important roles in neuronal development and reproductive action. Abnormal expression of BDNF gene has been detected in human sperm and seminal serum. In the present study, we investigated the possible association of G196A and C270T polymorphism of BDNF gene with male infertility. The genotypes of the G196A and C270T polymorphisms were in HardyWeinberg equilibrium both in fertile and infertile group. The genotype distribution frequencies were similar between infertile and fertile group. The results showed that the G196A and C270T polymorphism of the BDNF gene is unrelated to the male infertility, at least in a Chinese population.

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The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm

Cited by 22 publications

References 21 publications

The potential roles of neurotrophins in male reproduction

The potential roles of neurotrophins in male reproduction

Effect of chronic infusion of leptin and nutrition on sexual maturation of zebu heifers1

No association between the G196A and C270T polymorphism of the brain-derived neurotrophic factor gene and male infertility

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