The exposure‐time‐response relationship between occupational asbestos exposure and lung cancer in two German case‐control studies*

Abstract

In contrast to previous indications, the risk of lung cancer increases soon after asbestos exposure, with its maximum effect from 10 to 15 years after the exposure was received.

Predictors of lung cancer among former asbestos-exposed workers

“…The study has revealed, that the risk of lung cancer increases soon after starting exposure to asbestos with the maximum effect after 10-15 years from the last exposure [18]. The results of our study showed that the risk of lung cancer continued to increase until 30 years after cessation of exposure and started to decline many years after the last exposure.…”

The Mesothelioma epidemic in Western Europe: an update

“…Thus, to explain the development of the mesothelioma epidemic, other factors need to be invoked, such as the type of asbestos mainly used in different countries over time (Hodgson and Darnton, 2000), duration of exposure and years since last exposure (Hauptmann et al, 2002). It does, however, appear that the number of asbestos-related mesothelioma deaths during 1995 -2029 in Europe is likely to be lower than the 250 000 previously estimated on data available up to 1994.…”

Occupation and Lung Cancer Mortality in a Nationally Representative U.S. Cohort: The National Health Interview Survey (NHIS)

“…50 The influence of occupation and lung cancer mortality risk varies considerably as a function of the duration and intensity of carcinogen exposure. 51,52 Occupational exposure assessment using detailed interviews enables the construction of a job-exposure matrix. This approach generally leads to stronger associations between highrisk occupations and lung cancer risk than when job title is used as a surrogate for job exposure as was the case in the present study.…”