The Expected Beneficial Effects of Watermelon Juice against Damage Induced by Gamma Radiation in the Testis of Rats

Abstract

Background: The present study was designed to evaluate the expected beneficial effect of watermelon juice (WJ) on γ-radiation induced inflammation and testes tissue damage in rats.Methods: The values for total phenolic contents, antioxidant activity and 2,2-diphenyl-1-picrylhydrazyl for WJ were detected. 28 Male rats were randomly divided into 4 groups (seven rats in each group) as follows; Control group, WJ group (received WJ by oral gavage 100 mg/kg B.Wt. / day/ 6 weeks), group 3 and 4: Irradiated group only (6Gy; the 1st week) and irradiated and WJ group, respectively. At the end of the experiment, blood and tissue samples were collected for biochemical analysis and histopathological examination.Result: It has been found that γ-irradiation led to testicular oxidative stress accompanied by hormonal disturbance (elevation of follicle stimulating hormone (FSH) and reduction of testosterone and luteinizing hormone (LH) levels) and elevation of inflammatory factors (serum tumor necrotic factor-alpha (TNF-α), interleukin-6 (IL-6) ). Rats received WJ after exposure to γ-rays showed significantly less severe damage and remarkable improvement in all of the measured parameters and also restored the histological changes in the testis when compared to irradiated rats.

Annona Muricata L. extract restores renal function, oxidative stress, immunohistochemical structure, and gene expression of TNF-α, IL-β1, and CYP2E1 in the kidney of DMBA-intoxicated rats

“…These compounds are used to treat a variety of illnesses, including renal impairment (Arthur et al, 2011;Hassan et al, 2019). The graviola extract's phytochemical analysis revealed many valuable secondary metabolites, such as tannins and steroids (El-Shahat et al, 2021). In numerous studies, GRV has been shown to protect against oxidative stress, enhance antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase, and glutathione, improve blood lipid levels, decrease LDL, total cholesterol, and triglycerides, increase HDL, and exert a wide range of beneficial effects, including anticonvulsive, anticancer, anti-arthritic, anti-malarial, hepatoprotective, and antidiabetic ones (Rady et al, 2018;Shukry et al, 2020;El-Shahat et al, 2021).…”

“…The graviola extract's phytochemical analysis revealed many valuable secondary metabolites, such as tannins and steroids (El-Shahat et al, 2021). In numerous studies, GRV has been shown to protect against oxidative stress, enhance antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase, and glutathione, improve blood lipid levels, decrease LDL, total cholesterol, and triglycerides, increase HDL, and exert a wide range of beneficial effects, including anticonvulsive, anticancer, anti-arthritic, anti-malarial, hepatoprotective, and antidiabetic ones (Rady et al, 2018;Shukry et al, 2020;El-Shahat et al, 2021). Recent researches support the usefulness of GRV in the prevention of cancer and degenerative diseases, including renal disease, due to the presence of potent antioxidants such as polyphenols and flavonoids, which provide defense against the accumulation of reactive oxygen species (ROS) (Alam et al, 2014).…”