Examined is the experience of loneliness as it relates to selected health conditions and selected economic conditions. The effects on loneliness of age, gender, marital status, number of sons, number of daughters, number of male friends, and number of female friends also were examined and controlled. Results are based on a sample from the Senior Citizens Nutrition and Activities Program in Hillsborough County, Florida. An analysis of covariance showed that greater loneliness was expressed by those older persons who were male, had fewer female friends, and had fewer male friends. Among the main effects, poorer self-rated health, less adequate self-rated economic condition, and being in poverty were related to greater loneliness. The interactions between the main effects variable were unrelated to loneliness. The research sheds new light on the influence on loneliness of older persons' health and economic condition, and of selected demographic and interpersonal relationship variables. This article examines the association between the expression of loneliness and objective and subjective indicators of health and economic condition of older persons. The general hypothesis to be investigated is that poorer health, and poorer economic condition, both objectively and subjectively determined, are related to a greater indication of loneliness. To examine this issue more concisely, the effects of other relevant variables are examined and AUTHORS' NOTE: We would like to thank the participants and the personnel of the Senior Citizens Nutrition and Activities Program in Hillsborough County, Florida for their cooperation and help. Special thanks are given to Gil Machin and Janet Georgas for their ongoing support.