The Examining of Isolated Tannins and their Astringent Effect

Grujić-Vasić, J.; Bosnić, T.; Jovanović, Milica

doi:10.1055/s-2007-969352

Cited by 5 publications

(2 citation statements)

References 1 publication

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“…Preliminary phytochemical analysis revealed that the leaf extract of S. jollyanum contains alkaloids, tannins, saponins, flavonoids and cardiac glycosides. These plant phytochemicals play important preventive activities mainly as anticancer, antidiarrheals, antioxidant, anti-parasitic, antiviral, antidiabetic, antibacterial, anti-inflammatory, antimicrobial, anti-aging, antidepressant, and wound healing (Athanasiadou et al, 2001;Grujić-Vasić et al, 1986;Kang et al, 2011;Bahramsoltani et al, 2014). It is also reported that leaves containing these phytochemicals help in hypocholesterolemic, immunostimulant, and anticarcinogenic properties and are believed to lower the risk of cancer and other chronic diseases in humans (Ros, 2000;Hostanska et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Phytochemicals, acute toxicity and in-vitro antioxidant activity of ethanol extract of Sphenocentrum jollyanum leaves

Uka¹,

Etim²,

Effiong³

et al. 2020

J. Drugs Pharm. Sci.

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Medicinal plants possess strong antioxidants that help to scavenge and protect the human health against several diseases caused by free radicals. This study was carried out to evaluate the phytochemical constituents, acute toxicity and antioxidant activity of the ethanol extract of Sphenocentrum jollyanum leaves in order to validate the medicinal potential of this herb. The antioxidant activity was evaluated using different in vitro models such as total phenolic, flavonoid content, DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP) and Iron chelating activity. Phytochemical constituents included alkaloids, saponins, tannins, flavonoids and cardiac glycosides while total phenolic, flavonoid and gallic acid equivalent were 31.49, 29.98 and 1215.80 mg/mL respectively. The acute toxicity revealed that the oral lethal dose of the ethanol extract of S. jollyanum leaves is non-toxic and safe for consumption. The leaf extract of S. jollyanum exhibited scavenging activity with IC50 of 164.214, 72.410 and 167.202 mg/mL for DPPH, FRAP and Iron chelating activity respectively. The results obtained from this study reveal that the extract is rich in antioxidant components with several mechanisms of eliciting antioxidant actions which provide a scientific basis for its use in traditional system of medicine.

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Section: Discussionmentioning

confidence: 99%

Phytochemicals, acute toxicity and in-vitro antioxidant activity of ethanol extract of Sphenocentrum jollyanum leaves

Uka¹,

Etim²,

Effiong³

et al. 2020

J. Drugs Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…20 Gelatin tannate is commonly employed as an intestinal astringent and present in the market with various names, such as tanagel, gelenterum, or tasectan. 21 This complex passes through the stomach unaltered to dissolve into gelatine and tannic acid once in the gut, where it may exert its action by restoring the physiological function of the intestine. Furthermore, the well-known astringent properties of tannins allow the precipitation of proinflammatory mucoproteins from the intestinal mucus and their elimination through the faeces.…”

Section: Introductionmentioning

confidence: 99%