The Evolving Role of 18F-FDG PET/CT in Diagnosis and Prognosis Prediction in Progressive Prostate Cancer

Shen, Kai; Liu, Bo; Zhou, Xiang; Ji, Yiyi; Chen, Lei; Wang, Qi; Xue, Wei

doi:10.3389/fonc.2021.683793

Cited by 31 publications

(24 citation statements)

References 76 publications

(158 reference statements)

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“…Various PET tracers are now available for the imaging of prostate cancer and neuroendocrine differentiation. A recent clinical case series demonstrated excellent detection rates for the metastases (95%), specifically the visceral and nodal metastases in NEPCs by using FDG-PET [ 51 , 52 ]. The positron-emitting somatostatin analogs, which bind to somatostatin receptors (SSRTs) with high affinity, 68 Ga-DOTATATE or 68 Ga DOTANOC are also suitable and found to be as highly accurate as the PET/CT radiotracers, for the display of somatostatin-expressing NETs [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…FDG PET findings can also serve as prognostic marker in cases of metastatic NEPC. When stratified by the median survival from NEPC diagnosis, patients who survived <2.2 versus ≥2.2 years, had more PET avid bone and soft tissue lesions and higher average SUVmax of bone and soft tissue lesions [ 51 , 52 ]. Some low-grade neuroendocrine tumors may not be intensely FDG-avid and rather may be more intensely avid on 68 Gallium DOTATATE PET, as shown with gastroenteropancreatic neuroendocrine neoplasms [ 53 ].…”

Section: Pathologic Classification and Genetic Alterationsmentioning

confidence: 99%

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Imaging of Neuroendocrine Prostatic Carcinoma

Taher

Jensen

Yedururi

et al. 2021

Cancers

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Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that typically has a high metastatic potential and poor prognosis in comparison to the adenocarcinoma subtype. Although it can arise de novo, NEPC much more commonly occurs as a mechanism of treatment resistance during therapy for conventional prostatic adenocarcinoma, the latter is also termed as castration-resistant prostate cancer (CRPC). The incidence of NEPC increases after hormonal therapy and they represent a challenge, both in the radiological and pathological diagnosis, as well as in the clinical management. This article provides a comprehensive imaging review of prostatic neuroendocrine tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Pathologic Classification and Genetic Alterationsmentioning

confidence: 99%

Imaging of Neuroendocrine Prostatic Carcinoma

Taher

Jensen

Yedururi

et al. 2021

Cancers

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“…On the other hand, the evolution of non-invasive imaging methods has permitted the study of cancer metabolism (i.e., metabolomics studies) or structure. Firstly, we can cite fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging which is used in routine to detect increased glucose uptake by advanced/aggressive tumors such as breast, colorectal, and thyroid cancer (DTC, MTC, and ATC) [ 144 , 145 , 146 ]. In addition to FDG, a wide range of radiolabeled carbohydrates, amino acids, and fatty acids detected by PET are studied to try and take advantage of the high metabolic rate of tumors, creating a bridge between cell biochemistry and in vivo diagnostics [ 147 , 148 ].…”

Section: Conceptual Diagnostic and Therapeutic Implications Of The Dynamic Heterogeneity Of Cancermentioning

confidence: 99%

Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications

Jacquemin

Antoine

Dom

et al. 2022

Cancers

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Though heterogeneity of cancers is recognized and has been much discussed in recent years, the concept often remains overlooked in different routine examinations. Indeed, in clinical or biological articles, reviews, and textbooks, cancers and cancer cells are generally presented as evolving distinct entities rather than as an independent heterogeneous cooperative cell population with its self-oriented biology. There are, therefore, conceptual gaps which can mislead the interpretations/diagnostic and therapeutic approaches. In this short review, we wish to summarize and discuss various aspects of this dynamic evolving heterogeneity and its biological, pathological, clinical, diagnostic, and therapeutic implications, using thyroid carcinoma as an illustrative example.

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“…18 Fluorinated 2-deoxy glucose ( 18 F-FDG) is one of the most extensively used PET tracers. The design of 18 F-FDG is for detecting the higher expression of glucose transporters in cancer cells [9]. The 2-deoxyglucose (2-DG) is excessively taken up by the tumor as upregulated glucose transporters are phosphorylated in the glycolysis pathway, while the normal tissue has an insignificant uptake of 2-DG.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial Probes for Nuclear Imaging

et al. 2022

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Nuclear imaging is a powerful non-invasive imaging technique that is rapidly developing in medical theranostics. Nuclear imaging requires radiolabeling isotopes for non-invasive imaging through the radioactive decay emission of the radionuclide. Nuclear imaging probes, commonly known as radiotracers, are radioisotope-labeled small molecules. Nanomaterials have shown potential as nuclear imaging probes for theranostic applications. By modifying the surface of nanomaterials, multifunctional radio-labeled nanomaterials can be obtained for in vivo biodistribution and targeting in initial animal imaging studies. Various surface modification strategies have been developed, and targeting moieties have been attached to the nanomaterials to render biocompatibility and enable specific targeting. Through integration of complementary imaging probes to a single nanoparticulate, multimodal molecular imaging can be performed as images with high sensitivity, resolution, and specificity. In this review, nanomaterial nuclear imaging probes including inorganic nanomaterials such as quantum dots (QDs), organic nanomaterials such as liposomes, and exosomes are summarized. These new developments in nanomaterials are expected to introduce a paradigm shift in nuclear imaging, thereby creating new opportunities for theranostic medical imaging tools.

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The Evolving Role of 18F-FDG PET/CT in Diagnosis and Prognosis Prediction in Progressive Prostate Cancer

Cited by 31 publications

References 76 publications

Imaging of Neuroendocrine Prostatic Carcinoma

Imaging of Neuroendocrine Prostatic Carcinoma

Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications

Nanomaterial Probes for Nuclear Imaging

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