The evolution of basal septal hypertrophy: From benign and age‐related normal variant to potentially obstructive and symptomatic cardiomyopathy

Pearson, Anthony C.

doi:10.1111/echo.13588

Cited by 15 publications

(15 citation statements)

References 41 publications

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“…Особенностью сверхдолгожителей является позднее развитие возраст-ассоциированных заболеваний, включая ССЗ [10] [13]. Также было показано, что распространенность диастолической дисфункции в разных возрастных группах варьируются и может достигать 50% среди здоровых добровольцев в возрасте 65 лет и старше [14].…”

Section: Discussionunclassified

“…Другим возраст ассоциированным изменением является диастолическая дисфункция ЛЖ, ее встречаемость каждое десятилетие начиная с 65 лет у мужчин удваивается, а у женщин утраивается. В 2008г впервые было описано Дискретное утолщение верхней части межжелудочковой перегородки (DUST -discrete upper septal thickening) [13]. Распространённость данного феномена прямо пропорциональна возрасту и, по данным Фра мин гем ского исследования, среди лиц старше 85 лет достигает 18%.…”

Section: заключениеunclassified

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Cardiovascular system status of long-livers in Moscow: the prevalence of cardiovascular diseases and their risk factors

et al. 2021

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Over the past century, an increase in life expectancy has been observed in Russia and in the world. According to the United Nations, by 2100, the number of centenarians worldwide will reach 25 million. Despite the annual increase in the number of super-centenarians, this age group remains poorly understood.Aim. To estimate the prevalence of cardiovascular diseases (CVD) and the main risk factors among super-centenarians in Moscow.Material and methods. According to the register of long-livers in Moscow, 82 people aged 95 to 105 were included. Participants were examined at home.The history of life and the presence of chronic diseases was collected by participant words. To assess the state of cardiovascular system, an ultrasound of the heart and main arteries was performed.Results. Conventional CVD risk factors were the exception rather than the rule among study participants (smoking — 8 patients (9,8%), alcohol abuse — 4 (4,9%), obesity — 6 (7,3%)). Dyslipidemia was relatively widespread (n=37; 45,1%), however, there were no pronounced abnormalities in the lipid profile: the maximum increase in low-density lipoproteins was 5,6 mmol/L. The most common CVDs among the participants were hypertension (n=64; 78%), coronary artery disease (n=42; 51,2%), and heart failure (n=26; 31,7%); other diseases were much less common. The most common echocardiographic changes were left atrial dilatation (n=38; 74,5%), increased left ventricular mass, thickening of left ventricular posterior wall (n=24; 48%) and interventricular septum (n=51; 100%). Diastolic and systolic heart failure were not widespread among long-livers: 16 (32%) and 2 (3,9%), respectively. Despite a rather large number of atherosclerotic plaques in the common carotid and femoral arteries, the number of hemodynamically significant plaques was low (n=3; 4,6%). An intima-media thickening up to 1,0-1,1 mm was found.Conclusion. Long-livers in Moscow are characterized by a low prevalence of traditional CVD risk factors (with the exception of hypertension) and a fairly high prevalence of atherosclerotic CVDs, which are characterized by a subclinical course.

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Cardiovascular system status of long-livers in Moscow: the prevalence of cardiovascular diseases and their risk factors

et al. 2021

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“…BSH is diagnosed when the diastolic basal ventricular septum thickness is >14 mm and the ratio of diastolic basal to mid-septal thickness is >1.3. [ 5 ] It may mimic as asymmetric septal hypertrophy seen in HOCM. Waller et al showed that the basal portion of the ventricular septum bends towards LV and bulges into the LVOT as a result of the rightward shift of dilated ascending aorta.…”

Section: Discussionmentioning

confidence: 99%

Systolic anterior motion of mitral valve following resection of subaortic membrane and intracardiac repair of tetralogy of fallot

Gourav¹,

Kumar²,

Bhat³

et al. 2020

Ann Card Anaesth

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Systolic anterior motion (SAM) of the mitral valve is commonly observed in patients with hypertrophic obstructive cardiomyopathy and in few patients after mitral valve repair or aortic valve replacement. It may cause significant hemodynamic instability due to left ventricular outflow tract (LVOT) obstruction and resulting mitral regurgitation. Subaortic septal bulge is considered as a one of the risk factor for the development of SAM as it narrows the LVOT. We report a case of tetralogy of fallot with subaortic septal bulge who developed SAM of the anterior mitral leaflet, intraoperatively, after resection of a subaortic membrane.

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“…In early stages of hypertension, some patients demonstrate localized hypertrophy of the basal septum. The significance of this finding is not definitive; however, some studies indicate that it serves as a marker of a more advanced impact of afterload on cardiac function in patients with hypertension [ 2 ]. If a patient presents with localized thickening, there is reasonable concern that they have hypertension influencing the cardiac function and might benefit from more stringent blood pressure control and a detailed follow-up.…”

Section: Introductionmentioning

confidence: 99%

Septal curvature as a robust and reproducible marker for basal septal hypertrophy

Marciniak

Gilbert

Lončarić

et al. 2021

Journal of Hypertension

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Background: Basal septal hypertrophy (BSH) is an asymmetric, localized thickening of the upper interventricular septum and constitutes a marker of an early remodelling in patients with hypertension. This morphological trait has been extensively researched because of its prevalence in hypertension, yet its clinical and prognostic value for individual patients remains undetermined. One of the reasons is the lack of a reliable and reproducible metric to quantify the presence and the extent of BSH. This article proposes the use of the curvature of the left ventricular endocardium as a robust feature for BSH characterization, and as an objective criterion to quantify current subjective ‘visual assessment’ of the presence of sigmoidal septum. The proposed marker, called average septal curvature, is defined as the inverse of the radius adjacent to each point of the endocardial contour along the basal and mid inferoseptal segments of the left ventricle. Method: Robustness and reproducibility were assessed on a cohort of 220 patients, including 161 hypertensive patients (32 with BSH) and 59 healthy controls. Results: The results show that compared with the conventionally used wall thickness metrics, the new marker is more reproducible (relative standard deviation of errors of 7 vs. 13%, and 8 vs. 38% for intra-observer and inter-observer variability, respectively) and better correlates to the functional parameters related to BSH, with main difference (absolute rank correlation 0.417 vs. 0.341) in local deformation changes assessed by longitudinal strain. Conclusion: Average septal curvature is a more precisely defined and reproducible metric than thickness ratios, it can be fully automated, and better infers the functional remodelling related to hypertension.

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The evolution of basal septal hypertrophy: From benign and age‐related normal variant to potentially obstructive and symptomatic cardiomyopathy

Cited by 15 publications

References 41 publications

Cardiovascular system status of long-livers in Moscow: the prevalence of cardiovascular diseases and their risk factors

Cardiovascular system status of long-livers in Moscow: the prevalence of cardiovascular diseases and their risk factors

Systolic anterior motion of mitral valve following resection of subaortic membrane and intracardiac repair of tetralogy of fallot

Septal curvature as a robust and reproducible marker for basal septal hypertrophy

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