The evidence base regarding the experiences of and attitudes to preimplantation genetic diagnosis in prospective parents

Uptake of Preimplantation Genetic Diagnosis in Female BRCA1 and BRCA2 Mutation Carriers

“…The process of IVF and PGD is highly demanding, time consuming, and has an emotional impact on the couples undergoing the procedure. Although many studies have demonstrated a theoretical approval of using PGD to prevent passing on hereditary diseases, actual uptake is significantly lower (Cunningham et al 2015;Derks-Smeets et al 2014b;Donnelly et al 2013), perhaps because the process raises ethical and emotional issues for possible parents and may trigger decisional conflict both in general, for genetic disease carriers (Muller and Cameron 2016), and, specifically, for BRCA1/2 mutation carriers (Insogna et al 2017).…”

How do patient perceived determinants influence the decision-making process to accept or decline preimplantation genetic screening?

“…To meet the overall goal of providing one healthy child with each pregnancy (14), it is imperative for providers and patients using IVF and PGS to collaboratively make informed decisions with the assistance of a decision-making tool (15). A decision aid generated from this study may prove beneficial for patients in the future as a guide in the decision-making process.…”

Mixed method systematic review: the relationship between breast cancer risk perception and health‐protective behaviour in women with family history of breast cancer

“…All eligible papers were assessed for quality using the appraisal tool developed by Kmet et al (2004). This tool enables the assessment of both quantitative and qualitative papers using separate but comparable systems and this has frequently been used for mixed methods systematic reviews on similar topics (Legare et al 2008, Cunningham et al 2015, Paneque et al 2015. Two authors performed independent appraisals before discussing the outcomes.…”