How do patient perceived determinants influence the decision-making process to accept or decline preimplantation genetic screening?

Abstract

This is the first study, to the authors' knowledge, to identify and assess the determinants of the patient decision-making process when presented with the choice of PGS. Several factors contribute to the patient-perceived determinants when choosing to accept or decline PGS, including cost, religious and ethical beliefs and values, social and family support, provider influences, and the past reproductive experience of the patient.

Preimplantation Genetic Testing for Monogenic Kidney Disease

“…In our cohort, the main patient-reported reasons for declining preimplantation genetic testing were the time investment and perceived relatively low chance of a pregnancy going .12 weeks gestational age after preimplantation genetic testing, which is consistent with literature (21,30,40). Interestingly, in our cohort, time from the moment of first counseling to delivery of the first child was similar for preimplantation genetic testing couples and couples who did not have preimplantation genetic testing.…”

In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study

“…With the introduction of NGS, the cost of PGD-A is becoming increasingly affordable and enables embryo chromosome analysis in IVF (33,34). Different factors contribute to patient-perceived determinants when choosing to accept or decline PGD-A, including cost, religion, ethical values, social and family support, provider influences, and past reproductive experience of the patient (35). In the light of the present results, with the current trend toward single-embryo transfer, it could be argued that failure to investigate the chromosomal constitution of the preimplantation embryo to be transferred may raise ethical questions of its own (36).…”

A systematic review exploring the patient decision‐making factors and attitudes towards pre‐implantation genetic testing for aneuploidy and gender selection

“…Of the 25 full text publications that were examined, 10 met the inclusion criteria. 14,25,26,[32][33][34][35][36][37][38] Of the 15 studies that were excluded, one text was not available in English, two were duplicate studies and 12 were review or opinion…”

“…Four of the studies investigated patients using PGT-A and six studies examined those who used PGT for gender selection. To collect the data, five of the studies used questionnaires, 25,[32][33][34][35] three studies used an existing database [36][37][38] and two used semi-structured interviews. 14,26 Three of the studies collected data prior to treatment and seven collected their data retrospectively.…”