The Evaluation of Thyroid Diseases in Patients with Pemphigus Vulgaris

Kavala, Mukaddes; Kural, Esra; Kocatürk, Emek; Zindancı, İlkin; Türkoğlu, Zafer; Can, Burçe

doi:10.1100/2012/146897

Cited by 25 publications

(30 citation statements)

References 12 publications

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“…Of participants with PV in the present study, 31.22% (69/221) had been diagnosed with associated autoimmune diseases, while 26 (11.74%) of them had been diagnosed with thyroid diseases. Our findings were similar to previous reports . Leshem et al .…”

Section: Discussionsupporting

confidence: 94%

Epidemiology of pemphigus vulgaris in the Northeast China: A 10‐year retrospective study

Zhu

jisheng

et al. 2013

The Journal of Dermatology

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The aim of the present study was to evaluate the incidence, epidemiological, clinical and therapeutic features of patients with pemphigus vulgaris in China. We retrospectively investigated a total of 221 patients with pemphigus vulgaris. The parameters including age at diagnosis/onset, sex, diagnostic methods, hospitalizations, side-effects with different treatments, pemphigus vulgaris-associated diseases, the therapeutic features and duration of follow up were evaluated. The male : female ratio was 1:1.40. The incidence rate was obviously higher in two age groups, 31-40 years and 41-50 years. The mean age at onset was 44.19 AE 21.45 years. The majority of patients (56.56%) presented the mucocutaneous type. In addition, we found that various doses of corticosteroids (including the mean initial dose, maximum control dose, total dose before reducing and hospitalized total dose) exhibited statistical differences between only corticosteroids and corticosteroids-immunosuppressant groups in mild, moderate and severe pemphigus vulgaris (P < 0.05). Our survey suggested that pemphigus vulgaris most frequently occurred in the 41-50-year age group in China and the majority of patients manifested mucocutaneous lesions. Importantly, the incidence rate in females was higher than in males. The patients who needed combined immunosuppressant treatment, usually needed higher doses of corticosteroids initially, to control the disease and over the total course of treatment.

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Section: Discussionsupporting

confidence: 94%

Epidemiology of pemphigus vulgaris in the Northeast China: A 10‐year retrospective study

Zhu

jisheng

et al. 2013

The Journal of Dermatology

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“…Diabetes mellitus occurs as an autoimmune response against BP antigens, which is transformed by the glycosylation of proteins at the dermo-epidermal junction in pemphigoid patients (18). In the literature it is reported that the frequency of autoimmune thyroid disease varies between 0% and 16% in pemphigus patients (6,25), but in a study conducted by Uzun et al it was found that thyroid pathologies were the most common comorbidities in pemphigus patients (3). Nonetheless, the most common comorbidity was diabetes mellitus and then hypothyroidism, with a rate of 7.7% in our pemphigus study group.…”

Section: Discussionmentioning

confidence: 99%

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

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IntroductionAutoimmune bullous diseases (ABDs) are a group of rarely seen organ-specific diseases caused by pathogenic autoantibodies against target antigens that function in the intercellular or the mesenchymal/dermal junction of the epidermis. Clinically, ABDs display quite a wide spectrum of vesicle or bulla formations on the skin and/or the mucous membranes. ABDs are classified mainly as intraepidermal bullous disease (pemphigus) and subepidermal bullous diseases (pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa), according to the depth of blister formation on the skin and types of autoantibodies against structural proteins (1). Generally, pemphigus vulgaris (PV) and bullous pemphigoid (BP) form the greater portion of ABDs, and therefore they are the most frequently known ABDs (1,2).The demographic, clinical, and etiological characteristics of ABDs and the incidence of subgroups vary according to geographic regions (1,2). In Turkey, despite the absence of national data, the first annual incidence estimations in the Mediterranean and Aegean regions of the country were reported as 2.4 and 1.8 per million by Uzun et al. and Bozdag and Bilgin, respectively (3,4). However, it was observed that these limited numbers of published data were of retrospective nature and focused on pemphigus only (3-5). Nevertheless, one of the two recently published retrospective studies from Turkey covered pemphigus with other ABDs, and the other included patients with hereditary bullous diseases and other ABDs (6,7). In this study we aimed to evaluate demographic data, clinical characteristics, related triggering factors, and comorbidities of newly diagnosed patients with ABDs at our clinic.Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Materials and methods:In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined. Furthermore, the distribution of lesions and autoimmune bullous skin disorder intensity scores were recorded.Results: Of the total 59 ABD patients, 26 (44.1%) were diagnosed with pemphigus, 25 (42.4%) were diagnosed with pemphigoid, and 8 (13.5%) were diagnosed with dermatitis herpetiformis. Although there were some differences between the subgroups of ABDs, the onset of the disease was associated with a triggering factor (stress, foods, physical trauma, chemical agents, ultraviolet rays, medications, infections, malignancies, and pregnancy, in a decreasing frequency) in 96.6% of the patients. Autoimmune diseases, ...

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“…Therefore, we searched for recent reports on screening studies of TgAb and TPOAb. To avoid the influence of diseases themselves, we only considered studies done on healthy control subjects in various regions in different countries [24][25][26][27][28][29][30][31][32][33][34][35][36][37]. In healthy subjects, the incidence of positive TgAb or TPOAb is …”

Section: Discussionmentioning

confidence: 99%

Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases

et al. 2017

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The Evaluation of Thyroid Diseases in Patients with Pemphigus Vulgaris

Cited by 25 publications

References 12 publications

Epidemiology of pemphigus vulgaris in the Northeast China: A 10‐year retrospective study

Epidemiology of pemphigus vulgaris in the Northeast China: A 10‐year retrospective study

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Comparison of thyroglobulin and thyroid peroxidase antibodies measured by five different kits in autoimmune thyroid diseases

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