The Evaluation of the Effects of Nanoemulsion Formulations Containing Boron and/or Zinc on the Wound Healing in Diabetic Rats

Gündoğdu, Gülşah; Nalcı, Kemal Alp; Kaplan, Afife Büşra Uğur; Gündoğdu, Köksal; Demirci, Tuba; Miloğlu, Fatma Demirkaya; Hacımüftüoğlu, Ahmet; Çetin, Meltem

doi:10.1177/1534734620961892

Cited by 12 publications

(9 citation statements)

References 29 publications

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“…Animals treated with the NE containing a low concentration of BFA demonstrated complete epithelialization and an entirely closed wound area within 14 days. This study showed encouraging results in the wound healing of diabetic rats [82].…”

Section: Nanoemulsionmentioning

confidence: 52%

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

et al. 2021

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The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediated functional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, leading to patient incompliance and lack of treatment. Nanotechnology in diabetes studies has encouraged the development of new modalities for measuring glucose and supplying insulin that hold the potential to improve the quality of life of diabetics. Other therapies, such as β-cells regeneration and gene therapy, in addition to insulin and oral hypoglycemic drugs, are currently used to control diabetes. The present review highlights the nanocarrier-based drug delivery systems and emerging treatment strategies of DM.

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Section: Nanoemulsionmentioning

confidence: 52%

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

et al. 2021

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“…Wound healing, which starts with in ammation, continues with proliferation and ends with regeneration, is a regular and programmed sequence of events in itself. Factors such as oxygenation, infection, age and sex hormones, stress, diabetes, obesity, drugs, alcoholism, smoking and nutrition can affect one or more phases of this process and cause inaccurate or impaired wound healing [19]. The effects of the wound healing process and the therapeutics used in the wound healing process should be well documented in order to have smooth and / or rapid wound healing and to reduce / eliminate the effects of the factors that adversely affect wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of the wound healing process and the therapeutics used in the wound healing process should be well documented in order to have smooth and / or rapid wound healing and to reduce / eliminate the effects of the factors that adversely affect wound healing. Formulas containing boric acid have been previously used in the literature to accelerate the wound healing process and its effectiveness has been demonstrated [11,15,19].…”

Section: Discussionmentioning

confidence: 99%

“…[14,20,21]. Boron participates in hydroxylation reactions and in addition to its use in musculoskeletal diseases and cardiovascular diseases, it acts as an anti-in ammatory and antioxidant agent in cancer, reducing genotoxicity and modulating mitochondrial membrane activity [1,20,22,23] When wound healing is examined, topically applied boric acid is effective in wound healing; It has even been reported that 3% boric acid solution reduces the duration of stay in intensive care units by 2/3 in deep wounds [12,19,24]. In this study, boron did not show a statistically signi cant difference with the control group in terms of ICI (p = 0.564), while it was found that the ICI score in the boron group was statistically signi cantly lower than the Plu and Fito groups (p values, respectively, 0.002, 0.018).…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Topically Applied Boric Acid on Ephrin-Eph Pathway in Wound Treatment: An Experimental Study

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et al. 2021

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Background: Wound healing has a vital importance for the organism and various agents are used to accelerate wound healing. Although the effect of boron on wound healing is known, its mechanisms are not completely clear yet. In this study, the effect of boron in the Ephrin /Eph pathway will be evaluated.Methods and Results: Forty adult female rats were used in the study. A full-thickness excisional wound model was created in all groups divided as control, Fito cream, Boric acid and Pluronic gel groups. Histopathologically, inflammatory cell infiltration(ICI), edema and fibroblast proliferation density(FPD); immunohistochemically TNF-α(Tumor necrosis factor α), EphrinA1, EphrinB1, EphrinB2 and EphB4 antibodies were evaluated in the skin tissues obtained after the applications performed twice a day and lasting 7 days.The ICI score was found to be higher in the Fito group compared to the boron group(p=0.018). FPD was higher in Plu group than boron group(p=0.012). While TNF-α was lower in boron group than Plu(p=0.027) and Fito(p=0.016) groups, EphrinA1 was higher in Boron group than plu group(p=0.005). EphrinB1 expression was higher in Boron group compared to Plu(p=0.015) and Fito(p=0.015) groups, and the same difference was also observed in EphrinB2 (p values 0.000). Similarly, EphB4 immunoreactivity was higher in the Boron group compared to the plu(p=0.000) and Fito(p=0.002).Coclusion: One of the mechanisms of action of boron in wound healing is to increase EphrinB1, EphrinB2 and EphB4. Low TNF-α and histopathological findings indicate that boron limits extensive wound healing.

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“…Also, boric acid limits oxidative damage by augmenting the glutathione storage of the body and inhibiting other ROS [22,25]. While there is known to be scientific research into the biological properties of various trace elements [26], those of Se and B have been investigated by a very limited number of studies. Therefore, the present study aims to compare the protective effects of Se and B upon CP-induced bone marrow and hematological toxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

Selenyum ve Bor'un Siklofosfamid kaynaklı kemik iliği ve kan toksisitesine karşı koruyucu etkileri: Bir in vivo çalışma

et al. 2022

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Bor (B) ve Selenyum (Se), antioksidan, anti-apoptotik, anti-lipid peroksidatif ve bağışıklık güçlendirici özellikleri sayesinde insan vücudu için gerekli eser elementlerdir. Bu çalışma, Se ve B'nin Siklofosfamid (SFD) ile indüklenen kemik iliğinde miyeloid koruyucu potansiyellerini ve bu anti-kanser ilacın miyelotoksik özelliğinin kullanımını sınırladığını göz önünde bulundurarak deneysel sıçanlarda hematolojik toksisiteyi karşılaştırmayı amaçlamaktadır. SFD'nin kemik iliği ve kan hücreleri üzerindeki toksik etkilerini önlemede selenyumun bordan daha iyi bir koruyucu etkiye sahip olduğunu varsaydık. Bu eser elementlerin en sık kullanılan optimal dozları olan 1.5 mg/kg Se ve 20 mg/kg B hayvanlara deney boyunca intraperitoneal olarak verildi. Sadece 4. günde 200 mg/kg SFD uygulandı. Hayvanlar sakrifiye edilerek hematolojik değerlendirmeler için kan ve kemik iliği örnekleri alındı. SFD uygulaması, lökosit (WBC), trombosit (PLT), eritrositler (RBC) ve kemik iliği çekirdekli hücre sayılarını önemli ölçüde azalttı. Öte yandan, SFD ile birlikte Se ve B verilen gruplarda, sadece SFD verilenlere göre önemli miktarlarda arttı. Ancak Se'nin, istatistiksel anlamlılık elde edememesine rağmen, SFD'nin neden olduğu kemik iliği ve hematolojik toksisiteyi önlemede B'den daha koruyucu olduğu kanıtlanmıştır. Bu nedenle, bu deneyde kullanılan dozların, kemik iliğinde SFD'nin neden olduğu hasara ve SFD'e bağlı hematolojik toksisiteye karşı korumada başarılı olduğu sonucuna varıldı.

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The Evaluation of the Effects of Nanoemulsion Formulations Containing Boron and/or Zinc on the Wound Healing in Diabetic Rats

Cited by 12 publications

References 29 publications

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

The Effect of Topically Applied Boric Acid on Ephrin-Eph Pathway in Wound Treatment: An Experimental Study

Selenyum ve Bor'un Siklofosfamid kaynaklı kemik iliği ve kan toksisitesine karşı koruyucu etkileri: Bir in vivo çalışma

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