The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones

Abstract

Objective: Medical expulsive therapy is an important non-invasive treatment modality that facilitates the passage of ureteral stones. The aim of the present study was to evaluate the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm. Material and methods: Data of 103 patients were retrospectively analyzed. Patients were divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50). Comparisons of stone expulsion rates and the elapsed time until the expulsion between the groups were determined as primary outcome measures. The comparison of the need for additional treatment [ureteroscopy (URS) or extracorporeal shock wave lithotripsy (ESWL)], the need for emergency admission, analgesic requirement, and the complication rates in additional treatment were determined as secondary outcome measures. Results: The mean age of the patients was 45.8±14.5 years. The rate of stone expulsion was significantly higher (82% vs. 66%, p= 0.026), and elapsed time to stone expulsion was significantly shorter (9±1.8 vs. 14±2.3 day, p= 0.018) in the V. opulus group. The need for additional treatment (URS and ESWL) and analgesic requirement was less in the V. opulus group (9.4% vs. 20%, p= 0.038 and 24.5% vs. 44%, p= 0.042, respectively). Conclusion: V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results.

Gilaburu extract ( Viburnum opulus Linnaeus) is as effective as Tamsulosin in medical expulsive therapy of distal ureteral calculi

“…The anti‐spasmolytic, anti‐urolitiatic, anti‐inflammatory, antinociceptive and antioxidant properties of this plant content, which is used commonly in Central Anatolia in Turkey, were proved for the urinary system in animal experiments. However, human studies on VO are very few 3,9‐11 …”

Viburnum opulus Fruit Phenolic Compounds as Cytoprotective Agents Able to Decrease Free Fatty Acids and Glucose Uptake by Caco-2 Cells

“…A high content of polyphenolic compounds has been identified in Viburnum opulus (guelder rose) berries, such as hydroxybenzoic acids, tannins, anthocyanins, chlorogenic acid, (+)-catechin, (−)-epicatechin, cyanidin-3 glucoside, cyanidin-3-rutinoside and quercetin [2,3]. Due to the antioxidant, antibacterial, hepatoprotective, high blood pressure-lowering and anti-inflammatory activities of Viburnum , these fruit have been used as a traditional medicine for treatment of ureteral stones, and cardiovascular or gastrointestinal diseases [4,5,6]. Whilst the plant is well known in Eastern Europe and Turkey (as gilaburu), where it can be found in food products such as juice, jams, jellies, marmalades and fermented drinks, in Western countries, as well as in Poland, is largely unused [7].…”

Fruits of new selection forms and varieties of snowball tree for manufacture of products of therapeutic and prophylactic purpose

“…Savieliev et al (2010), Golubieva et al (2016), Zhidekhina et al (2016 reported that green fruits (unlike ripe fruits) are rich in quinic and caffeic acids, the content of which significantly reduces during ripening. Ersoy et al (2017), Goszcz et al (2017), Cory et al (2018), Kızılay (2019) found that the fruits of the snowball tree contain triterpene compounds: α-and β-amyrin, alanolic and hedrogenic acids and their acetyl derivatives, ursolic acid, as well as steroids represented by phytosterol. Česonienė et al (2010), Shchetilina et al (2016) studied a broad range of biologically active substances, including antioxidants, providing new opportunities of using raw materials from the snowball tree in production of pharmaceuticals.…”