Gilaburu extract ( Viburnum opulus Linnaeus) is as effective as Tamsulosin in medical expulsive therapy of distal ureteral calculi

Abstract

Background To compare the extract of Gilaburu (Viburnum opulus Linnaeus) and Tamsulosin as a medical expulsive therapy (MET) in patients with distal ureteral calculi of 10 mm or less. Methods Data of 86 patients were prospectively collected. The patients were divided into two groups. In the first group, Viburnum opulus 1000 mg peroral 3 × 2 and diclofenac 50 mg peroral on‐demand (n = 43), in the second group Tamsulosin 0.4 mg peroral 1 × 1 and diclofenac 50 mg peroral on‐demand (n = 43) was given for MET in patients with distal ureteral calculi. Stone expulsion rates, time until expulsion, additional analgesic requirement, need for emergency admission, need for additional treatment were evaluated. In addition, subgroup analyses of ≤5 and 5‐10 mm were also performed. Results There was no difference between the groups in terms of stone expulsion rates and time until the expulsion in all stones. Additional analgesic requirement and need for emergency admission were found to be lower in the Viburnum opulus group (37.2% vs 65.1%, P = .017 and 11.6% vs 34.8%, P = .02, respectively). In subgroup analyses, while stone expulsion rates were similar in subgroups, it was found shorter in the time until expulsion, lower additional analgesic requirement and need for emergency admission in V. opulus group than Tamsulosin group in 5‐10 mm stone size subgroup (7.1 ± 4.2 vs 11.8 ± 5.2, P = .005, 32.2% vs 77.7%, P = .001 and 12.9% vs 40.7%, respectively). Conclusion V. opulus can be used effectively and safely for the treatment of MET in distal ureteral calculi.

The Role of the Tamsulosin in the Medical Expulsion Therapy for Distal Ureteral Stones

“…The method considered beneficial is discovered to have an adverse impact on patient health. The findings are supported by various studies, such as those presented by Abdel Rahim et al and Gok et al, in which the researchers concluded the spontaneous passing method causes complications among patients 18,19 . MET is therefore considered effective in the clinical treatment of patients, specifically in the case of ureteral stones, as it initiates the process of passing stones, which commonly takes 6 weeks following the onset of symptoms.…”

Effects on quality characteristics of ultrasound-treated gilaburu juice using RSM and ANFIS modeling with machine learning algorithm

“…V. opulus fruit contains high amounts of polyphenols [6] , phenolic acids [7] , flavonoids and anthocyanins [8] . The health benefits have been proven in studies thanks to its rich content of bioactive substances [9] , [10] , [11] , [12] , [13] .…”