The Evaluation of Oxidative Stress in the Serum and Tissue Specimens of Patients With Chronic Otitis Media

Garça, Mehmet Fatih; Turan, Mahfuz; Avşar, Barış; Kalkan, Ferhat; Demır, Halit; Kozan, Ahmet; Bozan, Nazım

doi:10.3342/ceo.2015.8.2.97

Cited by 9 publications

(16 citation statements)

References 24 publications

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“…In our study, the MDA levels in the patients group with CSOM with and without cholesteatoma and cholesteatoma recidivism were higher compared to the healthy group, which reflect an increased lipid peroxidation, a result similar to a 2015 study [22]. According to Holecek et al,lipoperoxidation may be a marker of disease severity in otitis media,being involved in many other otorhinolaryngological diseases [23][24][25].…”

Section: Resultssupporting

confidence: 76%

The TAC and MDA Values in Patients with Chronic Suppurative Otitis Media

Şerban¹,

Bădescu²,

Palade³

et al. 2019

Rev. Chim.

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The oxidative stress is linked to many chronic diseases.The aim of the study was to assess the oxidative stress in chronic suppurative otitis media. The prospective study included a group of 60 patients with different forms of chronic suppurative otitis media (CSOM), cholesteatoma recidivism and a control group of 30 healthy people. The total antioxidant capacity (TAC) and malondialdehyde (MDA) concentrations were determined in serum of thepatients. We noticed a significant lower mean of TAC levels (p[ 0.001) in patients with chronic suppurative otitis media (CSOM) with and without cholesteatoma compared to the control group. The MDA had significantly higher mean values (p[ 0.001) compared to the healthy group.The imbalance of antioxidant systems to oxidizing molecules plays an important role in the pathogenesis of CSOM with and without cholesteatoma.

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Section: Resultssupporting

confidence: 76%

The TAC and MDA Values in Patients with Chronic Suppurative Otitis Media

Şerban¹,

Bădescu²,

Palade³

et al. 2019

Rev. Chim.

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“…Previously, Garca et al found significantly elevated serum and tissue sample levels of malondialdehyde which was a marker of lipid peroxidation and decreased levels of antioxidant enzymes like superoxide dismutase, catalase and glutathione peroxidase. [20] To the best of our knowledge, this is the first study that investigated thiol/disulphide homeostasis as a novel marker of oxidative stress in patients with COM and compared the results with healthy controls.…”

Section: Discussionmentioning

confidence: 98%

“…This persistent inflammatory stimulation causes pathologic changes in the tissues and inhibits healthy tissue recovery. Moreover, oxidative stress can damage ciliary structure by damaging cellular DNA and protein, [19,20] thus leading to increased damage in the Eustachian tube and middle ear. In summary, the peroxidation of phospholipids in the cell membranes of the middle ear can prolong the duration of inflammation and thus lead to chronicity.…”

Section: Discussionmentioning

confidence: 99%

Thiol-disulphide homeostasis in noncomplicated chronic otitis media

Bozdemir¹,

Ulusoy²

2019

Journal of Contemporary Medicine

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Introduction: We hypothesized that oxidative stress plays a role in the pathogenesis of chronic otitis media, chronic mucosal inflammatory disease. We aimed to investigate a novel oxidative stress marker in this study. Methods: Thirty patient with chronic otitis media as the patient group and 30 healthy volunteer subjects as the control group were admitted to the study. Blood samples were taken when they admitted to our clinic before surgical intervention. In healthy volunteers, blood samples were taken when they were admitted to our policlinic. Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu. Results: 30 subjects were included in chronic otitis media group (20 females, 10 males). 30 subjects were included in the control group (8 females and 22 males). Sex distribution within the groups was significantly different (p=0.004). There was no significant difference between groups with respect to the age distribution (p=0.072). Measured native thiol, disulphide and total thiol values of the groups were not significantly different from each other. Discussion and Conclusion: This study demonstrated that although dynamic thiol/disulphide homeostasis was shifted towards disulphide formation as a result of thiol oxidation in patients with chronic otitis media. But we could not find any significant difference between groups.

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“…There is a minimal number of studies about oxidant and antioxidant mechanisms in patients with COM extant in the literature. [1,6,12,24] However, that a relationship between oxidative stress and COM exists is noteworthy.…”

Section: Discussionmentioning

confidence: 99%

“…A discharge lasting for more than three months is also present. [1] Even though it is accepted that COM is multifactorial in aetiology, the precise pathogenic mechanism has yet to be fully elucidated. [2][3][4] Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokine profile alterations, the presence of endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation which lies at the heart of the disorder.…”

Section: Introductionmentioning

confidence: 99%

Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media

Durmuş¹,

Kurtulgan²,

Bora³

et al. 2019

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Objective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation w hich l ies a t t he h eart of t he d isorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene. Methods: We investigated 49 patients admitted to the Otorhinolaryngology Department of Cumhuriyet University and diagnosed with COM between September and November 2017. The control group consisted of 51 healthy individuals. Polymerase chain reaction (PCR) -restriction fragment length polymorphism (RFLP) methods were used to genotype the PON1 Q192R (rs662) polymorphism.Results: When the case and control groups were compared in terms of the existence of PON1 (Q192) polymorphism, there was no statistically significant difference between the groups (p=0.166, p>0.05). When intergroup comparison was performed on the type of PON1 (Q192) polymorphism, there was also no statistically significant difference (p=0.261, p>0.05). Conclusion:The present study is the first known study in which PON1 polymorphism has been examined in cases of COM. The results of our study failed to indicate a statistically significant relationship between PON1 polymorphism and COM. However, it is important to note that the higher rate of 192RR polymorphism within the control group may indicate a protective effect in COM.

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The Evaluation of Oxidative Stress in the Serum and Tissue Specimens of Patients With Chronic Otitis Media

Cited by 9 publications

References 24 publications

The TAC and MDA Values in Patients with Chronic Suppurative Otitis Media

The TAC and MDA Values in Patients with Chronic Suppurative Otitis Media

Thiol-disulphide homeostasis in noncomplicated chronic otitis media

Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media

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