The evaluation of inflammatory, anti-inflammatory and regulatory factors contributing to the pathogenesis of COPD in airways

Vitenberga, Zane; Pilmane, Māra; Babjoniševa, Aurika

doi:10.1016/j.prp.2018.10.029

Cited by 23 publications

(31 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cigarette-years of smoking were assessed. Body mass index (BMI) was calculated as weight (kg)/height(m) 2 . Education was recorded as a 3-step scale, basic education or less than a high school degree, intermediate education with a high school degree but less than a 4-year degree, or advanced education with a 4-year degree or beyond.…”

Section: Demographic and Other Confounding Variablesmentioning

confidence: 99%

Association of Carotenoid Intake with Pulmonary Function

Jun

Root

2020

Journal of the American College of Nutrition

View full text Add to dashboard Cite

Lung function gradually declines as adults age, which can make breathing more difficult. Previous studies have reported enhanced lung function among older adults with high intake of carotenoid-rich foods. The aim of this study is to investigate the association between carotenoid-rich diet and lung function. Data were taken from the Atherosclerosis Risk in Communities (ARIC) study, which included approximately 15,000 individuals aged 45-64 years at baseline from each of four counties in the United States. Food frequency questionnaire (FFQ) data were used to assess dietary intake of carotenoid-rich foods. Total carotenoids intake was calculated by adding five specific carotenoids-α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin. Pulmonary function was evaluated as the ratio of forced expiratory volume in one second [FEV1] and forced vital capacity [FVC]. Linear regression analysis was used to assess the association between intake of carotenoids and pulmonary function. The association between the total carotenoid intake with pulmonary function was marginally positively significant; however, α-carotene, β-carotene, and β-cryptoxanthin intakes were individually significantly associated with a higher FEV1/FVC ratio in study participants. Dietary sources of pro-vitamin A carotenoids include yellow/orange fruits and vegetables such as oranges and sweet potatoes. Higher intake of these foods may improve pulmonary function.

show abstract

Section: Demographic and Other Confounding Variablesmentioning

confidence: 99%

Association of Carotenoid Intake with Pulmonary Function

Jun

Root

2020

Journal of the American College of Nutrition

View full text Add to dashboard Cite

show abstract

“…The cytokine IL-8 is one of the most active and widespread biological molecules, with a pro-inflammatory role, as it has chemotactic properties for immune cells. 37 In addition, IL-8 is also associated with increased mucus production and remodeling processes that affect the airways. 37 In an in vitro experiment, Dziurla et al showed that oxygen deprivation can facilitate inflammatory reactions, 48 which may explain the negative correlations found in the present study, that is, lower oxygen values in peripheral blood, and higher proportions of CD4+ T lymphocytes that express IL-8+.…”

mentioning

confidence: 99%

<p>Systemic Cytokine Profiles of CD4+ T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD</p>

Uzeloto

Toledo-Arruda

Silva

et al. 2020

COPD

View full text Add to dashboard Cite

“…In particular, increased concentrations of TNF-α and IL-6 were demonstrated in induced sputum in stable COPD [4,5]. Immunoreactive cells positive for interleukin-1α (IL-1α), IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, and TNF-α were detected in lung tissue of COPD patient significantly higher than in control group [6]. Recent studies have demonstrated that polymorphisms in proinflammatory genes are significantly associated with the susceptibility and severity of COPD [7,8].…”

Section: Introductionmentioning

confidence: 95%

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Kirichenko

Sobenin

Markina

et al. 2020

Biology

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease, in which systemic inflammation plays a key role. This 6-month randomized double-blinded placebo-controlled study evaluates the possible effect of natural preparation Inflaminat on clinical symptoms of COPD, indicators of respiratory function, and exacerbation frequency in 60 patients with moderate severity of COPD. Inflaminat is a combination of natural ingredients black elder (Sambucus nigra L.) berries, violet (Viola tricolor L.) herb, and calendula (Calendula officinalis L.) flowers. The preparation has been previously demonstrated to possess anticytokine and anti-inflammatory effects in experimental studies. In present study, COPD dynamics were evaluated by means of BCSS (Breathlessness, Cough, and Sputum Scale) and spirometry tests. It was shown that 6-months Inflaminat administration led to significant decrease of BCSS points from 3.0 ± 0.6 to 1.9 ± 0.7, (p = 0.002) as well as significant increase of FEV1 from 66 ± 18% to 73 ± 17%, (p = 0.042); there were no beneficial dynamics in placebo group. Side effects associated with preparation administration were not identified. The results of the study suggest that Inflaminat may be employed in treatment of patients with moderate severity of COPD, since it has a positive effect on COPD symptoms according BCSS and indicators of respiratory function FEV1.

show abstract

The evaluation of inflammatory, anti-inflammatory and regulatory factors contributing to the pathogenesis of COPD in airways

Cited by 23 publications

References 53 publications

Association of Carotenoid Intake with Pulmonary Function

Association of Carotenoid Intake with Pulmonary Function

<p>Systemic Cytokine Profiles of CD4+ T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD</p>

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Contact Info

Product

Resources

About