The evaluation of in vitro cariogenicity of transgalactosylated oligosaccharide.

Abstract

Abstract:In vitro cariogenicity of transgalactosylated oligosaccharide (TOS) was examined using oral streptococci. The results were as follows:1. Purified TOS (TOS-P) was not utilized for growth and production of lactic acid by oral streptococci.The utilization value of TOS-P was lower than that of neosugar-P.2. Association of TOS-P and TOS-50 with adherence in oral streptococci was not recognized.3. Insoluble and soluble glucans from TOS-P and TOS-50 were not produced by GTase derived from S. mutans ATCC 25175 and S. sobrinus ATCC 33478.These results indicate that TOS is useful as a non-cariogenic sugar.