The evaluation of immunoregulatory markers in the course of neurointoxication by mercury over the post-exposure period

Бодиенкова, Г. М.; Рукавишников, В. С.; Боклаженко, Е. В.

doi:10.18821/0016-9900-2016-95-12-1138-1141

Cited by 5 publications

(1 citation statement)

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“…Studies have shown that IL-2 can induce paroxysmal firing in the hippocampal structure of rats and affect the synthesis and release of Glu and GABA in hippocampal neurons. In addition, in vitro studies have shown that IL-2 can cause an increase in Glu immune response neurons and a decrease GABA in immune-response neurons [ 53 ]. IL-2 exerts its biological effect by binding the IL-2 receptor on the cell membrane.…”

Section: Possible Effects Of Il-2 In Schizophreniamentioning

confidence: 99%

The Interrelation between Interleukin-2 and Schizophrenia

2022

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Interleukin-2 (IL-2) is a growth factor that regulates T-cell autocrine secretion and has long been considered to be closely related to immune response. With the advance in neuroinflammation theory and immunology research on schizophrenia, it is interesting and meaningful to discuss the possible role of IL-2 in schizophrenia. Here, we reviewed a series of studies published from the 1990s and found that IL-2 was closely associated with schizophrenia. For example, IL-2 is responsible for mediating toxic reactions, which are the causes of schizophrenia symptoms in patients, and such symptoms resolve after discontinuation of the drug. In addition, we focused on the changes of IL-2 in the onset, progression and treatment of schizophrenia and the possible mechanisms by which IL-2 affects schizophrenia. Our review suggests that IL-2 is associated with schizophrenia and plays a role in its pathogenesis, and progression IL-2 and sIL-2R could serve as potential biomarkers of schizophrenia.

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Section: Possible Effects Of Il-2 In Schizophreniamentioning

confidence: 99%

The Interrelation between Interleukin-2 and Schizophrenia

2022

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Changes in Inflammatory Mediators Depending on the Level of Depression in Workers Chronically Exposed to Mercury Vapors

2020

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Diagnostic value of IL-17 in neurointoxication with mercury

Бодиенкова

Валерьвна

2021

Med. immunol.

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It is known that sufficient changes are observed in cellular and humoral links of immune system upon chronic exposure vapors of metallic mercury. In previous studies, upon development and in the course of the chronic mercury intoxication (CMI) we revealed pronounced regular changes of inflammatory mediators (IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, TNFα), and showed an important role of autoimmune reactions affecting nervous tissue proteins. Over last 20 years, an increased interest was shown for interleukin 17 (IL-17) and its role in a number of inflammatory and autoimmune diseases. However, there is no data on its role in neurointoxication with mercury. Considering that IL-17 has proinflammatory activity and stimulates production of the individual cytokines, the goal of our work at the next stage of research, was to identify quantitative changes of serum IL-17 in patients with mercury neurointoxication of various severity, aiming to substantiate additional criteria for early and effective diagnosis of the disease.The study was performed in males chronically exposed to metallic mercury vapors with early signs of neurointoxication (n = 37), individuals diagnosed with CMI (n = 40), and “conditionally healthy” men (n = 34). Proper diagnosis confirmed by history of working contacts with a harmful industrial factor, and absence of comorbid pathologies served as inclusion criteria. Statistical processing of the results was carried out using the STATISTICA 6.0 application package (StatSoft, USA). The study has revealed a statistically significant increase in serum IL-17 concentrations, both in the patients with early signs of neurointoxication with metallic mercury vapors, and individuals with CMI, when compared with the comparison group, thus indicating its activation, and being consistent with results of several workers who showed an IL-17 increase in immunoinflammatory diseases. Correlation analysis has shown an association between IL-17 and inflammatory mediators, i.e., the patients with early signs of neurointoxication had an increased production of IL-17 accompanied by an increase in anti-inflammatory IL-10, whereas the CMI patients with an increase in IL-17 concentration showed a decrease in pro-inflammatory TNFα, thus confirming its role in immunopathogenesis of mercury neurointoxication. Further study of IL-17 involvement in the initiation and maintenance of chronic inflammation will not only contribute to better understanding of the disease origin, but also, most importantly, implication of novel, more effective treatments.

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The evaluation of immunoregulatory markers in the course of neurointoxication by mercury over the post-exposure period

Cited by 5 publications

References 1 publication

The Interrelation between Interleukin-2 and Schizophrenia

The Interrelation between Interleukin-2 and Schizophrenia

Changes in Inflammatory Mediators Depending on the Level of Depression in Workers Chronically Exposed to Mercury Vapors

Diagnostic value of IL-17 in neurointoxication with mercury

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