The evaluation of cosmetic and pharmaceutical emulsions aging process using classical techniques and a new method: FTIR

Masmoudi, H.; Dréau, Yveline Le; Piccerelle, Philippe; Kister, Jacky

doi:10.1016/j.ijpharm.2004.10.020

Cited by 113 publications

(81 citation statements)

References 21 publications

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“…5 En este caso, su elevada precisión hace posible la cuantificación de una sustancia en una mezcla compleja, no siendo necesaria una separación previa.…”

Section: Análisis Espectroscópico Ft-irunclassified

Aceite de almendras dulces: extracción, caracterización y aplicación

Hernández¹,

Zacconi²

2009

Quím. Nova

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Recebido em 17/7/08; aceito em 4/11/08; publicado na web em 2/4/09 SWEET ALMOND OIL: EXTRACTION, CHARACTERIZATION AND APPLICATION. The extraction of sweet almond oil at room temperature and reflux is an easy and accessible procedure to obtain natural oil in a laboratory scale for undergraduates' courses in chemistry and related areas. In this paper we show how the utilization of Fourier Transform Infrared (FTIR) spectroscopy can be interesting in the qualitative analysis of these oils. We also propose the preparation of three different skin creams to demonstrate the effective uses of sweet almond oil in cosmetics and pharmaceutical fields.Keywords: almond oil; sweet almonds; undergraduate course. INTRODUCCIÓNEl objetivo de este trabajo es proponer un experimento de química orgánica que involucre la extracción en frío y en caliente del aceite de almendras a partir de almendras dulces utilizadas comúnmente en las comidas; analizar las diferencias observadas según las temperaturas de extracción del mismo, caracterizarlo por FT-IR y utilizarlo en la preparación de cremas teniendo en cuenta sus propiedades.Es importante destacar que si bien los métodos de extracción de los productos naturales requieren largos tiempos y altas temperaturas, el trabajo experimental aquí propuesto, puede llevarse a cabo en un laboratorio de química, en una clase práctica de 4 h. Esta experiencia resulta muy conveniente para el alumno que cursa Química Orgánica experimental, ya que logra integrar sus conocimientos básicos al mismo tiempo que despierta su interés científico.De las 4 h totales de trabajo experimental, la primera hora se destina a la lectura y discusión de variados artículos mencionando las propiedades y usos del aceite de almendras, las dos horas siguientes se dedican a la extracción y caracterización del mismo y la última hora de clase se emplea en la preparación de tres cremas con diferentes aplicaciones.Esta experiencia fue optimizada en el Taller teórico-práctico Química de los Productos Naturales dictado en el Departamento de Química de la Universidad Nacional del Sur en el marco de la XVII Olimpíada Argentina de Química durante el año 2007. Generalidades de la almendraLa almendra, conocida como la reina de las rosas, de la familia de las rosáceas y del género Prunus, constituye una de las fuentes de alimentación más antiguas del mundo. 1 Su origen proviene de Asia central y su cultivo prosperó principalmente en España e Italia donde la planta encontró las condiciones ideales para su crecimiento. Posteriormente, los jesuitas españoles la llevaron a California, donde se encuentra el mayor centro de producción mundial.Además de ser apreciada por su sabor, por su valor nutritivo y por sus extendidos usos medicinales y cosmetológicos, la almendra también está asociada a la buena fortuna. En la antigüedad, en las bodas, los novios regalaban a los invitados cinco almendras dulces como símbolo de salud, fertilidad, suerte, riqueza y felicidad. Al contrario de las dulces, las almendras amargas fueron asociadas a la desgracia y...

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“…5 En este caso, su elevada precisión hace posible la cuantificación de una sustancia en una mezcla compleja, no siendo necesaria una separación previa.…”

Section: Análisis Espectroscópico Ft-irunclassified

Aceite de almendras dulces: extracción, caracterización y aplicación

Hernández¹,

Zacconi²

2009

Quím. Nova

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“…As well as surfactants, a hydrophilic polymer as a thickener is a popular stabilizing agent of emulsions. [20][21][22] The thickeners tested in this study include HEC, xanthan gum, and carbomers. At the beginning of this experiment, the concentration of the thickeners was fixed at 0.1%.…”

Section: Effects Of Thickeners On the Emulsion Stability Of The Creammentioning

confidence: 99%

Effect of Surfactants and Thickeners on the Stability of Menthol–Diphenhydramine Cream Identified by Magnetic Resonance Imaging

Onuki

Yokokawa

Utsumi

et al. 2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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A menthol-diphenhydramine cream is prepared in hospital pharmacies and then prescribed to patients for the treatment of pruritus associated with chronic kidney disease. The purpose of this study is to design a stable formulation without any concern about phase separation during its clinical use on patients. As a preventive measure against phase separation, various surfactants and thickeners were incorporated into the creams. The test creams were stored at 40°C, and then their phase separation behaviors were monitored. The key technology was magnetic resonance imaging T 2 mapping. From the T 2 maps, some surfactants showed a certain stabilizing effect. In addition, the data analysis using Kohonen's self-organizing map revealed that hydrophilic-lipophilic balance of the surfactant is an important factor for the stabilizing effects of the surfactants. However, as a whole, the effect of surfactant was not sufficient to improve completely the low stability. By contrast, the creams were significantly stabilized by addition of thickeners. In particular, the stabilizing effect of carbomer Hiviswako105 ® (H105) was very high; no phase separation was observed from the cream containing H105 even after 30 d storage at 40°C. This study also verified the combination effect of surfactants and thickeners on the improvement of the emulsion stability. In conclusion, we successfully established a stable formulation of menthol-diphenhydramine cream.

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“…This situation may be considered a sign of the instability of the emulsion. According Masmoudi et al (2005) there is not a linear relationship between the increase or decrease in conductivity and the instability, therefore other adjuvant methods should be used to evaluate the stability.…”

Section: Preliminary Stability Testsmentioning

confidence: 99%

“…Decreases in viscosity may be a sign of instability (Masmoudi et al, 2005). R1 and R3 emulsions showed increased viscosity after the freeze-defrost cycle and after thermal stress compared to the initial viscosity (Table II).…”

Section: Preliminary Stability Testsmentioning

confidence: 99%

Development of O/W emulsions containing Euterpe oleracea extract and evaluation of photoprotective efficacy

Daher

Fontes

Rodrigues

et al. 2014

Braz. J. Pharm. Sci.

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Euterpe oleracea Mart. is a palm tree popularly known as açai, which is primarily found in northern Brazil. The açai's fruits contain anthocyanins, a class of polyphenols to which antioxidant properties have been attributed. The aim of this work was to develop O/W sunscreens emulsions containing açai glycolic extract (AGE) and to evaluate both their physical stability and photoprotective efficacy. Emulsions containing AGE and sunscreens were formulated using different types and concentrations of polymeric surfactant (acrylates/C 10-30 alkyl acrylate crosspolymer and sodium polyacrylate). The influence of two rheology modifiers (polyacrylamide (and) C13-14/isoparaffin (and) Laureth-7 and Carbomer) on the stability was also investigated. Physical stability was evaluated by preliminary and accelerated studies. Emulsions with 1.0% sodium polyacrylate were stable and exhibited non-newtonian pseudoplastic behavior and thixotropy. Photoprotective efficacy was evaluated by in vivo Sun Protection Factor (SPF) and determination of Protection Factor of UVA (PF-UVA). When AGE was added to the sunscreen emulsion, no significant increase in the in vivo SPF value was observed. The emulsion containing AGE showed PF-UVA = 14.97, 1.69 of the SPF/PF-UVA ratio and a critical wavelength value of 378 nm, and may therefore be considered a sunscreen with UVA and UVB protection. Euterpe oleracea Mart. é uma palmeira popularmente conhecida como açaí, encontrada no norte do Brasil. O fruto do açaí apresenta em sua composição antocianinas, uma classe de polifenóis à qual é atribuída propriedade antioxidante. Os objetivos desse trabalho foram desenvolver emulsões fotoprotetoras O/A contendo extrato glicólico de açaí (AGE), avaliar a estabilidade física e avaliar a eficácia fotoprotetora. Emulsões contendo AGE e filtros solares foram formuladas utilizando diferentes tipos e concentrações de tensoativo polimérico (acrilates/C 10-30 alquil acrilato polímero cruzado e polilacrilato sódico). A influência de dois modificadores reológicos (poliacrilamida (e) C13-14/isoparafina (e) Laureth-7 e Carbomer) na estabilidade foi avaliada. A estabilidade física das emulsões foi avaliada por meio de estudos de estabilidade preliminar e acelerada. Emulsões com 1,0% poliacrilato sódico foram estáveis, exibiram comportamento não-newtoniano pseudoplástico e tixotrópico. A eficácia fotoprotetora foi avaliada pelo teste in vivo de Fator de Proteção Solar (FPS) e pela determinação do Fator de Proteção UVA (FP-UVA). Quando adicionado o AGE na emulsão contendo filtros solares, não se observou aumento significativo no valor do FPS. A emulsão contendo o AGE apresentou FP-UVA=14,97, a razão FPS/ FP-UVA = 1,69 e o comprimento de onda crítico igual a 378 nm, podendo ser considerado um protetor solar com proteção UVA e UVB. Unitermos:Emulsão O/A/desenvolvimento. Euterpe oleracea/farmacognosia. Euterpe oleracea/extrato glicólico/eficácia fotoprotetora. Protetores Solares/desenvolvimento. Fator de Proteção Solar.

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The evaluation of cosmetic and pharmaceutical emulsions aging process using classical techniques and a new method: FTIR

Cited by 113 publications

References 21 publications

Aceite de almendras dulces: extracción, caracterización y aplicación

Aceite de almendras dulces: extracción, caracterización y aplicación

Effect of Surfactants and Thickeners on the Stability of Menthol–Diphenhydramine Cream Identified by Magnetic Resonance Imaging

Development of O/W emulsions containing Euterpe oleracea extract and evaluation of photoprotective efficacy

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