The evaluation of brain perfusion SPECT using an easy Z-score imaging system in the mild cognitive impairment subjects with brain amyloid-β deposition

Takemaru, Makoto; Kimura, Noriyuki; Abe, Yoshitake; Goto, Megumi; Matsubara, Etsuro

doi:10.1016/j.clineuro.2017.06.018

Cited by 10 publications

(19 citation statements)

References 24 publications

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“…Information regarding age, sex and education level was collected, and cognitive function was assessed by a trained clinical psychologist using the MMSE and Clinical Dementia Rating . The diagnosis of amnestic MCI was made as per previous studies as follows: (i) subjective memory complaints and objective memory impairment; (ii) a score of 0.5 in the Clinical Dementia Rating; and (iii) absence of significant impairment in cognitive function or activities of daily living . The present prospective study was carried out in accordance with the Declaration of Helsinki, and was approved by the local ethics committee of the Oita University Hospital (B12‐013).…”

Section: Methodsmentioning

confidence: 99%

Diagnosis of mild cognitive impairment using multiple neuroimaging modalities in addition to the Mini‐Mental State Examination

Kaneko

Kimura

Nojima

et al. 2019

Geriatrics Gerontology Int

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Aim: This prospective study investigated the additional utility of combining multiple imaging modalities with the Mini-Mental State Examination (MMSE) in discriminating individuals with mild cognitive impairment (MCI) from cognitively normal individuals.Methods: A total of 103 individuals with amnestic MCI and normal cognitive function were recruited from outpatients; they underwent examination using the MMSE, magnetic resonance imaging, 18 F-fluorodeoxyglucose positron emission tomography and 11 C-Pittsburgh compound B positron emission tomography. Binary logistic regression with receiver operator characteristic analysis was used to assess the combination of the abovementioned single or multiple imaging modalities with the MMSE. Eight models were constructed, and their area under the curve values and misclassification rates in discriminating individuals with amnestic MCI from cognitively normal individuals were evaluated.Results: The addition of each of the imaging modalities improved the discrimination accuracy over that of the MMSE alone; the accuracy obtained with the addition of 18 Ffluorodeoxyglucose positron emission tomography was the highest. The best model with the highest accuracy included a combination of all the imaging modalities in addition to the MMSE (area under the curve value 0.902). Conclusions:The combination of all the imaging modalities in addition to the MMSE could facilitate more accurate diagnosis of amnestic MCI. Of the individual imaging modalities, the highest accuracy resulted from the addition of 18 F-fluorodeoxyglucose positron emission tomography to the MMSE.

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Section: Methodsmentioning

confidence: 99%

Diagnosis of mild cognitive impairment using multiple neuroimaging modalities in addition to the Mini‐Mental State Examination

Kaneko

Kimura

Nojima

et al. 2019

Geriatrics Gerontology Int

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“…Cutoff values for likely AD were > 1.19 for the severity, > 14.2% for the extent, and > 2.22 for the ratio [10]. Previous studies demonstrated that patients with abnormalities in all indicators exhibited PiB retention by PiB-PET [11,12].…”

Section: Ezis-spectmentioning

confidence: 99%

“…The easy Z-score imaging system (eZIS) (FUJIFILM RI Pharma, Co., Ltd., Tokyo, Japan) objectively evaluates the degree of reduction in rCBF in the PCC, precuneus, and parietal lobe, and automatically calculates three indicators that discriminate between AD patients and normal controls [10]. Because of these advantages, eZIS-SPECT is increasingly used for the diagnosis of AD [11,12].…”

Section: Introductionmentioning

confidence: 99%

Utility of Easy <b><i>Z</i></b>-Score Imaging System-Assisted SPECT in Detecting Onset Age-Dependent Decreases in Cerebral Blood Flow in the Posterior Cingulate Cortex, Precuneus, and Parietal Lobe in Alzheimer’s Disease with Amyloid Accumulation

Hayashi

Kobayashi

Kawakatsu

et al. 2020

Dement Geriatr Cogn Disord Extra

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Background: Easy Z-score imaging system (eZIS)-assisted SPECT accurately detects decreases in cerebral blood flow in the posterior cingulate cortex (PCC), precuneus, and parietal lobe, the cerebral regions deeply implicated in Alzheimer's disease (AD). Several studies suggested onset age-dependent decreases in cerebral blood flow in these regions in AD, but these studies did not screen for amyloid accumulation, suggesting inclusion of non-AD patients in their subjects. Objective: By applying eZIS-SPECT to patients with amyloid deposition, it was the aim of this study to clarify onset age-dependent decreases in cerebral blood flow in the regions critical to AD. Methods: We retrospectively analyzed eZIS-SPECT data on 34 AD patients with amyloid retention confirmed by 11 C-Pittsburgh compound B-PET. The subjects were divided into an early-onset group (n = 16) and a late-onset group (n = 18). The three indicators of the eZIS that had discriminated between AD patients and normal controls in previous studies were compared between the two groups. Results: The mean values for the respective indicators were significantly higher in the early-onset group than in the late-onset group. Also, the proportion of patients with abnormalities in all indicators was significantly higher in the

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“…18 F-labeled PiB (Florbetapir) was synthesized with NEPTIS ® plug-01, intravenously injected for 9 participants at an Okayama University-affiliated hospital, and 60-90 min later PET images were detected for 30 min. For two AD patients at Oita University, 11 C-PiB was injected to take PET images [9,10]. As the whole cerebellar region of interest (ROI) for reference, an average of standard uptake value (SUV) from 6 cerebral cortical areas were calculated in order to analyze positive or negative for PiB-PET (positive for more than 1, negative for 1 or less).…”

Section: Pet Imagingmentioning

confidence: 99%

“…Diagnosis of AD is usually based on clinical criteria, but may be supported by biochemical markers such as a decreased amyloid-␤ (A␤) 42 [3], and increased A␤ oligomer [4,5] and tau protein in cerebrospinal fluid (CSF) [3]. Radiological analyses are also sometimes undertaken as supportive biomarkers of AD with single photon emission computed tomography (SPECT) for evaluating cerebral blood flow [6,7] and positron emission tomography (PET) for A␤ using Pittsburgh compound B (PiB) [8][9][10] and tau [11][12][13]. However, blood samples are more feasible and plausible than CSF or radiological biomarkers for screening emerging number of potential AD and other dementias [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer’s Disease by Peptidome Technology

Abe

Shang

Shi

et al. 2020

JAD

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Background: Because dementia is an emerging problem in the world, biochemical markers of cerebrospinal fluid (CSF) and radio-isotopic analyses are helpful for diagnosing Alzheimer's disease (AD). Although blood sample is more feasible and plausible than CSF or radiological biomarkers for screening potential AD, measurements of serum amyloid-␤ (A␤), plasma tau, and serum antibodies for A␤ 1-42 are not yet well established. Objective: We aimed to identify a new serum biomarker to detect mild cognitive impairment (MCI) and AD in comparison to cognitively healthy control by a new peptidome technology. Methods: With only 1.5 l of serum, we examined a new target plate "BLOTCHIP ® " plus a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) to discriminate control (n = 100), MCI (n = 60), and AD (n = 99). In some subjects, cognitive Mini-Mental State Examination (MMSE) were compared to positron emission tomography (PET) with Pittsburgh compound B (PiB) and the serum probability of dementia (SPD). The mother proteins of candidate serum peptides were examined in autopsied AD brains. Results: Apart from A␤ or tau, the present study discovered a new diagnostic 4-peptides-set biomarker for discriminating control, MCI, and AD with 87% of sensitivity and 65% of specificity between control and AD (* * * p < 0.001). MMSE score was well correlated to brain A␤ deposition and to SPD of AD. The mother proteins of the four peptides were upregulated for coagulation, complement, and plasticity (three proteins), and was downregulated for anti-inflammation (one protein) in AD brains.

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The evaluation of brain perfusion SPECT using an easy Z-score imaging system in the mild cognitive impairment subjects with brain amyloid-β deposition

Cited by 10 publications

References 24 publications

Diagnosis of mild cognitive impairment using multiple neuroimaging modalities in addition to the Mini‐Mental State Examination

Diagnosis of mild cognitive impairment using multiple neuroimaging modalities in addition to the Mini‐Mental State Examination

Utility of Easy <b><i>Z</i></b>-Score Imaging System-Assisted SPECT in Detecting Onset Age-Dependent Decreases in Cerebral Blood Flow in the Posterior Cingulate Cortex, Precuneus, and Parietal Lobe in Alzheimer’s Disease with Amyloid Accumulation

A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer’s Disease by Peptidome Technology

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