The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer

Demir, Nalan; Türksoy, Vugar Ali; Kayaaltı, Zeliha; Söylemezoğlu, Tülın; Savaş, İsmail

doi:10.5578/tt.7902

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Despite the limited number of studies showing that Cd has no association with lung cancer, recent studies have identified an increased risk of lung cancer in the population exposed to Cd. 109,110 It has been reported that Cd levels in 24-hour urine are positively associated with both lung cancer and total cancer risk.…”

Section: And Lungmentioning

confidence: 99%

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

et al. 2020

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Cadmium (Cd) is a significant ecotoxic heavy metal that adversely affects all biological processes of humans, animals and plants. Exposure to acute and chronic Cd damages many organs in humans and animals (e.g. lung, liver, brain, kidney, and testes). In humans, the Cd concentration at birth is zero, but because the biological half-life is long (about 30 years in humans), the concentration increases with age. The industrial developments of the last century have significantly increased the use of this metal. Especially in developing countries, this consumption is higher. Oxidative stress is the imbalance between antioxidants and oxidants. Cd increases reactive oxygen species (ROS) production and causes oxidative stress. Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles. This damage has been associated with various diseases. These include cancer, hypertension, ischemia/perfusion, cardiovascular diseases, chronic obstructive pulmonary disease, diabetes, insulin resistance, acute respiratory distress syndrome, idiopathic pulmonary fibrosis, asthma, skin diseases, chronic kidney disease, eye diseases, neurodegenerative diseases (amyotrophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease, and Huntington disease). Natural antioxidants are popular drugs that are used by the majority of people and have few side effects. Natural antioxidants play an important role in reducing free radicals caused by Cd toxicity. Our goal in this review is to establish the relationship between Cd and oxidative stress and to discuss the role of natural antioxidants in reducing Cd toxicity.

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Section: And Lungmentioning

confidence: 99%

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

et al. 2020

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“…In Beder's study, among 1068 pneumoconiosis patients, p-type and q-type opacities were the most common in 43.9% of cases, respectively. Type C opacities were found in 2.7% of cases, while type B and type A opacities were found in 2% of cases each [16]. Şakar et al reported the detection of p-and q-type opacities in 24 patients with pneumoconiosis [20].…”

Section: Discussionmentioning

confidence: 99%

“…Another study by İçmeli, which evaluated disability rates in coal worker pneumoconiosis cases, found that the average working time in the mines was 23 years [11]. Similarly, Beder's study on pneumoconiosis cases whose liability period expired revealed an average working period of 23.51 years [16]. These differences in working time can be attributed to the predominance of CWP patients in the studies of Liman, İçmeli, and Beder, while the majority of patients in our study had a diagnosis of silicosis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of loss of earning power in pneumoconiosis patients with occupational lung disease

Tetik,

Sogukpinar,

Icmeli

et al. 2023

Med-Science

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Occupational diseases are a category of diseases that are caused by exposure to risk factors. Pneumoconiosis is one of the occupational diseases. We aimed to analyze patients with pneumoconiosis whose diagnosis was finalized by the 3rd Forensic Medicine Specialization Committee (3rd FMSC) of the Forensic Medicine Institute (FMI). The study investigated various factors such as gender, diagnosis age, length of employment, workplace measurements of the causative agent, smoking history, pneumoconiosis subtypes, opacity types, Pulmonary Function Test (PFT) values, as well as decisions made by the Occupational Diseases Hospital (ODH), Social Security Institution (SSI), and Social Insurance High Health Board (SIHHB). Retrospective analysis was conducted on 369 patients with pneumoconiosis that received disability determination. All patients were male, with mean age at initial diagnosis of 44.25±11.86 years. The mean duration of occupational exposure was 16.32±7.54 years. Silicosis was the most common diagnosis. Occupational diseases were diagnosed in 95.7% of patients by the 3rd FMSC, with small opacity being the most prevalent subtype, particularly q2-p1 opacity among them, and B opacity being the most common among large opacities. Significant correlation was found between working hours and types of pneumoconiosis. However, no significant correlation was found between radiologically determined opacities by the 3rd FMSC and working duration. Examination of the decisions made by the 3rd FMSC, SIHHB, SSI, and ODH revealed the least agreement between ODH and other institutions. Regarding the diagnosis agreement of opacity densities between the 3rd FMSC, SIHHB, SSI, and ODH, the agreement between the 3rd FMSC and other institutions was the lowest. To evaluate disability caused by pneumoconiosis, it is recommended to utilize current technological advancements and provide comprehensive medical documentation. In the relevant regulations, it is suggested that a new regulation, involving branch specialists, should be developed to address the radiological, functional, and clinical aspects in comprehensive manner.r.

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Cadmium Levels in Tissue and Plasma as a Risk Factor for Prostate Carcinoma: a Meta-Analysis

Zeng

Zhu

Hao

et al. 2015

Biol Trace Elem Res

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Cadmium is a heavy metal that has been suggested to be a carcinogen by evidence. A number of published studies have investigated the association between cadmium levels and prostate cancer, but the results were inconsistent. Thus, we conducted a meta-analysis to get a precise estimate of this subject. After a careful searching and screening, a total of 11 publications containing 14 separated studies were included. Based on a random-effect model, the pooled data showed that cadmium levels of prostate tissues (standard mean difference (SMD) = 3.17, 95 % confidence interval (CI) = 0.60-5.74, P < 0.05) and plasma (SMD = 4.07, 95 % CI = 2.01-6.13, P < 0.05) were significantly higher in prostate cancer patients than those in the healthy controls. No difference of hair and nail cadmium levels between the prostate cancer cases and the controls was found. The data suggested that cadmium exposure might exert an influence on the tumorigenesis of prostate tissues. Future investigations with large sample sizes are needed to verify the results.

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The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer

Cited by 5 publications

References 26 publications

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

Evaluation of loss of earning power in pneumoconiosis patients with occupational lung disease

Cadmium Levels in Tissue and Plasma as a Risk Factor for Prostate Carcinoma: a Meta-Analysis

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