The eutopic endometrial response to chorionic gonadotrophin is abnormal in a baboon model of endometriosis: a possible explanation for endometriosis associated implantation failure

Hastings, Julie M.; Sherwin, Rob; Mavrogianis, Patricia A.; Jackson, Kevin; Sharkey, Andrew; Fazleabas, Asgerally T.

doi:10.1016/j.fertnstert.2008.07.286

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“…This is clearly evident in our baboon model of simulated pregnancy. Following the induction of endometriosis, the eutopic endometrium is unresponsive to chorionic gonadotrophin (CG) stimulation, and the expression of a number of genes thought to be critical for implantation and decidualization are markedly altered (Fazleabas et al, 2003;Hastings et al, 2008). The examination of steroid hormone responsiveness can elucidate the effectiveness of hormonal treatment of endometriosis and corroborate the finding of progesterone therapy resistance in some cases of endometriosis (Bulun et al, 2006;Burney et al, 2007).…”

Section: Steroid Hormone Responsivenessmentioning

confidence: 99%

The non-human primate model of endometriosis: research and implications for fecundity

Braundmeier

Fazleabas

2009

Molecular Human Reproduction

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The development of an animal model of endometriosis is crucial for the investigation of disease pathogenesis and therapeutic intervention. These models will enhance our ability to evaluate the causes for the subfertility associated with disease and provide a first-line validation of treatment modulators. Currently rodents and non-human primate models have been developed, but each model has their limitations. The aim of this manuscript is to summarize the current findings and theories on the development of endometriosis and disease progression and the effectiveness of therapeutic targets using the experimental induced model of endometriosis in the baboon (Papio anubis).

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