The non-human primate model of endometriosis: research and implications for fecundity

Abstract

The development of an animal model of endometriosis is crucial for the investigation of disease pathogenesis and therapeutic intervention. These models will enhance our ability to evaluate the causes for the subfertility associated with disease and provide a first-line validation of treatment modulators. Currently rodents and non-human primate models have been developed, but each model has their limitations. The aim of this manuscript is to summarize the current findings and theories on the development of endometriosis and disease progression and the effectiveness of therapeutic targets using the experimental induced model of endometriosis in the baboon (Papio anubis).

Reproductive Microbiomes: Using the Microbiome as a Novel Diagnostic Tool for Endometriosis

“…This animal model closely resembles lesion kinetics as seen in human disease [34] and use of non-human primates allows for repetitive surgical sampling for multiple time point analysis. Additionally, the inflammatory profile of endometriosis in this animal model mirrors what has been reported in human disease [35][36][37] making this an excellent parallel study for our currently reported data.…”

A Nonhuman Primate Model for Urinary Bladder Regeneration Using Autologous Sources of Bone Marrow-Derived Mesenchymal Stem Cells

“…During the initial phases of baboon fetal development, the urinary tract grows and develops comparably to humans accentuated by a late burst of growth during in late gestation [38]. A variety of studies in numerous fields comprising decades of research activity with NHPs as preclinical models have been used in the elucidation of physiological mechanisms [39][40][41]. As there is a paucity of information with regards to baboon bladder regeneration, our study is the first report on a NHP bladder augmentation model using an autologous source of BM MSCs.…”

Endometriosis-induced changes in regulatory T cells — insights towards developing permanent contraception

“…Baboons develop spontaneous endometriosis with ectopic lesions that are similar to those observed in women. An added advantage to the baboon model is that the disease can also be induced by injection of menstrual effluent into the pelvic cavity, which permits the study of disease progression from the initial onset of the disease [3, 40, 41]. …”