The Etiology of So-Called Schizophrenic Psychoses

Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study

“…Abnormalities of the septum pellucidum have been reported in some neuropsychiatric syndromes (Dandy, 1931;Wilder, 1938;Olsen, 1942 ;Zeman& King, 1958;Sarai, 1966;Morgan et al 1985;Miller et al 1986). In addition, since 1851, several cases of the association of psychosis with CSP have been reported (Verga, 1851;Finke & Koch, 1968;Lewis & Mezey, 1985) with some literature suggesting that congenital neural abnormalities are more frequent in schizophrenia (Rosanoff et al 1934;Rutter, 1986;Weinberger, 1987). The septal region is of theoretical interest in schizophrenia because dopaminergic pathways have crucial connections in the septal nuclei and nucleus accumbens.…”

No effect of obstetric complications on basal ganglia volumes in schizophrenia

“…The first description of early somatic trauma and neurodevelopmental disturbances as putative risk factors for schizophrenia dates back to Rosanoffs classic twin study "The etiology of the so called schizophrenic psychoses" from 1934. Although the twin concordance rates were the main objective of this study, he discussed the possibility of schizophrenia being a "decerebration syndrome which may result from birth trauma" (Rosanoff et al, 1934), based on the finding that birth trauma such as prematurity and the use of forceps were more frequent in the ill than in the healthy twins.…”

Contribuição para o tratamento convulsivante nos esquizofrênicos

“…Para nós a diferença essencial entre os diversos tipos da chamada esquizofrenia e as ocorrências patológicas superponíveis àqueles consiste em que no primeiro caso as desordens resultam de afecção primitiva do encéfalo ao passo que no segundo traduzem o modo de reagir ante condições mórbidas inicialmente extracerebrais. As demais características, por exemplo a predisposição hereditária (26), o tipo de personalidade (65,117,162), por outro lado a incidência positivada de fatores extrínsecos, quer predominantemente exógenos (59,125,138,184), quer de ordem moral (19,107,178), tanto podem interferir em uma como em outra das eventualidades patológicas há pouco lembradas; não servem pois, per se, como elemento diferencial.…”