The etiology of antisocial personality disorder: The differential roles of adverse childhood experiences and childhood psychopathology

DeLisi, Matt; Drury, Alan J.; Elbert, Michael J.

doi:10.1016/j.comppsych.2019.04.001

Cited by 66 publications

(36 citation statements)

References 67 publications

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“…We also found that AUD patients with ASPD had more adult ADHD symptoms and had experienced more childhood trauma, both of which are consistent with previous studies. [57][58][59][60] Furthermore, we found that the AUD patients with ASPD had more hazardous drinking behavior which also corresponds to earlier findings. 61 Antagonism and disinhibition predict hazardous alcohol use 62 and antisocial behavior is associated with increased lifetime alcohol problems.…”

Section: Discussionsupporting

confidence: 91%

Antisocial Personality Disorder Among Patients in Treatment for Alcohol Use Disorder (AUD): Characteristics and Predictors of Early Relapse or Drop-Out

Pandey

Bolstad

Lien

et al. 2021

SAR

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Background: Patients with alcohol use disorders (AUD) vary significantly in many clinically important characteristics making them a heterogenous group. AUD patients with comorbid antisocial personality disorder (ASPD) form an important sub-group, and studies indicate that these patients may have poorer treatment outcomes. Therefore, we aimed to investigate the characteristics of AUD inpatients with comorbid ASPD and identify predictors of early relapse or treatment drop-out in these patients. Methods: In a longitudinal study of AUD patients (n = 113; 30 females; aged 27 to 72 years) in treatment at three residential rehabilitation clinics in Norway, we used interviews and self-report questionnaires to collect data on alcohol use, mental health, and trauma experience. In addition, we assessed biochemical parameters. The patients were followed up at 6 weeks to identify early relapse or drop-out. Results: Prevalence of ASPD among AUD patients was 15%. AUD patients with comorbid ASPD were exclusively male, of younger age, and reported more childhood trauma, and adult attention-deficit-hyperactivity-disorder symptoms. They reported more hazardous drinking behavior and more often had dependence on substances in addition to alcohol. The presence of ASPD did not predict early relapse or drop-out. However, early relapse or drop-out in ASPD patients was associated with childhood and adult trauma, younger age of drinking debut, and higher baseline prolactin levels. Conclusion: AUD patients with ASPD had different clinical characteristics to other AUD patients and they had specific predictors of early relapse or drop-out. Our findings indicate that the early relapse or drop-out among AUD patients with ASPD may be attributed to environmental and possibly biological vulnerability. However, further studies with larger sample size are warranted to confirm these preliminary associations.

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Section: Discussionsupporting

confidence: 91%

Antisocial Personality Disorder Among Patients in Treatment for Alcohol Use Disorder (AUD): Characteristics and Predictors of Early Relapse or Drop-Out

Pandey

Bolstad

Lien

et al. 2021

SAR

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“…Poor parental management has been repeatedly demonstrated to be a leading factor in antisocial and delinquent behaviors (55). However, the aforementioned studies assess severe parenting abnormalities, such as violence in the home, removal from the home (55), parental neglect, parental drug use, sexual abuse (25), and severe poverty (56). Where subtle changes in parental warmth or hostility have been studied, changes in risk taking behaviors have been observed during periods of especially high or low hostility, and this lability was related to greater delinquency in girls but not in boys (28).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to frequently highlighted delinquency risk factors, such as suffering from parental separation (24), maltreatment, and harsh parenting (25,26), there is some evidence that withdrawn maternal communication (27), or lability between levels of warmth displayed by mothers (28), is also associated with a significantly higher risk for antisocial or delinquent behaviors in adolescents. These results are coherent with the fluctuating detachment seen in depressed mothers, which is linked to later antisocial behavior in offspring (29,30).…”

Section: Introductionmentioning

confidence: 99%

Perception of Caregiving During Childhood is Related to Later Executive Functions and Antisocial Behavior in At-Risk Boys

et al. 2020

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Executive functions are considered essential for effective navigation in the social world. Parental responsiveness is a critical ingredient for normative social development and, as such, may be connected with the development of executive functions. Disruption of this development may, in turn, lead to maladaptive and antisocial behaviors. The purpose of this study was to evaluate the nature of the connections among perceived patterns of caregiving experienced in childhood, executive functions, and antisocial behaviors in atrisk adolescents. Seventy-one adolescent boys were recruited from two high-schools for adolescents who were not deemed suitable for regular schooling due to behavioral and emotional issues. Executive functions were tested using a computer-administered neuropsychological battery (CANTAB), and maternal parenting experiences and antisocial behaviors were assessed using retrospective and current questionnaires. Structural equation modeling (SEM) approach was employed to examine whether executive functions mediated the relationship between children's perceived patterns of maternal care and subsequent development of antisocial behaviors. Although maternal care had a significant direct effect on executive function (standardized coefficient = .49, p = .03) and antisocial behavior (standardized coefficient = .53, p = .05), SEM demonstrated no mediating relationships among these variables. Instead, maternal care predicted unique variance in both executive functions (standardized coefficient = .61, p = .02) and antisocial behavior (standardized coefficient = .51, p = .05). This study suggests a link between the experience of childhood caregiving and adolescent executive functions and delinquency and highlights the importance of early parenting interventions to aid executive function development. Such early interventions could potentially enhance longterm pro-social behavior.

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“…Post-Traumatic Stress Disorder in Adolescence Increases the Likelihood of Developing ASPD (Wojciechowski, 2019). ASPD is a serious personality disorder with associations to homicide and violence, but its etiology is not precisely known (DeLisi et al, 2019).…”

Section: Literature Reviewmentioning

confidence: 99%

Intellectual Quotient and Social Cognition in Young Offenders: A Relational Analysis

Quintero-López¹,

Gil-Vera²,

Velez-Vásquez³

et al. 2020

MAS

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Antisocial personality disorder (ASPD) showed a broad executive function, as well as visual short-term, working memory (WM), and attention deficits. The inhibitory control and WM deficits may distinguish ASPD from other personality disorders. People with ASPD structure have deficiencies in the maturation of the prefrontal cortex which is evident in various neurocognitive problems, mainly in WM and social cognition (SC). In Colombia there is a high incidence of ASPD in young offenders, which makes the process of rehabilitation and resocialization more difficult. The aim of this paper was to develop a structural equation model (SEM) to identify the relationship between SC and intellectual quotient (IQ) in offenders with ASPD and make a comparative analysis by gender. A representative sample of 120 offenders was used (60 men and 60 women) of a Specialized Attention Center (SAC) in Medellin, Colombia. This paper concludes that there is a higher correlation between SC and IQ in women offenders with ASPD (σxy = 0.62) than in male offenders with ASPD (σxy = 0.54). Epidemiologists suggest that women have a high prevalence of depressive and anxiety disorders, which can be explained by internalized behavioral management. In general, men show a higher prevalence of disorders associated with impulse control through externalizing behavioral management. This shows that ASPD has been studied more in men and that ASPD profiles in women are lacking due to its low prevalence. Based on the results of the model developed, a neurocognitive profile of men and women with ASPD is presented.

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The etiology of antisocial personality disorder: The differential roles of adverse childhood experiences and childhood psychopathology

Cited by 66 publications

References 67 publications

Antisocial Personality Disorder Among Patients in Treatment for Alcohol Use Disorder (AUD): Characteristics and Predictors of Early Relapse or Drop-Out

Antisocial Personality Disorder Among Patients in Treatment for Alcohol Use Disorder (AUD): Characteristics and Predictors of Early Relapse or Drop-Out

Perception of Caregiving During Childhood is Related to Later Executive Functions and Antisocial Behavior in At-Risk Boys

Intellectual Quotient and Social Cognition in Young Offenders: A Relational Analysis

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