The etiology and antimicrobial susceptibility patterns of urinary tract infections at a private Nigerian teaching hospital in South West Nigeria

Elikwu, Charles John; Shobowale, Emmanuel Olushola; Oluyemi, O.Y.; Afolabi, DO; Aderinto, D.A.; Onyedibe, Kenneth I.; Solarin, Adaobi

doi:10.4314/ajcem.v18i1.3

Cited by 6 publications

(3 citation statements)

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“…which was the most common uropathogen of the Grampositive organisms, followed equally in proportion by species of Klebsiella, Proteus and Escherichia of the Gram-negative bacilli. The prevalence of Gram-negative bacilli constituted 69.2 % of the total isolated bacterial cause of UTI whereas the rate of only Gram-positive cocci constituted (30.8 %) in consistence with findings from previous studies [13,14].…”

Section: Age Distribution Pattern Of Patients Associated With Nutisupporting

confidence: 88%

Incidence of Nosocomial Urinary Tract Infections and Antibiotic Susceptibility Pattern of Uropathogenic Bacterial Isolates of Patients from Selected Hospitals in Nsukka, Nigeria

Aleke

Ugwu

Akoma

et al. 2021

IJPR

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Urinary Tract Infection (UTI) is one of the significant healthcare and hygienic-based diseases ravaging millions of people, especially in third world countries with poor hospital settings. This cross-sectional and laboratory investigation was done to determine the incidence of nosocomial urinary tract infections (NUTIs) and antibiotic susceptibility pattern of the uropathogenic bacterial isolates from hospital patients in Nsukka, Southeastern Nigeria. Urine specimens of fifty patients were collected and analyzed between May and June 2018. Kirby-Bauer disk diffusion method was used for detection of antibiotic susceptibility pattern for all isolates. Bacteriuria was observed in urine specimens of 31 (62%) out of the 50 participants, with the specimens of 13 yielding significant growth at 42% rate of nosocomial urinary tract infections (NUTIs). The most predominant bacterial isolate of urinary tract infection was Staphylococcus spp. (31%); followed by Escherichia, Klebsiella and Proteus with (23%) each. Isolates were mostly susceptible to Ciprofloxacin (87.1%), while other isolates were mainly resistant to Zinnacef (937%). Pertinent recommendations were made with respect to treatment, multidrug resistance mitigation and aseptic and optimal health services delivery practices.

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Section: Age Distribution Pattern Of Patients Associated With Nutisupporting

confidence: 88%

Incidence of Nosocomial Urinary Tract Infections and Antibiotic Susceptibility Pattern of Uropathogenic Bacterial Isolates of Patients from Selected Hospitals in Nsukka, Nigeria

Aleke

Ugwu

Akoma

et al. 2021

IJPR

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“…Denmark has similar prevalence rate and considered a low‐prevalence country (Pedersen, ; Storberg, ). Furthermore, almost 30% of Escherichia coli in the study were found to be resistant to cefpodoxime, a drug often used to screen for the presence of ESBL (Elikwu et al, ). Therefore, the rate of ESBL might be much higher than previously reported.…”

Section: Commentarymentioning

confidence: 99%

“…In studies from Africa, ESBL‐E has logically been found to vary between countries, but found to be common (Storberg, ). A recent publication by Elikwu et al, () on etiology and antimicrobial susceptibility patterns from urinary tract infections in Nigeria described that of all bacteria isolated from urine samples only 4% were caused by ESBL. Denmark has similar prevalence rate and considered a low‐prevalence country (Pedersen, ; Storberg, ).…”

Section: Commentarymentioning

confidence: 99%

ESBL‐production in Escherichia coli and Klebsiella pneumoniae isolates from Nigeria

et al. 2019

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The worldwide increase in infections caused by extended‐spectrum beta‐lactamase‐ (ESBL) and AmpC‐producing Enterobacteriaceae (ESBL‐E) is a concern. Surveillance is extensive in Europe, North America, and Asia. Yet, there is no summarizing surveillance in Africa. This study aimed to perform a preliminary investigation on the prevalence of ESBL‐E in the northeastern part of Nigeria. However, of the 60 samples collected, we were able to culture 15 Escherichia coli and 7 Klebsiella spp. only. In the collection of clinical hospital samples, we found eight of 15 E. coli isolates to be ESBL (53%) and two out of seven Klebsiella spp. to be ESBL/AmpC (29%). Due to the limitations of this study, our findings cannot take a broad view on the prevalence of ESBL‐E, in Nigeria and other parts of Africa. Yet, to know which genes encode ESBL in Nigeria, and to know exact prevalence of every ESBL gene would be of importance.

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Review and analysis of the overlapping threats of carbapenem and polymyxin resistant E. coli and Klebsiella in Africa

Venne

Hartley

Malchione

et al. 2023

Antimicrob Resist Infect Control

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Background Carbapenem-resistant Enterobacterales are among the most serious antimicrobial resistance (AMR) threats. Emerging resistance to polymyxins raises the specter of untreatable infections. These resistant organisms have spread globally but, as indicated in WHO reports, the surveillance needed to identify and track them is insufficient, particularly in less resourced countries. This study employs comprehensive search strategies with data extraction, meta-analysis and mapping to help address gaps in the understanding of the risks of carbapenem and polymyxin resistance in the nations of Africa. Methods Three comprehensive Boolean searches were constructed and utilized to query scientific and medical databases as well as grey literature sources through the end of 2019. Search results were screened to exclude irrelevant results and remaining studies were examined for relevant information regarding carbapenem and/or polymyxin(s) susceptibility and/or resistance amongst E. coli and Klebsiella isolates from humans. Such data and study characteristics were extracted and coded, and the resulting data was analyzed and geographically mapped. Results Our analysis yielded 1341 reports documenting carbapenem resistance in 40 of 54 nations. Resistance among E. coli was estimated as high (> 5%) in 3, moderate (1–5%) in 8 and low (< 1%) in 14 nations with at least 100 representative isolates from 2010 to 2019, while present in 9 others with insufficient isolates to support estimates. Carbapenem resistance was generally higher among Klebsiella: high in 10 nations, moderate in 6, low in 6, and present in 11 with insufficient isolates for estimates. While much less information was available concerning polymyxins, we found 341 reports from 33 of 54 nations, documenting resistance in 23. Resistance among E. coli was high in 2 nations, moderate in 1 and low in 6, while present in 10 with insufficient isolates for estimates. Among Klebsiella, resistance was low in 8 nations and present in 8 with insufficient isolates for estimates. The most widespread associated genotypes were, for carbapenems, blaOXA-48,blaNDM-1 and blaOXA-181 and, for polymyxins, mcr-1, mgrB, and phoPQ/pmrAB. Overlapping carbapenem and polymyxin resistance was documented in 23 nations. Conclusions While numerous data gaps remain, these data show that significant carbapenem resistance is widespread in Africa and polymyxin resistance is also widely distributed, indicating the need to support robust AMR surveillance, antimicrobial stewardship and infection control in a manner that also addresses broader animal and environmental health dimensions.

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The etiology and antimicrobial susceptibility patterns of urinary tract infections at a private Nigerian teaching hospital in South West Nigeria

Cited by 6 publications

References 0 publications

Incidence of Nosocomial Urinary Tract Infections and Antibiotic Susceptibility Pattern of Uropathogenic Bacterial Isolates of Patients from Selected Hospitals in Nsukka, Nigeria

Incidence of Nosocomial Urinary Tract Infections and Antibiotic Susceptibility Pattern of Uropathogenic Bacterial Isolates of Patients from Selected Hospitals in Nsukka, Nigeria

ESBL‐production in Escherichia coli and Klebsiella pneumoniae isolates from Nigeria

Review and analysis of the overlapping threats of carbapenem and polymyxin resistant E. coli and Klebsiella in Africa

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